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mru_1308 mru_1308 mru_0001 mru_0001 mru_0011 mru_0011 mru_0080 mru_0080 rpl21e rpl21e rpl44e rpl44e nop10 nop10 mru_0243 mru_0243 mru_0259 mru_0259 mru_0280 mru_0280 mru_0306 mru_0306 cyaA cyaA rps19e rps19e rpl31e rpl31e mru_0415 mru_0415 mru_0423 mru_0423 rps3ae rps3ae rplPO rplPO rpl12 rpl12 mru_0493 mru_0493 mru_0511 mru_0511 mru_0517 mru_0517 mru_0560 mru_0560 cobB cobB dnaG dnaG gar1 gar1 mru_0749 mru_0749 mru_0774 mru_0774 mru_0806 mru_0806 mru_0824 mru_0824 mru_0828 mru_0828 mru_0850 mru_0850 rps19p rps19p rps3p rps3p rpl29 rpl29 rps17 rps17 rps4e rps4e rpl6p rpl6p mru_0869 mru_0869 rpl19e rpl19e rpl18 rpl18 rps5p rps5p rpl34e rpl34e cbf5p cbf5p rps4p rps4p rps9p rps9p rps2p rps2p mru_0930 mru_0930 priB priB priA priA mru_1072 mru_1072 rpl40e rpl40e mre11 mre11 rad50 rad50 rfcL rfcL rfcS rfcS mru_1131 mru_1131 mru_1135 mru_1135 mru_1136 mru_1136 mru_1173 mru_1173 mru_1185 mru_1185 mru_1274 mru_1274 mru_1286 mru_1286 dagK dagK mru_1298 mru_1298 rpl37ae rpl37ae rpl15e rpl15e mru_1455 mru_1455 mru_1474 mru_1474 rps24e rps24e rps6e rps6e rpl24e rpl24e rps28e rps28e mru_1491 mru_1491 mru_1499 mru_1499 nth nth mru_1580 mru_1580 mru_1604 mru_1604 mru_1668 mru_1668 rps17e rps17e mru_1686 mru_1686 mru_1729 mru_1729 mru_1731 mru_1731 mru_1760 mru_1760 mru_1798 mru_1798 mru_1799 mru_1799 rps10 rps10 rpl30e rpl30e mru_1848 mru_1848 top6A top6A neuB neuB mru_1987 mru_1987 flpA flpA dnaJ dnaJ mru_2122 mru_2122 mru_2140 mru_2140 mru_2171 mru_2171 mru_2196 mru_2196
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mru_1308FHA domain-containing protein. (267 aa)
mru_0001Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (388 aa)
mru_0011Archaeal histone. (67 aa)
mru_0080Hypothetical protein. (486 aa)
rpl21eRibosomal protein L21e Rpl21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
nop10H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa)
mru_0243Hypothetical protein. (286 aa)
mru_0259Cdc6 family replication initiation protein Cdc6-3. (275 aa)
mru_0280ParB-like nuclease domain-containing protein. (206 aa)
mru_0306Hypothetical protein. (231 aa)
cyaAAdenylate cyclase CyaA. (181 aa)
rps19eRibosomal protein S19e Rps19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
rpl31eRibosomal protein L31e Rpl31e; Belongs to the ribosomal protein L31e family. (86 aa)
mru_0415Calcineurin-like phosphoesterase. (366 aa)
mru_0423Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa)
rps3aeRibosomal protein S3Ae Rps3ae; Belongs to the eukaryotic ribosomal protein eS1 family. (192 aa)
rplPOAcidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (335 aa)
rpl12Ribosomal protein L12P Rpl12p; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (103 aa)
mru_0493Adhesin-like protein. (815 aa)
mru_0511Hydrolase alpha/beta fold family. (304 aa)
mru_0517TfoX N-terminal domain-containing protein. (105 aa)
mru_0560ATPase. (290 aa)
cobBNAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (241 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (445 aa)
gar1H/ACA RNA-protein complex component Gar1. (120 aa)
mru_0749ADP-ribosylglycohydrolase family protein. (337 aa)
mru_0774Archaeal histone. (66 aa)
mru_0806Hypothetical protein. (226 aa)
mru_0824Adhesin-like protein with transglutaminase domain. (675 aa)
mru_0828Adhesin-like protein with transglutaminase domain. (782 aa)
mru_0850Hypothetical protein. (271 aa)
rps19pRibosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rps3pRibosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (251 aa)
rpl29Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rps17Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (106 aa)
rps4eRibosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (244 aa)
rpl6pRibosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
