STRINGSTRING
Fanci Fanci ERCC1 ERCC1 REV1 REV1 telo2 telo2 Brip1 Brip1 RPA2 RPA2 RAD51 RAD51 papd4-b papd4-b papd4-a papd4-a POLQ POLQ Top3b Top3b POLQ-2 POLQ-2 Brca2 Brca2 FANCM FANCM ATR-2 ATR-2 slx1 slx1 sas6 sas6 Brip1-2 Brip1-2 ran-4 ran-4 HELQ HELQ T4B_12429 T4B_12429 Top3a Top3a TOP3A TOP3A Top3alpha Top3alpha POLH POLH ERCC4 ERCC4 fan-1 fan-1 Rev3l Rev3l Brca1 Brca1 hes1-b hes1-b ABCF1 ABCF1 mus81-2 mus81-2 CDC45 CDC45 SPTLC1-2 SPTLC1-2 Faap24 Faap24 Mical2-2 Mical2-2 T4E_10094 T4E_10094 T4E_4003 T4E_4003 FANCD2 FANCD2 Mical2 Mical2 MLH1 MLH1 him-6 him-6 T4E_3040 T4E_3040 RAD51C RAD51C RPA1 RPA1 rmi1 rmi1 mus81 mus81 mus309 mus309 ATR ATR hes2 hes2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FanciFanconi anemia group I-like protein. (1349 aa)
ERCC1DNA excision repair protein ERCC-1. (315 aa)
REV1DNA repair protein REV1. (739 aa)
telo2Telomere length regulation protein TEL2-like protein. (845 aa)
Brip1Fanconi anemia group J-like protein. (847 aa)
RPA2Replication protein A 32 kDa subunit. (269 aa)
RAD51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (363 aa)
papd4-bPoly(A) RNA polymerase GLD2-B. (894 aa)
papd4-aPoly(A) RNA polymerase GLD2-A. (425 aa)
POLQDNA polymerase theta. (1704 aa)
Top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (860 aa)
POLQ-2DNA polymerase theta. (428 aa)
Brca2Breast cancer type 2 susceptibility-like protein. (1238 aa)
FANCMFanconi anemia group M protein. (1770 aa)
ATR-2Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1789 aa)
slx1Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (302 aa)
sas6Spindle assembly abnormal protein 6-like protein. (478 aa)
Brip1-2Fanconi anemia group J-like protein. (822 aa)
ran-4Putative nuclear transport factor 2. (134 aa)
HELQHelicase POLQ-like. (890 aa)
T4B_12429Uncharacterized protein. (230 aa)
Top3aDNA topoisomerase 3-alpha. (324 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (321 aa)
Top3alphaDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (232 aa)
POLHDNA polymerase eta. (651 aa)
ERCC4DNA repair endonuclease XPF. (755 aa)
fan-1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (730 aa)
Rev3lDNA polymerase. (1679 aa)
Brca1Breast cancer type 1 susceptibility-like protein. (318 aa)
hes1-bTranscription factor HES-1-B. (320 aa)
ABCF1WD repeat-containing protein 48. (1445 aa)
mus81-2Crossover junction endonuclease MUS81. (266 aa)
CDC45Cell division control protein 45-like protein. (558 aa)
SPTLC1-2Mismatch repair endonuclease PMS2. (878 aa)
Faap24Fanconi anemia-associated protein of 24 kDa. (209 aa)
Mical2-2Protein-methionine sulfoxide oxidase MICAL2. (1012 aa)
T4E_10094Regulator of telomere elongation helicase 1-like protein. (1022 aa)
T4E_4003Regulator of telomere elongation helicase 1-like protein. (1041 aa)
FANCD2Fanconi anemia group D2 protein. (1424 aa)
Mical2Protein-methionine sulfoxide oxidase MICAL2. (565 aa)
MLH1DNA mismatch repair protein Mlh1. (681 aa)
him-6Bloom syndrome-like protein. (264 aa)
T4E_3040Uncharacterized protein. (116 aa)
RAD51CDNA repair protein RAD51-like protein 3. (224 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (482 aa)
rmi1RecQ-mediated genome instability protein 1. (563 aa)
mus81Crossover junction endonuclease MUS81. (200 aa)
mus309Bloom syndrome-like protein. (345 aa)
ATRSerine/threonine-protein kinase ATR. (171 aa)
hes2Transcription factor HES-2. (121 aa)
Your Current Organism:
Trichinella pseudospiralis
NCBI taxonomy Id: 6337
Other names: T. pseudospiralis
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.