STRINGSTRING
mru_0828 mru_0828 mru_0001 mru_0001 mru_0011 mru_0011 mru_0021 mru_0021 mru_0066 mru_0066 mru_0071 mru_0071 mru_0080 mru_0080 sdhA sdhA mru_0095 mru_0095 mru_0114 mru_0114 radA radA mru_0116 mru_0116 glyA glyA mru_0133 mru_0133 mru_0141 mru_0141 argD argD lysA lysA ksgA ksgA rpl21e rpl21e rpl44e rpl44e nop10 nop10 mru_0183 mru_0183 dsbD dsbD mru_0185 mru_0185 mru_0243 mru_0243 mru_0259 mru_0259 mru_0280 mru_0280 mru_0306 mru_0306 fen fen aksA aksA cyaA cyaA tbp tbp mru_0391 mru_0391 mru_0393 mru_0393 rps19e rps19e rpl31e rpl31e rplX rplX ftsY ftsY mru_0414 mru_0414 mru_0415 mru_0415 mru_0423 mru_0423 mru_0433 mru_0433 mru_0443 mru_0443 dnll dnll mru_0460 mru_0460 rps3ae rps3ae tfe tfe rpl11 rpl11 rpl1p rpl1p rplPO rplPO rpl12 rpl12 mru_0493 mru_0493 radB radB mru_0511 mru_0511 mru_0515 mru_0515 mru_0517 mru_0517 bioB2 bioB2 mru_0560 mru_0560 mru_0589 mru_0589 mru_0598 mru_0598 cobB cobB rnz rnz mru_0620 mru_0620 ubiB1 ubiB1 mru_0627 mru_0627 mru_0633 mru_0633 mru_0674 mru_0674 mru_0691 mru_0691 ahaF ahaF dnaG dnaG gar1 gar1 ubiB2 ubiB2 mru_0749 mru_0749 mru_0774 mru_0774 mru_0778 mru_0778 mru_0806 mru_0806 mru_0821 mru_0821 mru_0824 mru_0824 mru_0827 mru_0827 mru_0842 mru_0842 mru_0843 mru_0843 mru_0850 mru_0850 rpl3p rpl3p rpl23 rpl23 rps19p rps19p rpl22 rpl22 rps3p rps3p rpl29 rpl29 rps17 rps17 rpl14 rpl14 rpl24 rpl24 rps4e rps4e rpl5p rpl5p rps14 rps14 rps8p rps8p rpl6p rpl6p mru_0869 mru_0869 rpl19e rpl19e rpl18 rpl18 rps5p rps5p rpl34e rpl34e mru_0880 mru_0880 cbiK cbiK cbf5p cbf5p rps13 rps13 rps4p rps4p rpl18e rpl18e rps9p rps9p rps2p rps2p fni fni mru_0930 mru_0930 nox nox priB priB priA priA npdG1 npdG1 hisD hisD argJ argJ argB argB fabG1 fabG1 mru_1032 mru_1032 pyrF pyrF mru_1072 mru_1072 hmgA hmgA rpl40e rpl40e mre11 mre11 rad50 rad50 mru_1110 mru_1110 mru_1121 mru_1121 rfcL rfcL rfcS rfcS mru_1131 mru_1131 mru_1135 mru_1135 mru_1136 mru_1136 mru_1148 mru_1148 mru_1157 mru_1157 mru_1173 mru_1173 mru_1185 mru_1185 mru_1274 mru_1274 ubiX ubiX mru_1284 mru_1284 mru_1286 mru_1286 dagK dagK mru_1298 mru_1298 mru_1305 mru_1305 mru_1308 mru_1308 mru_1328 mru_1328 mru_1341 mru_1341 mru_1349 mru_1349 rpl37ae rpl37ae mru_1355 mru_1355 rpl15e rpl15e mru_1374 mru_1374 mru_1387 mru_1387 cimA cimA mru_1441 mru_1441 npdG2 npdG2 mru_1449 mru_1449 mru_1455 mru_1455 mru_1466 mru_1466 mru_1471 mru_1471 mru_1474 mru_1474 rps24e rps24e rps6e rps6e rpl24e rpl24e rps28e rps28e mru_1491 mru_1491 endA endA mru_1499 mru_1499 rps8e rps8e polB2 polB2 mru_1554 mru_1554 mru_1562 mru_1562 mru_1567 mru_1567 mru_1569 mru_1569 nth nth ubiB3 ubiB3 mru_1580 mru_1580 mru_1589 mru_1589 mru_1604 mru_1604 fabG2 fabG2 mru_1640 mru_1640 mru_1668 mru_1668 rps17e rps17e hel308 hel308 mru_1683 mru_1683 mru_1686 mru_1686 mru_1687 mru_1687 truA truA nudC nudC argC argC mru_1728 mru_1728 mru_1729 mru_1729 mru_1731 mru_1731 mru_1760 mru_1760 mru_1767 mru_1767 mru_1784 mru_1784 mru_1798 mru_1798 mru_1799 mru_1799 mru_1802 mru_1802 rps10 rps10 rps7p rps7p rps12 rps12 rpl30e rpl30e mru_1812 mru_1812 taw1 taw1 mru_1848 mru_1848 hemA hemA mru_1855 mru_1855 top6A top6A neuB neuB mru_1885 mru_1885 rpl10e rpl10e sufBD sufBD mru_1913 mru_1913 gpxA gpxA mru_1950 mru_1950 mru_1958 mru_1958 ubiB4 ubiB4 taw2 taw2 polB1 polB1 pyrK pyrK mru_1987 mru_1987 flpA flpA pheA pheA mru_2028 mru_2028 grpE grpE dnaK dnaK dnaJ dnaJ bchH bchH mru_2070 mru_2070 bioB1 bioB1 rps15 rps15 mru_2118 mru_2118 ilvD ilvD mru_2120 mru_2120 hcp hcp mru_2122 mru_2122 mru_2140 mru_2140 leuA leuA mru_2171 mru_2171 mru_2196 mru_2196 cbiX cbiX mru_2201 mru_2201
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mru_0828Adhesin-like protein with transglutaminase domain. (782 aa)
mru_0001Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (388 aa)
