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| | Tagg_0779 | COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: mca:MCA2827 phosphoribosyl transferase domain-containing protein; PFAM: phosphoribosyltransferase; SPTR: B8D3X3 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (204 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (274 aa) |
| | Tagg_0765 | Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: sfu:Sfum_2126 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: B8D615 Probable bis(5'-adenosyl)-triphosphatase, HIT family; PFAM: HIT domain. (173 aa) |
| | Tagg_0735 | PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611; KEGG: hiq:CGSHiGG_05785 ribokinase; PFAM: PfkB domain protein; SPTR: A3DLR5 PfkB domain protein; PFAM: pfkB family carbohydrate kinase. (315 aa) |
| | Tagg_0734 | COGs: COG2820 Uridine phosphorylase; InterPro IPR000845:IPR010058; KEGG: ara:Arad_9873 uridine phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: B8D4Y3 Uridine phosphorylase; TIGRFAM: uridine phosphorylase; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD); uridine phosphorylase. (291 aa) |
| | Tagg_0730 | COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638; KEGG: nis:NIS_1072 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: B8D4Y7 Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: putative nicotinate phosphoribosyltransferase. (389 aa) |
| | Tagg_0724 | COGs: COG0301 Thiamine biosynthesis ATP pyrophosphatase; InterPro IPR004114:IPR018317:IPR003720; KEGG: pmr:PMI0097 thiamine biosynthesis protein ThiI; PFAM: thiamine biosynthesis protein; THUMP domain protein; Queuosine synthesis-like; SPTR: A3DLP8 Thiamine biosynthesis protein; PFAM: Thiamine biosynthesis protein (ThiI); THUMP domain; TIGRFAM: thiazole biosynthesis/tRNA modification protein ThiI. (381 aa) |
| | nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (503 aa) |
| | Tagg_0379 | AMP phosphorylase; COGs: COG0213 Thymidine phosphorylase; InterProIPR013102:IPR000312:IPR017459:IPR017872:IPR 017713:IPR013466; KEGG: tau:Tola_2482 thymidine phosphorylase; PFAM: Pyrimidine nucleoside phosphorylase domain; glycosyl transferase family 3; Glycosyl transferase, family 3-like; PRIAM: Thymidine phosphorylase; SPTR: B8D2U0 AMP phosphorylase; TIGRFAM: AMP phosphorylase; thymidine phosphorylase; PFAM: Glycosyl transferase family, a/b domain; Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: AMP phosphorylase; pu [...] (507 aa) |
| | Tagg_0711 | MoaD family protein; COGs: COG1977 Molybdopterin converting factor small subunit; InterPro IPR003749:IPR010038; PFAM: thiamineS protein; SPTR: B8D538 Molybdopterin converting factor, small subunit; TIGRFAM: MoaD family protein; PFAM: ThiS family; TIGRFAM: MoaD family protein, archaeal. (89 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (223 aa) |
| | Tagg_0706 | COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR002587:IPR013021; KEGG: smd:Smed_3883 myo-inositol-1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; SPTR: B8D554 Myo-inositol-1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase. (381 aa) |
| | Tagg_0694 | Hypothetical protein; SPTR: B8D3N3 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (267 aa) |
| | Tagg_0673 | COGs: COG0120 Ribose 5-phosphate isomerase; InterPro IPR004788; KEGG: rpiA; ribose-5-phosphate isomerase; K01807 ribose 5-phosphate isomerase A; PFAM: Ribose 5-phosphate isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: B8D3V9 Ribose 5-phosphate isomerase; TIGRFAM: ribose 5-phosphate isomerase; PFAM: Ribose 5-phosphate isomerase A (phosphoriboisomerase A); TIGRFAM: ribose 5-phosphate isomerase. (236 aa) |
| | Tagg_0669 | Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; InterPro IPR006674; KEGG: AGAP012582-PA; K07023 putative hydrolases of HD superfamily; PFAM: metal-dependent phosphohydrolase HD sub domain; SPTR: B8D3W1 Metal dependent phosphohydrolase; PFAM: HD domain. (183 aa) |
| | Tagg_0658 | COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085:IPR003382:IPR005252; KEGG: gem:GM21_2546 phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein; SPTR: B8D3H7 Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopanto [...] (406 aa) |
| | Tagg_0656 | Pantothenate synthetase; COGs: COG1701 conserved hypothetical protein; InterPro IPR002855; PFAM: Protein of unknown function DUF137; SPTR: B8D3I1 Putative uncharacterized protein; PFAM: Protein of unknown function DUF137. (260 aa) |
