STRINGSTRING
SHF76147.1 SHF76147.1 SHF76206.1 SHF76206.1 SHF81930.1 SHF81930.1 SHF85834.1 SHF85834.1 asd asd ilvA ilvA ilvD ilvD ilvE ilvE ilvC ilvC SHG04195.1 SHG04195.1 SHG04222.1 SHG04222.1 metAS metAS dapD dapD SHG11443.1 SHG11443.1 metK metK SHG18630.1 SHG18630.1 SHG21152.1 SHG21152.1 SHG22042.1 SHG22042.1 cysS cysS asd-2 asd-2 dapB dapB SHG46384.1 SHG46384.1 SHG59687.1 SHG59687.1 SHG62761.1 SHG62761.1 leuA leuA leuB leuB leuC leuC leuD leuD SHG67676.1 SHG67676.1 thrB thrB SHG67741.1 SHG67741.1 SHG70583.1 SHG70583.1 SHG94862.1 SHG94862.1 SHG94901.1 SHG94901.1 SHG96557.1 SHG96557.1 SHH03259.1 SHH03259.1 SHH03691.1 SHH03691.1 SHH05596.1 SHH05596.1 SHH06446.1 SHH06446.1 serC serC dapA dapA SHH07927.1 SHH07927.1 SHH08480.1 SHH08480.1 SHH12818.1 SHH12818.1 SHH29758.1 SHH29758.1 SHH35664.1 SHH35664.1 SHH35692.1 SHH35692.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHF76147.1Aspartate/methionine/tyrosine aminotransferase. (396 aa)
SHF76206.1Cystathionine beta-lyase/cystathionine gamma-synthase. (392 aa)
SHF81930.1Serine O-acetyltransferase. (269 aa)
SHF85834.1Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. (359 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (373 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (616 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (310 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
SHG04195.15-methyltetrahydrofolate--homocysteine methyltransferase. (874 aa)
SHG04222.15-methyltetrahydrofolate--homocysteine methyltransferase. (351 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (312 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
SHG11443.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (382 aa)
SHG18630.1Aspartate kinase; Belongs to the aspartokinase family. (449 aa)
SHG21152.1Cysteine synthase A. (329 aa)
SHG22042.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (458 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
SHG46384.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (344 aa)
SHG59687.1Phosphoserine phosphatase. (338 aa)
SHG62761.1Serine O-acetyltransferase. (273 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (519 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuC3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuD3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (203 aa)
SHG67676.1Threonine synthase. (429 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (318 aa)
SHG67741.1Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
SHG70583.1Cystathionine beta-lyase/cystathionine gamma-synthase. (595 aa)
SHG94862.1Acetolactate synthase, large subunit. (572 aa)
SHG94901.1Acetolactate synthase, small subunit. (165 aa)
SHG96557.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (363 aa)
SHH03259.1L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
SHH03691.1Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (373 aa)
SHH05596.1Thiosulfate/3-mercaptopyruvate sulfurtransferase. (283 aa)
SHH06446.1Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (375 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
SHH07927.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (321 aa)
SHH08480.1O-acetylhomoserine (thiol)-lyase. (414 aa)
SHH12818.1Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (404 aa)
SHH29758.1Threonine dehydratase. (334 aa)
SHH35664.1Hypothetical protein. (378 aa)
SHH35692.1Ornithine cyclodeaminase. (315 aa)
Your Current Organism:
Marisediminitalea aggregata
NCBI taxonomy Id: 634436
Other names: Aestuariibacter aggregatus, Aestuariibacter aggregatus Wang et al. 2010, Alteromonas sp. WH169, CGMCC 1.8995, LMG 25283, LMG:25283, M. aggregata, Marisediminitalea aggregata (Wang et al. 2010) Zhang et al., strain WH169
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