mru_0011Archaeal histone. (67 aa)
mru_0021Hypothetical protein. (185 aa)
mru_0066Serine phosphatase. (623 aa)
mru_0071Serine phosphatase. (353 aa)
mru_0080Hypothetical protein. (486 aa)
sdhASuccinate dehydrogenase/fumarate reductase flavoprotein subunit SdhA. (551 aa)
mru_0095Isoprenylcysteine carboxyl methyltransferase family protein. (223 aa)
mru_0114Replication factor A. (823 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (311 aa)
mru_0116Transporter. (305 aa)
glyASerine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa)
mru_0133ATP-dependent DNA helicase. (660 aa)
mru_0141Transporter. (338 aa)
argDAcetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (391 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
ksgADimethyladenosine transferase KsgA; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (298 aa)
rpl21eRibosomal protein L21e Rpl21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
nop10H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa)
mru_0183Protein disulfide-isomerase thioredoxin-related protein. (206 aa)
dsbDCytochrome C-type biogenesis protein DsbD. (205 aa)
mru_0185Hypothetical protein. (230 aa)
mru_0243Hypothetical protein. (286 aa)
mru_0259Cdc6 family replication initiation protein Cdc6-3. (275 aa)
mru_0280ParB-like nuclease domain-containing protein. (206 aa)
mru_0306Hypothetical protein. (231 aa)
fenFlap endonuclease Fen; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] (328 aa)
aksAHomocitrate synthase AksA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (392 aa)
cyaAAdenylate cyclase CyaA. (181 aa)
tbpTATA-box binding protein Tbp; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (181 aa)
mru_0391Oligosaccharyl transferase. (900 aa)
mru_0393Hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (200 aa)
rps19eRibosomal protein S19e Rps19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
rpl31eRibosomal protein L31e Rpl31e; Belongs to the ribosomal protein L31e family. (86 aa)
rplXRibosomal protein LX RplX. (74 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (576 aa)
mru_0414Aminotransferase class V family. (388 aa)
mru_0415Calcineurin-like phosphoesterase. (366 aa)
mru_0423Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa)
mru_0433Dolichol kinase. (229 aa)
mru_0443Short-chain dehydrogenase family protein. (256 aa)
dnllATP-dependent DNA ligase DnlI; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (550 aa)
mru_0460Hypothetical protein. (232 aa)
rps3aeRibosomal protein S3Ae Rps3ae; Belongs to the eukaryotic ribosomal protein eS1 family. (192 aa)
tfeTranscription initiation factor TFIIE alpha subunit Tfe; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabili [...] (357 aa)
rpl11Ribosomal protein L11P Rpl11p; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa)
rpl1pRibosomal protein L1P Rpl1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rplPOAcidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (335 aa)
rpl12Ribosomal protein L12P Rpl12p; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (103 aa)
mru_0493Adhesin-like protein. (815 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (231 aa)
mru_0511Hydrolase alpha/beta fold family. (304 aa)
mru_0515Serine phosphatase. (624 aa)
mru_0517TfoX N-terminal domain-containing protein. (105 aa)
bioB2Biotin synthase BioB2. (333 aa)
mru_0560ATPase. (290 aa)
mru_0589NMD3 family protein. (346 aa)
mru_0598Band 7 family protein. (322 aa)
cobBNAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (241 aa)
rnzRibonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (303 aa)
mru_0620Helicase SNF2 family. (698 aa)
ubiB12-polyprenylphenol 6- hydroxylase UbiB1. (171 aa)
mru_0627ZPR1 zinc-finger domain-containing protein. (199 aa)