| | Tagg_0655 | COGs: COG1829 kinase (sugar kinase superfamily); SPTR: B8D3I2 Kinase (Sugar kinase superfamily)-like protein. (279 aa) |
| | Tagg_0008 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (199 aa) |
| | Tagg_0012 | thiamineS protein; InterPro IPR003749; PFAM: thiamineS protein; SPTR: B8D6I3 Molybdopterin converting factor, small subunit; PFAM: ThiS family. (95 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (332 aa) |
| | Tagg_0024 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa) |
| | Tagg_0063 | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; COGs: COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; InterPro IPR000537; KEGG: ATHST; ATHST; prenyltransferase; K12501 homogentisate solanesyltransferase; PFAM: UbiA prenyltransferase; SPTR: Q46510 ORF 1; PFAM: UbiA prenyltransferase family. (288 aa) |
| | Tagg_0077 | Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; InterPro IPR001279; KEGG: sat:SYN_01177 metallo-beta-lactamase superfamily protein; PFAM: beta-lactamase domain protein; SPTR: A3DNQ3 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (234 aa) |
| | atpB | H(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (470 aa) |
| | atpA | H(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (584 aa) |
| | Tagg_0080 | Hypothetical protein; SPTR: B8D5E1 Putative uncharacterized protein. (115 aa) |
| | atpE | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | Tagg_0087 | COGs: COG1394 H+-ATPase subunit D; InterPro IPR002699:IPR018483; KEGG: similar to vacuolar proton pump delta polypeptide; K02149 V-type H+-transporting ATPase subunit D; PFAM: H+transporting two-sector ATPase D subunit; SPTR: A3DNR4 V-type ATPase, D subunit; TIGRFAM: V-type ATPase, D subunit; PFAM: ATP synthase subunit D; TIGRFAM: H(+)-transporting ATP synthase, vacuolar type, subunit D. (206 aa) |
| | Tagg_0090 | NUDIX hydrolase; InterPro IPR000086:IPR020084:IPR004385; KEGG: pca:Pcar_0414 NTP pyrophosphohydrolase; PFAM: NUDIX hydrolase; SPTR: B8D5D2 ADP-ribose pyrophosphatase; PFAM: NUDIX domain; TIGRFAM: nudix hydrolase, YffH family. (180 aa) |
| | Tagg_0092 | CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR000462; KEGG: ank:AnaeK_2943 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: B8D5D0 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (193 aa) |
| | Tagg_0097 | Adenylyl cyclase CyaB; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008172:IPR008173; KEGG: dvl:Dvul_1534 adenylate cyclase; PFAM: adenylate cyclase; SPTR: B8D5C7 Putative adenylyl cyclase CyaB; TIGRFAM: adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. (185 aa) |
| | Tagg_0106 | Protein of unknown function DUF120; COGs: COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon; InterPro IPR002834; KEGG: eba:ebA3131 hypothetical protein; PFAM: protein of unknown function DUF120; SPTR: B8D5C1 Riboflavin kinase; PFAM: Domain of unknown function DUF120. (143 aa) |
| | Tagg_0121 | thiamineS protein; InterPro IPR003749; PFAM: thiamineS protein; PFAM: ThiS family. (98 aa) |
| | Tagg_0139 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR002375:IPR006034:IPR005946; KEGG: wsu:WS1635 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: A3DNX0 Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (304 aa) |
| | Tagg_0153 | Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (177 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (437 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa) |
| | Tagg_0225 | COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752; KEGG: gur:Gura_2134 indolepyruvate oxidoreductase subunit beta; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: B8D3K9 Indolepyruvate oxidoreductase subunit iorB; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: indolepyruvate ferredoxin oxidoreductase, beta subunit. (200 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173:IPR000846:IPR006436; KEGG: ajs:Ajs_2165 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); SPTR: B8D2W6 Glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceral [...] (343 aa) |
| | pgk | COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576:IPR015911; KEGG: phosphoglycerate kinase; K00927 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: B8D2W5 Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa) |
