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| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (362 aa) |
| | ADG80909.1 | KEGG: pth:PTH_0012 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (523 aa) |
| | ADG80923.1 | Methionine synthase; KEGG: mta:Moth_1208 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein. (211 aa) |
| | ADG80926.1 | PFAM: aminoglycoside phosphotransferase; KEGG: pca:Pcar_0939 putative homoserine kinase type II. (402 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (186 aa) |
| | ADG80952.1 | PFAM: aminoglycoside phosphotransferase; KEGG: pca:Pcar_0939 putative homoserine kinase type II. (401 aa) |
| | ADG80955.1 | PFAM: dihydropteroate synthase DHPS; KEGG: dol:Dole_2853 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase. (265 aa) |
| | ADG80956.1 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sat:SYN_00311 phosphatases. (212 aa) |
| | ADG80967.1 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: tte:TTE1013 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (339 aa) |
| | ADG80968.1 | KEGG: pth:PTH_0518 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase, type II. (387 aa) |
| | ADG80972.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: drm:Dred_2825 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (361 aa) |
| | ADG80973.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: chy:CHY_0044 putative keto/oxoacid ferredoxin oxidoreductase, beta subunit. (253 aa) |
| | ADG80974.1 | KEGG: chy:CHY_0045 putative keto/oxoacid ferredoxin oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (188 aa) |
| | ADG80975.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: adg:Adeg_2122 4Fe-4S ferredoxin iron-sulfur binding domain protein. (81 aa) |
| | ADG80977.1 | PFAM: peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; KEGG: bpu:BPUM_0387 choloylglycine hydrolase. (380 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (306 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (218 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (279 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (278 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | ADG81110.1 | Von Willebrand factor type A; KEGG: swo:Swol_0446 Mg-chelatase subunit ChlD-like protein; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A. (584 aa) |
| | ADG81111.1 | KEGG: swo:Swol_0445 magnesium chelatase; SMART: AAA ATPase. (380 aa) |
| | ADG81122.1 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: dsy:DSY2898 putative fumarate reductase flavoprotein subunit. (570 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (234 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | ADG81156.1 | TIGRFAM: serine O-acetyltransferase; KEGG: mta:Moth_2485 serine O-acetyltransferase. (228 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (400 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD | Manually curated; TIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: hmo:HM1_1431 acetylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa) |
| | ADG81239.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: hmo:HM1_1436 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | argH | KEGG: drm:Dred_0278 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (463 aa) |
| | ADG81243.1 | TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; KEGG: drm:Dred_1940 aspartate kinase I; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (406 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: pth:PTH_0526 dihydroxyacid dehydratase/phosphogluconate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | ADG81246.1 | KEGG: adg:Adeg_0223 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (553 aa) |
| | ADG81247.1 | KEGG: chy:CHY_0518 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (183 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa) |
| | ADG81253.1 | KEGG: drm:Dred_0289 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (642 aa) |
| | acsA-2 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (641 aa) |
| | ADG81257.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: hmo:HM1_0951 acetyl-coenzyme a synthetase. (573 aa) |
| | ADG81375.1 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (296 aa) |
| | ADG81403.1 | PFAM: Methyltransferase type 11; KEGG: aac:Aaci_2021 methyltransferase type 11. (245 aa) |
| | ADG81422.1 | KEGG: dat:HRM2_15640 radical SAM domain protein (Fe-S oxidoreductase); PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (500 aa) |
| | ADG81423.1 | KEGG: dat:HRM2_15650 radical SAM domain protein (Fe-S oxidoreductase); PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (454 aa) |
| | ADG81511.1 | TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: cno:NT01CX_0001 histidinol-phosphatase, putative; SMART: phosphoesterase PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (259 aa) |
| | ADG81535.1 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: dau:Daud_0140 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (614 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (334 aa) |