mru_0633Acetyltransferase GNAT family. (169 aa)
mru_0674Hypothetical protein. (138 aa)
mru_06912-methylcitrate synthase/citrate synthase II PrpC/CitZ. (282 aa)
ahaFA1A0 archaeal ATP synthase subunit F AhaF; Produces ATP from ADP in the presence of a proton gradient across the membrane. (105 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (445 aa)
gar1H/ACA RNA-protein complex component Gar1. (120 aa)
ubiB22-polyprenylphenol 6- hydroxylase UbiB2. (530 aa)
mru_0749ADP-ribosylglycohydrolase family protein. (337 aa)
mru_0774Archaeal histone. (66 aa)
mru_0778DEAD/DEAH box helicase domain-containing protein. (808 aa)
mru_0806Hypothetical protein. (226 aa)
mru_0821Transporter CDF family. (383 aa)
mru_0824Adhesin-like protein with transglutaminase domain. (675 aa)
mru_0827Transporter CDF family. (304 aa)
mru_0842Adhesin-like protein with cysteine protease domain. (1325 aa)
mru_0843Adhesin-like protein with cysteine protease domain. (2065 aa)
mru_0850Hypothetical protein. (271 aa)
rpl3pRibosomal protein L3P Rpl3p; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa)
rpl23Ribosomal protein L23P Rpl23p; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rps19pRibosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rpl22Ribosomal protein L22P Rpl22p; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (155 aa)
rps3pRibosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (251 aa)
rpl29Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rps17Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (106 aa)
rpl14Ribosomal protein L14P Rpl14p; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rpl24Ribosomal protein L24P Rpl24p; Located at the polypeptide exit tunnel on the outside of the subunit. (113 aa)
rps4eRibosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (244 aa)
rpl5pRibosomal protein L5P Rpl5p; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (173 aa)
rps14Ribosomal protein S14P Rps14p; Binds 16S rRNA, required for the assembly of 30S particles. (50 aa)
rps8pRibosomal protein S8P Rps8p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl6pRibosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
mru_0869Ribosomal protein L32e Rpl32e. (114 aa)
rpl19eRibosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl18Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rps5pRibosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (213 aa)
rpl34eRibosomal protein L34e Rpl34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
mru_0880Ribosomal protein L14e Rpl14e. (55 aa)
cbiKCobalt chelatase CbiK. (262 aa)
cbf5pH/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa)
rps13Ribosomal protein S13P Rps13p; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
rps4pRibosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (178 aa)
rpl18eRibosomal protein L18e Rpl18e; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rps9pRibosomal protein S9P Rps9p; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rps2pRibosomal protein S2P Rps2p; Belongs to the universal ribosomal protein uS2 family. (198 aa)
fniIsopentenyl diphosphate delta-isomerase Fni; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (350 aa)
mru_0930Hypothetical protein. (117 aa)
noxNADH oxidase Nox. (444 aa)
priBDNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (447 aa)
priADNA primase small subunit PriA; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (330 aa)
npdG1NADPH-dependent F420 reductase NpdG1. (227 aa)
hisDHistidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (397 aa)
argBAcetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa)
fabG13-oxoacyl-(acyl-carrier-protein) reductase FabG1. (247 aa)
mru_1032AMP-binding enzyme. (494 aa)
pyrFOrotidine 5'-phosphate decarboxylase PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa)