| | Tagg_0303 | COGs: COG0167 Dihydroorotate dehydrogenase; InterPro IPR001450:IPR012135:IPR017900:IPR005720; KEGG: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8D2W4 Dihydroorotate dehydrogenase family protein; TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: Dihydroorotate dehydrogenase; 4Fe-4S binding domain; TIGRFAM: dihydroorotate dehydrogenase (subfamily 1) family protein. (403 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (307 aa) |
| | Tagg_0325 | Protein of unknown function DUF84; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (178 aa) |
| | Tagg_0329 | COGs: COG0035 Uracil phosphoribosyltransferase; KEGG: cti:RALTA_B1432 uracil phosphoribosyltransferase; PRIAM: Uracil phosphoribosyltransferase; SPTR: A3DKX7 Uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase. (232 aa) |
| | Tagg_0332 | hydroxymethylglutaryl-CoA reductase, degradative; COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR002202:IPR004553; KEGG: bpt:Bpet3342 3-hydroxy-3-methylglutaryl-coenzyme A reductase; PRIAM: Hydroxymethylglutaryl-CoA reductase; SPTR: A3DKY1 Hydroxymethylglutaryl-CoA reductase, degradative; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (426 aa) |
| | Tagg_0359 | Cytidyltransferase-related domain protein; COGs: COG1056 Nicotinamide mononucleotide adenylyltransferase; InterPro IPR004820:IPR004821; KEGG: dac:Daci_5608 cytidyltransferase-like protein; PFAM: cytidylyltransferase; PRIAM: Nicotinamide-nucleotide adenylyltransferase; SPTR: B8D4Q4 Cytidyltransferase-related domain protein; TIGRFAM: cytidyltransferase-related domain protein; PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. (182 aa) |
| | Tagg_0364 | Metal dependent phosphohydrolase; COGs: COG1078 HD superfamily phosphohydrolase; InterPro IPR006674:IPR003607; KEGG: aha:AHA_2754 HD domain-containing protein; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: A3DPL0 Metal-dependent phosphohydrolase, HD region; PFAM: HD domain. (523 aa) |
| | Tagg_0378 | 2,3-di-O-geranylgeranylglyceryl phosphate reductase; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR003042:IPR013027:IPR006076:IPR011777; KEGG: dal:Dalk_0352 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: B8D2U1 Geranylgeranyl reductase; TIGRFAM: geranylgeranyl reductase; PFAM: Thi4 family; TIGRFAM: geranylgeranyl reductase family. (456 aa) |
| | Tagg_1373 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (161 aa) |
| | Tagg_1368 | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa) |
| | Tagg_1265 | COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766:IPR011896; KEGG: dat:HRM2_41100 PorB3; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: A2BLG9 2-oxoglutarate synthase subunit korB; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family. (317 aa) |
| | Tagg_1264 | 2-oxoglutarate synthase; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: dvm:DvMF_0184 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PRIAM: 2-oxoglutarate synthase; SPTR: Q9YA13 2-oxoacid:ferredoxin oxidoreductase alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase. (636 aa) |
| | Tagg_1254 | Cytidyltransferase-related domain protein; COGs: COG1056 Nicotinamide mononucleotide adenylyltransferase; InterPro IPR004820:IPR004821; KEGG: aav:Aave_0974 cytidyltransferase-like protein; PFAM: cytidylyltransferase; PRIAM: Nicotinamide-nucleotide adenylyltransferase; SPTR: A3DN25 Nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. (173 aa) |
| | egsA | 3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (348 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa) |
| | Tagg_1237 | COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: nis:NIS_1773 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A3DMY9 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (467 aa) |
| | Tagg_1220 | Phosphoribosyltransferase; COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; InterPro IPR000836; KEGG: maq:Maqu_2814 adenine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: B8D622 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (269 aa) |
| | Tagg_1198 | COGs: COG0035 Uracil phosphoribosyltransferase; KEGG: rfr:Rfer_2073 uracil phosphoribosyltransferase; PRIAM: Uracil phosphoribosyltransferase; SPTR: B8D4X5 Uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase. (221 aa) |
| | Tagg_1183 | ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR002504; KEGG: cja:CJA_2375 NAD(+)/NADH kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: B8D5H1 ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase. (377 aa) |