| | ADG81643.1 | KEGG: pth:PTH_0247 cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | ADG81653.1 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: mta:Moth_2106 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | ADG81689.1 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cth:Cthe_0554 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. (1257 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | ADG81692.1 | KEGG: pth:PTH_2547 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: drm:Dred_2369 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (239 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (484 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; manually curated; KEGG: drm:Dred_2364 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase. (353 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: pth:PTH_2541 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (514 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: pth:PTH_2540 phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (422 aa) |
| | hisZ | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (393 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (217 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisC | KEGG: pth:PTH_2537 histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | hisB | KEGG: pth:PTH_2536 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (203 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: pth:PTH_2533 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (241 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; KEGG: gka:GK3070 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (224 aa) |
| | ADG81722.1 | PFAM: iron-containing alcohol dehydrogenase; KEGG: dae:Dtox_2962 iron-containing alcohol dehydrogenase. (386 aa) |
| | ADG81742.1 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: aac:Aaci_2348 isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (431 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) |
| | ADG81751.1 | PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; KEGG: dae:Dtox_0788 nucleotidyl transferase. (838 aa) |
| | ADG81752.1 | PFAM: Domain of unknown function DUF1957; glycoside hydrolase family 57; KEGG: dae:Dtox_0801 domain of unknown function DUF1957; Belongs to the glycosyl hydrolase 57 family. (540 aa) |
| | ADG81772.1 | KEGG: pca:Pcar_2593 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (347 aa) |
| | ADG81774.1 | Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (811 aa) |
| | ADG81795.1 | PFAM: Di-trans-poly-cis-decaprenylcistransferase; KEGG: hor:Hore_14480 di-trans-poly-cis-decaprenylcistransferase. (225 aa) |
| | ADG81800.1 | TIGRFAM: threonine synthase; KEGG: cce:Ccel_1450 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (499 aa) |
| | ADG81975.1 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: pth:PTH_1584 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (902 aa) |
| | ADG81978.1 | TIGRFAM: alpha-glucan phosphorylase; KEGG: hmo:HM1_2568 alpha-glucan phosphorylase; PFAM: glycosyl transferase family 35. (556 aa) |
| | ADG81980.1 | KEGG: dae:Dtox_1248 trans-hexaprenyltranstransferase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (323 aa) |
| | ADG81991.1 | KEGG: geo:Geob_0066 radical SAM domain protein; PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (1005 aa) |
| | ADG81997.1 | KEGG: pth:PTH_0970 siroheme synthase; TIGRFAM: siroheme synthase. (215 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (458 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | ADG82000.1 | KEGG: dae:Dtox_1252 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4. (505 aa) |
| | ADG82001.1 | Radical SAM domain protein; KEGG: pth:PTH_0974 Fe-S oxidoreductases; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (391 aa) |
| | ADG82002.1 | Porphobilinogen synthase; KEGG: pth:PTH_0975 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa) |
| | ADG82003.1 | KEGG: amt:Amet_0051 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (331 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: chy:CHY_1212 glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (455 aa) |
| | ADG82130.1 | PFAM: NAD(P)H dehydrogenase (quinone); KEGG: amt:Amet_3652 NAD(P)H dehydrogenase (quinone). (202 aa) |
| | ADG82146.1 | PFAM: aminotransferase class I and II; KEGG: pth:PTH_1308 aspartate/tyrosine/aromatic aminotransferase. (388 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | ADG82219.1 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa) |
| | ADG82220.1 | PFAM: phosphatidate cytidylyltransferase; KEGG: pth:PTH_1258 CDP-diglyceride synthetase; Belongs to the CDS family. (262 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (381 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (355 aa) |
| | ADG82238.1 | KEGG: pth:PTH_1273 FAD synthase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (313 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | ADG82257.1 | TIGRFAM: aspartate kinase; KEGG: drm:Dred_1940 aspartate kinase I; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (406 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (316 aa) |
