STRINGSTRING
pepQ pepQ SHF71895.1 SHF71895.1 SHF75681.1 SHF75681.1 SHF76206.1 SHF76206.1 SHF84652.1 SHF84652.1 SHF85263.1 SHF85263.1 asd asd ilvA ilvA SHF91395.1 SHF91395.1 gcvP gcvP gcvH gcvH gcvT gcvT SHG11167.1 SHG11167.1 SHG11259.1 SHG11259.1 SHG11443.1 SHG11443.1 SHG11648.1 SHG11648.1 SHG18630.1 SHG18630.1 srkA srkA SHG38398.1 SHG38398.1 asd-2 asd-2 SHG41975.1 SHG41975.1 trpB trpB trpA trpA SHG48045.1 SHG48045.1 SHG50319.1 SHG50319.1 SHG58518.1 SHG58518.1 glyA glyA SHG59687.1 SHG59687.1 SHG67676.1 SHG67676.1 thrB thrB SHG67741.1 SHG67741.1 SHG71606.1 SHG71606.1 SHG74583.1 SHG74583.1 kbl kbl tdh tdh SHG86090.1 SHG86090.1 pqqC pqqC gpmI gpmI SHH03259.1 SHH03259.1 SHH04793.1 SHH04793.1 serC serC SHH07116.1 SHH07116.1 SHH07555.1 SHH07555.1 SHH10590.1 SHH10590.1 SHH17959.1 SHH17959.1 SHH20262.1 SHH20262.1 SHH28399.1 SHH28399.1 SHH29758.1 SHH29758.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pepQXaa-Pro dipeptidase; Splits dipeptides with a prolyl residue in the C-terminal position. (439 aa)
SHF71895.1Monoamine oxidase. (522 aa)
SHF75681.1Phytanoyl-CoA dioxygenase (PhyH). (263 aa)
SHF76206.1Cystathionine beta-lyase/cystathionine gamma-synthase. (392 aa)
SHF84652.1Glyoxylate/hydroxypyruvate reductase A. (310 aa)
SHF85263.1Glycine/D-amino acid oxidase. (440 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (373 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
SHF91395.1Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (309 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (965 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
SHG11167.1Xaa-Pro dipeptidase. (428 aa)
SHG11259.1Xaa-Pro aminopeptidase; Belongs to the peptidase M24B family. (436 aa)
SHG11443.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
SHG11648.1Dihydrolipoamide dehydrogenase. (472 aa)
SHG18630.1Aspartate kinase; Belongs to the aspartokinase family. (449 aa)
srkASer/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (325 aa)
SHG38398.1Hypothetical protein. (376 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
SHG41975.1Choline dehydrogenase; Belongs to the GMC oxidoreductase family. (537 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
SHG48045.1Succinylglutamate desuccinylase / Aspartoacylase family protein. (304 aa)
SHG50319.1D-serine deaminase, pyridoxal phosphate-dependent. (377 aa)
SHG58518.1CDP-diacylglycerol---serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (280 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
SHG59687.1Phosphoserine phosphatase. (338 aa)
SHG67676.1Threonine synthase. (429 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (318 aa)
SHG67741.1Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
SHG71606.1Glycine/D-amino acid oxidase. (397 aa)
SHG74583.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (231 aa)
kblGlycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
tdhThreonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
SHG86090.1Phenylpropionate dioxygenase, large terminal subunit. (396 aa)
pqqCPyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (251 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
SHH03259.1L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
SHH04793.1Predicted arabinose efflux permease, MFS family. (400 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
SHH07116.1Arsenate reductase. (117 aa)
SHH07555.1D-glycerate 3-kinase. (295 aa)
SHH10590.1Ecdysteroid kinase. (328 aa)
SHH17959.1Phytanoyl-CoA dioxygenase (PhyH). (226 aa)
SHH20262.1Transcriptional regulator, Spx/MgsR family; Belongs to the ArsC family. (115 aa)
SHH28399.1Hypothetical protein. (344 aa)
SHH29758.1Threonine dehydratase. (334 aa)
Your Current Organism:
Marisediminitalea aggregata
NCBI taxonomy Id: 634436
Other names: Aestuariibacter aggregatus, Aestuariibacter aggregatus Wang et al. 2010, Alteromonas sp. WH169, CGMCC 1.8995, LMG 25283, LMG:25283, M. aggregata, Marisediminitalea aggregata (Wang et al. 2010) Zhang et al., strain WH169
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