mru_1072Glycosyl transferase GT2 family. (817 aa)
hmgAhydroxymethylglutaryl-CoA reductase (NADPH) HmgA; Belongs to the HMG-CoA reductase family. (400 aa)
rpl40eRibosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family. (53 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (463 aa)
rad50DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (932 aa)
mru_1110DEAD/DEAH box helicase domain-containing protein. (918 aa)
mru_1121DNA helicase. (2632 aa)
rfcLReplication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (530 aa)
rfcSReplication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (314 aa)
mru_1131Hypothetical protein. (493 aa)
mru_1135Restriction endonuclease. (244 aa)
mru_1136Hypothetical protein. (399 aa)
mru_1148O-acetylhomoserine/O-acetylserine sulfhydrylase MetZ/CysK1. (428 aa)
mru_1157Helicase RecD/TraA family. (611 aa)
mru_1173Hypothetical protein. (629 aa)
mru_1185Hypothetical protein. (398 aa)
mru_1274HD domain-containing protein. (407 aa)
ubiX3-polyprenyl-4-hydroxybenzoate decarboxylase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (184 aa)
mru_1284RNA-binding protein. (181 aa)
mru_1286CMP/dCMP deaminase. (149 aa)
dagKDiacylglycerol kinase DagK. (119 aa)
mru_1298Archaeal ATPase. (394 aa)
mru_1305DnaK-related protein; Belongs to the heat shock protein 70 family. (761 aa)
mru_1308FHA domain-containing protein. (267 aa)
mru_1328acyl-CoA synthetase. (554 aa)
mru_1341Geranylgeranyl reductase family protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (398 aa)
mru_1349Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (163 aa)
rpl37aeRibosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (89 aa)
mru_1355Exosome subunit. (234 aa)
rpl15eRibosomal protein L15e Rpl15e; Belongs to the eukaryotic ribosomal protein eL15 family. (183 aa)
mru_1374Acetyltransferase GNAT family. (159 aa)
mru_1387Adhesin-like protein with cysteine protease domain. (985 aa)
cimACitramalate synthase CimA; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (497 aa)
mru_1441Geranylgeranyl reductase family protein. (432 aa)
npdG2NADPH-dependent F420 reductase NpdG2. (227 aa)
mru_1449Transcriptional regulator. (167 aa)
mru_1455ADP-ribosylglycohydrolase family protein. (348 aa)
mru_14664Fe-4S iron sulfur cluster binding protein NifH/frxC family; Belongs to the NifH/BchL/ChlL family. (267 aa)
mru_1471Geranylgeranyl reductase family protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (396 aa)
mru_1474Hypothetical protein. (103 aa)
rps24eRibosomal protein S24e Rps24e; Belongs to the eukaryotic ribosomal protein eS24 family. (104 aa)
rps6eRibosomal protein S6e Rps6e; Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rps28eRibosomal protein S28e Rps28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
mru_1491Archaeal histone. (65 aa)
endAtRNA intron endonuclease EndA. (171 aa)
mru_1499Adhesin-like protein with transglutaminase domain. (1010 aa)
rps8eRibosomal protein S8e Rps8e. (125 aa)
polB2DNA polymerase family B PolB2. (226 aa)
mru_1554Hydrolase HAD superfamily. (226 aa)
mru_1562Metallo-beta-lactamase superfamily protein. (313 aa)
mru_1567NifU-like FeS cluster assembly scaffold protein. (124 aa)
mru_1569O-acetylhomoserine/O-acetylserine sulfhydrylase MetZ/CysK2. (439 aa)
nthEndonuclease III Nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa)
ubiB32-polyprenylphenol 6- hydroxylase UbiB3. (539 aa)
mru_1580ADP-ribosylglycohydrolase family protein. (261 aa)
mru_1589Hypothetical protein. (142 aa)
mru_1604Adhesin-like protein with transglutaminase domain. (998 aa)
fabG23-oxoacyl-(acyl-carrier-protein) reductase FabG2. (245 aa)
mru_1640hydroxymethylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (346 aa)