| | ADG82357.1 | TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; KEGG: hor:Hore_10050 fumarate hydratase, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region. (282 aa) |
| | ADG82358.1 | KEGG: nis:NIS_0837 fumarate/tartrate hydratase, beta subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (189 aa) |
| | ADG82427.1 | KEGG: chy:CHY_1234 histidinol phosphate phosphatase family protein; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (301 aa) |
| | gpsA | KEGG: pth:PTH_1607 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (345 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (674 aa) |
| | ADG82443.1 | TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase; KEGG: drm:Dred_1153 1-acyl-sn-glycerol-3-phosphate acyltransferase; SMART: phospholipid/glycerol acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (193 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | ADG82450.1 | PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; KEGG: dau:Daud_1182 prephenate dehydrogenase. (369 aa) |
| | ADG82451.1 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: pth:PTH_1622 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | ADG82452.1 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: tpd:Teth39_0984 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (288 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpF | KEGG: gem:GM21_2257 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (208 aa) |
| | trpC | KEGG: pca:Pcar_0733 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (488 aa) |
| | ADG82460.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (123 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (446 aa) |
| | ADG82513.1 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa) |
| | ADG82525.1 | PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: hmo:HM1_0360 ketoisovalerate oxidoreductase. (182 aa) |
| | ADG82526.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: hor:Hore_06790 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), beta subunit. (249 aa) |
| | ADG82527.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: hor:Hore_06780 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), alpha subunit. (353 aa) |
| | ADG82528.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: pth:PTH_1204 ferredoxin. (72 aa) |
| | ADG82530.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: cth:Cthe_0551 AMP-dependent synthetase and ligase. (553 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa) |
| | ADG82550.1 | PFAM: Polyprenyl synthetase; KEGG: hmo:HM1_0293 geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (299 aa) |
| | ADG82556.1 | KEGG: chy:CHY_1991 putative oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (462 aa) |
| | ADG82568.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (384 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (293 aa) |
| | mqnC | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (352 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (283 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (367 aa) |
| | ADG82622.1 | KEGG: pth:PTH_1437 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; Belongs to the UbiA prenyltransferase family. (290 aa) |
| | menG | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (526 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (408 aa) |
| | ADG82631.1 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: pth:PTH_1760 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (219 aa) |
| | ADG82632.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (385 aa) |
| | ADG82634.1 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: drm:Dred_1716 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (222 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (390 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | ADG82766.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: hmo:HM1_0951 acetyl-coenzyme a synthetase. (565 aa) |
| | ADG82775.1 | Coproporphyrinogen dehydrogenase; PFAM: Radical SAM domain protein; KEGG: drm:Dred_2881 coproporphyrinogen III oxidase; SMART: Elongator protein 3/MiaB/NifB. (500 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (255 aa) |
| | ADG82806.1 | KEGG: hmo:HM1_2544 cdp-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (170 aa) |
| | psd | Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (214 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | menG-2 | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (240 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa) |
| | ADG82919.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | ADG82920.1 | KEGG: drm:Dred_2073 malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (313 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (302 aa) |
| | ADG82959.1 | KEGG: pth:PTH_1601 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (437 aa) |
| | ADG82960.1 | PFAM: amino acid-binding ACT domain protein; KEGG: dhd:Dhaf_3377 amino acid-binding ACT domain protein; Belongs to the UPF0735 family. (150 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | ADG83016.1 | TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: pth:PTH_1872 histidinol-phosphatase; SMART: phosphoesterase PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (267 aa) |