mru_0869Ribosomal protein L32e Rpl32e. (114 aa)
rpl19eRibosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl18Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rps5pRibosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (213 aa)
rpl34eRibosomal protein L34e Rpl34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
cbf5pH/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa)
rps4pRibosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (178 aa)
rps9pRibosomal protein S9P Rps9p; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rps2pRibosomal protein S2P Rps2p; Belongs to the universal ribosomal protein uS2 family. (198 aa)
mru_0930Hypothetical protein. (117 aa)
priBDNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (447 aa)
priADNA primase small subunit PriA; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (330 aa)
mru_1072Glycosyl transferase GT2 family. (817 aa)
rpl40eRibosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family. (53 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (463 aa)
rad50DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (932 aa)
rfcLReplication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (530 aa)
rfcSReplication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (314 aa)
mru_1131Hypothetical protein. (493 aa)
mru_1135Restriction endonuclease. (244 aa)
mru_1136Hypothetical protein. (399 aa)
mru_1173Hypothetical protein. (629 aa)
mru_1185Hypothetical protein. (398 aa)
mru_1274HD domain-containing protein. (407 aa)
mru_1286CMP/dCMP deaminase. (149 aa)
dagKDiacylglycerol kinase DagK. (119 aa)
mru_1298Archaeal ATPase. (394 aa)
rpl37aeRibosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (89 aa)
rpl15eRibosomal protein L15e Rpl15e; Belongs to the eukaryotic ribosomal protein eL15 family. (183 aa)
mru_1455ADP-ribosylglycohydrolase family protein. (348 aa)
mru_1474Hypothetical protein. (103 aa)
rps24eRibosomal protein S24e Rps24e; Belongs to the eukaryotic ribosomal protein eS24 family. (104 aa)
rps6eRibosomal protein S6e Rps6e; Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rps28eRibosomal protein S28e Rps28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
mru_1491Archaeal histone. (65 aa)
mru_1499Adhesin-like protein with transglutaminase domain. (1010 aa)
nthEndonuclease III Nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa)
mru_1580ADP-ribosylglycohydrolase family protein. (261 aa)
mru_1604Adhesin-like protein with transglutaminase domain. (998 aa)
mru_1668Hypothetical protein. (252 aa)
rps17eRibosomal protein S17e Rps17e; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
mru_1686Archaeal histone. (66 aa)
mru_1729GTP-binding protein. (351 aa)
mru_1731Archaeal histone. (67 aa)
mru_1760Archaeal histone. (111 aa)
mru_1798Adhesin-like protein. (472 aa)
mru_1799Hypothetical protein. (309 aa)
rps10Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpl30eRibosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
mru_1848TfoX C-terminal domain-containing protein. (85 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (362 aa)
neuBN-acetyl neuramic acid synthetase NeuB. (356 aa)
mru_1987pre-mRNA splicing ribonucleoprotein PRP31. (426 aa)
flpAFibrillarin FlpA; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (216 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (391 aa)
mru_2122Transcriptional regulator. (264 aa)
mru_2140Archaeal ATPase. (406 aa)
mru_2171Hypothetical protein. (287 aa)
mru_2196Hypothetical protein. (106 aa)
Your Current Organism:
Methanobrevibacter ruminantium
NCBI taxonomy Id: 634498
Other names: M. ruminantium M1, Methanobrevibacter ruminantium M1, Methanobrevibacter ruminantium str. M1, Methanobrevibacter ruminantium strain M1
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