mru_1668Hypothetical protein. (252 aa)
rps17eRibosomal protein S17e Rps17e; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
hel308DEAD/DEAH box helicase domain-containing protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (690 aa)
mru_1683Hypothetical protein. (151 aa)
mru_1686Archaeal histone. (66 aa)
mru_1687MiaB-like tRNA modifying enzyme. (428 aa)
truAtRNA pseudouridine synthase A TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (290 aa)
nudCNADH pyrophosphatase NudC. (298 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (338 aa)
mru_1728AMMECR1 domain-containing protein. (185 aa)
mru_1729GTP-binding protein. (351 aa)
mru_1731Archaeal histone. (67 aa)
mru_1760Archaeal histone. (111 aa)
mru_1767Met-10+ like-protein. (365 aa)
mru_1784Hypothetical protein. (94 aa)
mru_1798Adhesin-like protein. (472 aa)
mru_1799Hypothetical protein. (309 aa)
mru_1802Cation-transporting P-type ATPase. (906 aa)
rps10Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rps7pRibosomal protein S7P Rps7p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa)
rps12Ribosomal protein S12P Rps12p; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa)
rpl30eRibosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
mru_1812DnaK-related protein; Belongs to the heat shock protein 70 family. (584 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (304 aa)
mru_1848TfoX C-terminal domain-containing protein. (85 aa)
hemAglutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (398 aa)
mru_1855Endonuclease IV. (278 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (362 aa)
neuBN-acetyl neuramic acid synthetase NeuB. (356 aa)
mru_1885Digeranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (293 aa)
rpl10eRibosomal protein L10e Rpl10e; Belongs to the universal ribosomal protein uL16 family. (160 aa)
sufBDFeS assembly protein SufBD. (407 aa)
mru_1913PRC-barrel domain-containing protein. (89 aa)
gpxAGlutathione peroxidase GpxA. (179 aa)
mru_1950TraB family protein. (388 aa)
mru_1958Short-chain dehydrogenase family protein. (157 aa)
ubiB42-polyprenylphenol 6- hydroxylase UbiB4. (529 aa)
taw2Met-10+ like-protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (256 aa)
polB1DNA polymerase family B PolB1. (638 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit PyrK. (269 aa)
mru_1987pre-mRNA splicing ribonucleoprotein PRP31. (426 aa)
flpAFibrillarin FlpA; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (216 aa)
pheAPrephenate dehydratase PheA. (275 aa)
mru_2028Radical SAM domain-containing protein. (343 aa)
grpEMolecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] (230 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone. (631 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (391 aa)
bchHMagnesium chelatase H subunit BchH. (1875 aa)
mru_2070ATPase. (335 aa)
bioB1Biotin synthase BioB1; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (326 aa)
rps15Ribosomal protein S15P Rps15p. (132 aa)
mru_2118Signal peptidase I. (137 aa)
ilvDDihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (551 aa)
mru_2120Hypothetical protein. (107 aa)
hcpHydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (432 aa)
mru_2122Transcriptional regulator. (264 aa)
mru_2140Archaeal ATPase. (406 aa)
leuA2-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa)
mru_2171Hypothetical protein. (287 aa)
mru_2196Hypothetical protein. (106 aa)
cbiXCobalamin biosynthesis protein CbiX. (322 aa)
mru_2201Hypothetical protein. (132 aa)
Your Current Organism:
Methanobrevibacter ruminantium
NCBI taxonomy Id: 634498
Other names: M. ruminantium M1, Methanobrevibacter ruminantium M1, Methanobrevibacter ruminantium str. M1, Methanobrevibacter ruminantium strain M1
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