| | Tagg_1165 | COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: sat:SYN_03353 xanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: B8D3B6 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (184 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | Tagg_1160 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (168 aa) |
| | tmk | COGs: COG0125 Thymidylate kinase; InterPro IPR000062:IPR018095:IPR018094; KEGG: xfn:XfasM23_1654 dTMP kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: B8D357 Thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (203 aa) |
| | Tagg_1141 | Inositol monophosphatase; COGs: COG0483 fructose-1 6-bisphosphatase of inositol monophosphatase family; InterPro IPR000760; KEGG: pen:PSEEN1005 inositol-1-monophosphatase (IMPase) (inositol-1-phosphatase) (I-1-Pase); PFAM: inositol monophosphatase; SPTR: B8D559 Inositol-1-monophosphatase; PFAM: Inositol monophosphatase family. (275 aa) |
| | Tagg_1016 | COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836:IPR002375; KEGG: sat:SYN_03353 xanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: B8D5J0 Predicted phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (227 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (272 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (315 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (177 aa) |
| | rbcL | Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (445 aa) |
| | cmk | COGs: COG1102 Cytidylate kinase; InterPro IPR011892; KEGG: similar to UMP-CMP kinase (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase); PRIAM: Cytidylate kinase; SPTR: B8D5U4 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Adenylate kinase; TIGRFAM: cytidylate kinase, putative. (180 aa) |
| | Tagg_0829 | Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR011894; KEGG: sfu:Sfum_0543 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; PRIAM: Pyruvate synthase; SPTR: B8D5Y0 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxo [...] (192 aa) |
| | Tagg_0828 | COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR001450:IPR017900:IPR011898; KEGG: sat:SYN_00694 pyruvate synthase delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8D5Y1 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (93 aa) |
| | Tagg_0824 | MazG nucleotide pyrophosphohydrolase; InterPro IPR004518; KEGG: ftm:FTM_0547 hypothetical protein; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: B8D5Y5 MazG nucleotide pyrophosphohydrolase; PFAM: MazG nucleotide pyrophosphohydrolase domain. (94 aa) |
| | Tagg_0823 | Geranylgeranylglyceryl diphosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (246 aa) |
| | Tagg_0654 | COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR019304:IPR006124:IPR001917:IPR004456; KEGG: gme:Gmet_1428 cofactor-independent phosphoglycerate mutase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: B8D3I3 Phosphonopyruvate decarboxylase-related protein; TIGRFAM: phosphonopyruvate decarboxylase-related protein; PFAM: Metalloenzyme superfamily; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form. (434 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (268 aa) |
| | Tagg_0650 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | Tagg_0616 | Molybdopterin biosynthesis MoaE protein; COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: abc:ACICU_02123 molybdopterin converting factor, large subunit; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: B8D2Z0 MoaD family protein; PFAM: MoaE protein. (161 aa) |
| | Tagg_0615 | thiamineS protein; InterPro IPR003749; KEGG: dol:Dole_2503 thiamineS protein; PFAM: thiamineS protein; SPTR: B8D2Z1 MoaD family protein; PFAM: ThiS family. (76 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (148 aa) |
| | Tagg_0613 | Radical SAM domain protein; COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterPro IPR010505:IPR007197:IPR006638; KEGG: abu:Abu_0369 molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM domain protein; molybdenum cofactor synthesis domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: B8D2Z3 Probable molybdenum cofactor biosynthesis protein A; PFAM: Molybdenum Cofactor Synthesis C; Radical SAM superfamily; TIGRFAM: probable molybdenum cofactor biosynthesis protein A, archaeal. (306 aa) |
| | Tagg_0609 | Molybdopterin binding domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR001453; KEGG: dat:HRM2_07090 putative molybdopterin biosynthesis protein MoeA; PFAM: molybdopterin binding domain; SPTR: B8D2Z7 Molybdopterin binding domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (331 aa) |
