(29 nodes) Tricarboxylic acid cycle, and Pyruvate metabolism network (Trichinella nelsoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MDHG	Malate dehydrogenase, glyoxysomal. (52 aa)
	HPR-A	Glycerate dehydrogenase. (87 aa)
	T07_14715	PDZ domain-containing protein. (154 aa)
	T01C8.5	Aspartate aminotransferase. (403 aa)
	F42A8.1	Uncharacterized protein. (356 aa)
	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (450 aa)
	idha-1	Putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. (424 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (595 aa)
	dlst	annotation not available (534 aa)
	PEPCK	Phosphoenolpyruvate carboxykinase [GTP]. (740 aa)
	T07_15135	2-oxoglutarate dehydrogenase, mitochondrial. (1189 aa)
	got2	Aspartate aminotransferase. (422 aa)
	mev-1	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial. (185 aa)
	sdhd-1	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (185 aa)
	ACAC	Acetyl-CoA carboxylase. (2408 aa)
	sdhb-1	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (680 aa)
	MDH1	Malate dehydrogenase. (336 aa)
	ME1	Malic enzyme. (592 aa)
	ldh-1	L-lactate dehydrogenase. (415 aa)
	F42A8.1-2	Uncharacterized protein. (364 aa)
	idhb-1	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (376 aa)
	aco-2	Putative aconitate hydratase, mitochondrial. (2164 aa)
	sdha-1	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (863 aa)
	T07_330	RING-type domain-containing protein. (502 aa)
	pyc-1	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1171 aa)
	Me3	Malic enzyme; Belongs to the malic enzymes family. (1256 aa)
	ACLY	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1110 aa)
	Fh	Fumarate hydratase, mitochondrial. (508 aa)

Your Current Organism:

Trichinella nelsoni

NCBI taxonomy Id: 6336
Other names: T. nelsoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAC	ACLY	A0A0V0S712	A0A0V0SL38	Acetyl-CoA carboxylase.	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	0.936
ACAC	F42A8.1	A0A0V0S712	A0A0V0RMH2	Acetyl-CoA carboxylase.	Uncharacterized protein.	0.582
ACAC	F42A8.1-2	A0A0V0S712	A0A0V0SC76	Acetyl-CoA carboxylase.	Uncharacterized protein.	0.582
ACAC	HPR-A	A0A0V0S712	A0A0V0RB07	Acetyl-CoA carboxylase.	Glycerate dehydrogenase.	0.851
ACAC	MDH1	A0A0V0S712	A0A0V0SA49	Acetyl-CoA carboxylase.	Malate dehydrogenase.	0.729
ACAC	MDHG	A0A0V0S712	A0A0V0RAC2	Acetyl-CoA carboxylase.	Malate dehydrogenase, glyoxysomal.	0.729
ACAC	ME1	A0A0V0S712	A0A0V0SAK5	Acetyl-CoA carboxylase.	Malic enzyme.	0.827
ACAC	Me3	A0A0V0S712	A0A0V0SKY6	Acetyl-CoA carboxylase.	Malic enzyme; Belongs to the malic enzymes family.	0.827
ACAC	PEPCK	A0A0V0S712	A0A0V0RWQ1	Acetyl-CoA carboxylase.	Phosphoenolpyruvate carboxykinase [GTP].	0.843
ACAC	PKM	A0A0V0S712	A0A0V0RTV0	Acetyl-CoA carboxylase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.801
ACAC	SUCLA2	A0A0V0S712	A0A0V0RN87	Acetyl-CoA carboxylase.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.895
ACAC	T01C8.5	A0A0V0S712	A0A0V0RG81	Acetyl-CoA carboxylase.	Aspartate aminotransferase.	0.741
ACAC	T07_14715	A0A0V0S712	A0A0V0RG35	Acetyl-CoA carboxylase.	PDZ domain-containing protein.	0.918
ACAC	T07_330	A0A0V0S712	A0A0V0SGS9	Acetyl-CoA carboxylase.	RING-type domain-containing protein.	0.729
ACAC	dlst	A0A0V0S712	A0A0V0RUC1	Acetyl-CoA carboxylase.	annotation not available	0.556
ACAC	got2	A0A0V0S712	A0A0V0S074	Acetyl-CoA carboxylase.	Aspartate aminotransferase.	0.741
ACAC	ldh-1	A0A0V0S712	A0A0V0SBV7	Acetyl-CoA carboxylase.	L-lactate dehydrogenase.	0.729
ACAC	mev-1	A0A0V0S712	A0A0V0S385	Acetyl-CoA carboxylase.	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial.	0.829
ACAC	pyc-1	A0A0V0S712	A0A0V0SKC8	Acetyl-CoA carboxylase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.927
ACAC	sdha-1	A0A0V0S712	A0A0V0SEZ5	Acetyl-CoA carboxylase.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.850