| | ADG83020.1 | PFAM: diacylglycerol kinase; KEGG: ckr:CKR_0827 hypothetical protein. (120 aa) |
| | ADG83026.1 | PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; KEGG: bbe:BBR47_37850 probable mannose-1-phosphate guanyltransferase. (806 aa) |
| | ADG83027.1 | PFAM: Domain of unknown function DUF1957; glycoside hydrolase family 57; Starch synthase catalytic domain protein; glycosyl transferase group 1; KEGG: adg:Adeg_0201 domain of unknown function DUF1957; Belongs to the glycosyl hydrolase 57 family. (944 aa) |
| | ADG83059.1 | KEGG: geo:Geob_0066 radical SAM domain protein; PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (482 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | ADG83086.1 | KEGG: mta:Moth_1706 cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (318 aa) |
| | sat | TIGRFAM: sulfate adenylyltransferase; KEGG: pth:PTH_0241 ATP sulfurylase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (384 aa) |
| | ADG83131.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: pth:PTH_1062 acetyltransferase; Belongs to the acetyltransferase family. (150 aa) |
| | ADG83166.1 | KEGG: pth:PTH_2214 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; Belongs to the pyruvate kinase family. (583 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | ADG83173.1 | KEGG: tle:Tlet_1717 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (445 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (366 aa) |
| | ADG83195.1 | KEGG: hmo:HM1_0105 aconitate hydratase, putative; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein. (640 aa) |
| | glgA | Glycogen/starch synthase, ADP-glucose type; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (492 aa) |
| | glgA-2 | Glycogen/starch synthase, ADP-glucose type; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (495 aa) |
| | ADG83226.1 | PFAM: aminotransferase class I and II; KEGG: pth:PTH_1421 aspartate aminotransferase. (395 aa) |
| | ADG83239.1 | TIGRFAM: pyruvate, phosphate dikinase; KEGG: chy:CHY_0443 pyruvate phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; Belongs to the PEP-utilizing enzyme family. (887 aa) |
| | ADG83255.1 | PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: dvm:DvMF_0572 threonine aldolase. (346 aa) |
| | ADG83293.1 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (379 aa) |
| | ADG83433.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: nth:Nther_0025 4Fe-4S ferredoxin iron-sulfur binding domain protein. (103 aa) |
| | ADG83447.1 | KEGG: mta:Moth_1122 citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (452 aa) |
| | ADG83506.1 | KEGG: mta:Moth_1369 UDP-glucose pyrophosphorylase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase. (294 aa) |
| | ADG83508.1 | Trehalose-phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (249 aa) |
| | ADG83509.1 | Alpha,alpha-trehalose-phosphate synthase (UDP-forming); KEGG: pth:PTH_0560 trehalose-6-phosphate synthase; PFAM: glycosyl transferase family 20. (519 aa) |
| | ADG83526.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: cce:Ccel_1469 AMP-dependent synthetase and ligase. (557 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (521 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | pgk | KEGG: chy:CHY_0281 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | ADG83546.1 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: chy:CHY_0280 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | ADG83555.1 | PFAM: ROK family protein; KEGG: hor:Hore_16050 glucokinase. (324 aa) |
| | ADG83557.1 | TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; KEGG: csc:Csac_1187 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; sugar isomerase (SIS). (357 aa) |
| | ADG83596.1 | PFAM: Transketolase central region; Transketolase domain protein; KEGG: pth:PTH_2749 transketolase, C-terminal subunit. (312 aa) |
| | ADG83597.1 | PFAM: Transketolase domain protein; KEGG: pth:PTH_2750 transketolase, N-terminal subunit. (279 aa) |
| | ADG83662.1 | KEGG: tpd:Teth39_1623 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. (357 aa) |
| | ADG83683.1 | PFAM: Nucleotidyl transferase; KEGG: swo:Swol_2137 mannose-1-phosphate guanyltransferase. (251 aa) |
| | ADG83689.1 | KEGG: geo:Geob_0066 radical SAM domain protein; PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (490 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | ADG83731.1 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: pth:PTH_2825 ribose 5-phosphate isomerase RpiB; PFAM: Ribose/galactose isomerase. (149 aa) |
| | ADG83746.1 | TIGRFAM: fructose-1,6-bisphosphatase, class II; KEGG: dhd:Dhaf_4837 fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein. (321 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | ADG83749.1 | TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; KEGG: hmo:HM1_1076 fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II. (284 aa) |
| | ADG83798.1 | Branched-chain-amino-acid transaminase; KEGG: mka:MK1627 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (283 aa) |