| | Tagg_0605 | COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453:IPR008284; KEGG: mxa:MXAN_2759 molybdenum cofactor biosynthesis protein B; PFAM: molybdopterin binding domain; SPTR: A3DLA6 Molybdenum cofactor synthesis domain; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (160 aa) |
| | mptD | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). (128 aa) |
| | mptE | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (246 aa) |
| | Tagg_0592 | Protein of unknown function DUF198; COGs: COG1469 conserved hypothetical protein; InterPro IPR003801; KEGG: rpi:Rpic_2425 putative GTP cyclohydrolase; PFAM: protein of unknown function DUF198; SPTR: B8D3S2 Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1469. (285 aa) |
| | Tagg_0571 | Hypothetical protein. (224 aa) |
| | Tagg_0556 | Metal dependent phosphohydrolase; COGs: COG1078 HD superfamily phosphohydrolase; InterPro IPR003607; KEGG: aha:AHA_2754 HD domain-containing protein; SMART: metal-dependent phosphohydrolase HD region; SPTR: B8D4A0 Metal dependent phosphohydrolase; PFAM: HD domain. (531 aa) |
| | Tagg_0554 | COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: dvm:DvMF_1751 fructose-bisphosphate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Fructose-bisphosphate aldolase; SPTR: B8D4B1 Fructose-bisphosphate aldolase; PFAM: DeoC/LacD family aldolase. (271 aa) |
| | Tagg_0553 | COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611:IPR002173; KEGG: gbm:Gbem_2483 PfkB domain protein; PFAM: PfkB domain protein; SPTR: B8D4B0 ATP-dependent 6-phosphofructokinase; PFAM: pfkB family carbohydrate kinase. (306 aa) |
| | Tagg_0539 | Amidohydrolase; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; InterPro IPR006680; KEGG: D-hydantoinase (EC:3.5.2.2); K01465 dihydroorotase; PFAM: amidohydrolase; SPTR: A3DKS9 Amidohydrolase; PFAM: Amidohydrolase family; TIGRFAM: dihydroorotase, multifunctional complex type. (446 aa) |
| | Tagg_0531 | Conserved hypothetical protein; COGs: COG2403 GTPase; KEGG: ppd:Ppro_0567 hypothetical protein; SPTR: B8D4C7 Putative uncharacterized protein. (443 aa) |
| | Tagg_0486 | ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600:IPR006025; KEGG: rlt:Rleg2_5489 ROK family protein; PFAM: ROK family protein; SPTR: B8D441 Glucokinase (ROK family protein); PFAM: ROK family. (322 aa) |
| | Tagg_0469 | Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR005111:IPR005110:IPR001453:IPR008284; KEGG: dps:DP2474 molybdenum cofactor biosynthesis protein (MoeA); PFAM: MoeA domain protein domain I and II; MoeA domain protein domain IV; molybdopterin binding domain; SPTR: B8D3Z7 Molybdenum cofactor synthesis domain protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain. (410 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (237 aa) |
| | Tagg_0393 | COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR018202; KEGG: afw:Anae109_1896 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: B8D428 2-oxoglutarate oxidoreductase gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase. (177 aa) |
| | Tagg_0392 | 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: sfu:Sfum_0016 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8D429 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (276 aa) |
| | Tagg_0389 | Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR011894; KEGG: sat:SYN_00157 pyruvate:ferredoxin oxidoreductase gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: B8D476 Pyruvate synthase subunit porC; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. (185 aa) |
| | Tagg_0388 | Pyruvate ferredoxin oxidoreductase, delta subunit; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR001450:IPR017900:IPR011898; KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8D475 Pyruvate synthase subunit porD; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (93 aa) |
| | Tagg_0384 | COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR003042; KEGG: nam:NAMH_1575 geranylgeranyl hydrogenase; SPTR: A3DPI3 Putative uncharacterized protein; PFAM: Lycopene cyclase protein. (368 aa) |
| | Tagg_0780 | COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR006220:IPR011702:IPR001317:IPR001674:IPR 000991:IPR004739; KEGG: mes:Meso_0495 GMP synthase; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: B8D3X4 GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit. (521 aa) |
