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mru_0068 mru_0068 rpl21e rpl21e rpl44e rpl44e eif2a eif2a mru_0306 mru_0306 rps19e rps19e rpl31e rpl31e rplX rplX rps3ae rps3ae rpl11 rpl11 rpl1p rpl1p rplPO rplPO rpl12 rpl12 mru_0507 mru_0507 ef1b ef1b eif2b eif2b prf1 prf1 rpl3p rpl3p rpl4p rpl4p rpl23 rpl23 rpl2p rpl2p rps19p rps19p rpl22 rpl22 rps3p rps3p rpl29 rpl29 mru_0859 mru_0859 rps17 rps17 rpl14 rpl14 rpl24 rpl24 rps4e rps4e rpl5p rpl5p rps14 rps14 rps8p rps8p rpl6p rpl6p mru_0869 mru_0869 rpl19e rpl19e rpl18 rpl18 rps5p rps5p rpl30 rpl30 rpl15 rpl15 rpl34e rpl34e mru_0880 mru_0880 rps13 rps13 rps4p rps4p rps11 rps11 rpl18e rpl18e rpl13 rpl13 rps9p rps9p rps2p rps2p gltX gltX proS proS rpl40e rpl40e rpl37e rpl37e rpl15e rpl15e mru_1474 mru_1474 rps24e rps24e eif2g eif2g rps6e rps6e rpl24e rpl24e rps28e rps28e rpl7ae rpl7ae rps17e rps17e rps10 rps10 tuf tuf fusA-2 fusA-2 rps7p rps7p rps12 rps12 rpl30e rpl30e eif1a eif1a rpl10e rpl10e map map rps15 rps15
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mru_0068Non-ribosomal peptide synthetase. (2687 aa)
rpl21eRibosomal protein L21e Rpl21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
eif2aTranslation initiation factor aIF-2 alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (260 aa)
mru_0306Hypothetical protein. (231 aa)
rps19eRibosomal protein S19e Rps19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
rpl31eRibosomal protein L31e Rpl31e; Belongs to the ribosomal protein L31e family. (86 aa)
rplXRibosomal protein LX RplX. (74 aa)
rps3aeRibosomal protein S3Ae Rps3ae; Belongs to the eukaryotic ribosomal protein eS1 family. (192 aa)
rpl11Ribosomal protein L11P Rpl11p; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa)
rpl1pRibosomal protein L1P Rpl1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rplPOAcidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (335 aa)
rpl12Ribosomal protein L12P Rpl12p; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (103 aa)
mru_0507ATPase RIL. (591 aa)
ef1bTranslation elongation factor aEF-1 beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (89 aa)
eif2bTranslation initiation factor aIF-2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (135 aa)
prf1Peptide chain release factor aRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (414 aa)
rpl3pRibosomal protein L3P Rpl3p; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa)
rpl4pRibosomal protein L4p Rpl4p; Forms part of the polypeptide exit tunnel. (254 aa)
rpl23Ribosomal protein L23P Rpl23p; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl2pRibosomal protein L2P Rpl2p; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (241 aa)
rps19pRibosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rpl22Ribosomal protein L22P Rpl22p; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (155 aa)
rps3pRibosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (251 aa)
rpl29Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family. (68 aa)
mru_0859Translation initiation factor aSUI1; Belongs to the SUI1 family. (114 aa)
rps17Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (106 aa)
rpl14Ribosomal protein L14P Rpl14p; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rpl24Ribosomal protein L24P Rpl24p; Located at the polypeptide exit tunnel on the outside of the subunit. (113 aa)
rps4eRibosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (244 aa)
rpl5pRibosomal protein L5P Rpl5p; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (173 aa)
rps14Ribosomal protein S14P Rps14p; Binds 16S rRNA, required for the assembly of 30S particles. (50 aa)
rps8pRibosomal protein S8P Rps8p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl6pRibosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
mru_0869Ribosomal protein L32e Rpl32e. (114 aa)
rpl19eRibosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl18Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rps5pRibosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (213 aa)
rpl30Ribosomal protein L30P Rpl30p. (152 aa)
rpl15Ribosomal protein L15P Rpl15p; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpl34eRibosomal protein L34e Rpl34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
mru_0880Ribosomal protein L14e Rpl14e. (55 aa)
rps13Ribosomal protein S13P Rps13p; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
rps4pRibosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (178 aa)
rps11Ribosomal protein S11P Rps11p; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
rpl18eRibosomal protein L18e Rpl18e; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rpl13Ribosomal protein L13P Rpl13p; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rps9pRibosomal protein S9P Rps9p; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rps2pRibosomal protein S2P Rps2p; Belongs to the universal ribosomal protein uS2 family. (198 aa)
gltXglutamyl-tRNA synthetase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (556 aa)
proSprolyl-tRNA synthetase ProS; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (468 aa)
rpl40eRibosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family. (53 aa)
rpl37eRibosomal protein L37e Rpl37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (61 aa)
rpl15eRibosomal protein L15e Rpl15e; Belongs to the eukaryotic ribosomal protein eL15 family. (183 aa)
mru_1474Hypothetical protein. (103 aa)
rps24eRibosomal protein S24e Rps24e; Belongs to the eukaryotic ribosomal protein eS24 family. (104 aa)
eif2gTranslation initiation factor aIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (407 aa)
rps6eRibosomal protein S6e Rps6e; Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rps28eRibosomal protein S28e Rps28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
rpl7aeRibosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (135 aa)
rps17eRibosomal protein S17e Rps17e; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
rps10Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
tufTranslation elongation factor aEF-1 alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (413 aa)
fusA-2Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (735 aa)
rps7pRibosomal protein S7P Rps7p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa)
rps12Ribosomal protein S12P Rps12p; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa)
rpl30eRibosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
eif1aTranslation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (106 aa)
rpl10eRibosomal protein L10e Rpl10e; Belongs to the universal ribosomal protein uL16 family. (160 aa)
mapMethionine aminopeptidase Map; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (309 aa)
rps15Ribosomal protein S15P Rps15p. (132 aa)
Your Current Organism:
Methanobrevibacter ruminantium
NCBI taxonomy Id: 634498
Other names: M. ruminantium M1, Methanobrevibacter ruminantium M1, Methanobrevibacter ruminantium str. M1, Methanobrevibacter ruminantium strain M1
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