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| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (226 aa) |
| | adk-2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (183 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (137 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (482 aa) |
| | ACC82877.1 | Diguanylate cyclase with PAS/PAC and Chase2 sensors; KEGG: ana:all1219 hypothetical protein; TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; CHASE2 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (734 aa) |
| | ACC83069.1 | Hypothetical protein; KEGG: aor:AO090026000568 predicted protein Pfam: ATP-grasp_3 RimK PROSITE: ATP_GRASP. (423 aa) |
| | ACC83093.1 | PFAM: DRTGG domain protein; KEGG: ana:all4665 hypothetical protein. (364 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (317 aa) |
| | ACC83424.1 | SMART: phospholipid/glycerol acyltransferase; KEGG: ana:alr0790 hypothetical protein. (346 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | ACC83670.1 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: ana:all2303 dihydroorotase. (439 aa) |
| | ACC83893.1 | TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: ava:Ava_2653 inositol-5-monophosphate dehydrogenase. (387 aa) |
| | ACC83911.1 | D-hydantoinase; KEGG: ana:alr5010 D-hydantoinase. (499 aa) |
| | nadK-2 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (306 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: ava:Ava_1893 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1087 aa) |
| | ACC84116.1 | PFAM: phosphatidate cytidylyltransferase; KEGG: ava:Ava_1818 phosphatidate cytidylyltransferase; Belongs to the CDS family. (314 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (272 aa) |
| | ACC84224.1 | PFAM: NUDIX hydrolase; KEGG: ana:alr4993 hypothetical protein. (149 aa) |
| | ACC84242.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (398 aa) |
| | ACC84436.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: ava:Ava_2827 phospholipid/glycerol acyltransferase. (468 aa) |
| | ACC84543.1 | PFAM: thiamineS protein; KEGG: ana:asl4353 molybdenum cofactor biosynthesis protein D. (86 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (203 aa) |
| | ACC84545.1 | Deoxycytidine deaminase-like protein; KEGG: psp:PSPPH_0596 hypothetical protein. (231 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | ACC84588.1 | KEGG: mag:amb4350 predicted hydrolase of HD superfamily. (210 aa) |
| | purH | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region; KEGG: ava:Ava_3818 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (514 aa) |
| | ACC84674.1 | PFAM: phosphoribulokinase/uridine kinase; KEGG: ava:Ava_0169 phosphoribulokinase. (313 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (324 aa) |
| | ACC84752.1 | KEGG: ana:alr3525 phosphoribosylformylglycinamidine cyclo-ligase. (392 aa) |
| | panC/cmk | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (577 aa) |
| | ACC78894.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: ana:alr0234 unknown protein. (241 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (340 aa) |
| | ACC78902.1 | TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases; PFAM: phospholipid/glycerol acyltransferase; KEGG: ana:alr0241 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (225 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (340 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (447 aa) |
| | ACC79385.1 | KEGG: hch:HCH_06994 predicted ATPase/kinase involved in NAD metabolism. (342 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (788 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (499 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (459 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (376 aa) |
| | ACC79675.1 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: ana:alr4848 riboflavin kinase/FAD synthase; Belongs to the ribF family. (349 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: ava:Ava_1163 NAD-dependent glycerol-3-phosphate dehydrogenase-like; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (309 aa) |
| | ACC79885.1 | PFAM: inositol monophosphatase; KEGG: ava:Ava_0983 inositol monophosphatase. (270 aa) |
| | ACC80057.1 | PFAM: diacylglycerol kinase; KEGG: ava:Ava_2781 prokaryotic diacylglycerol kinase. (151 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa) |
| | ACC80549.1 | KEGG: ana:all3029 hypothetical protein. (133 aa) |
| | ACC80905.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: hch:HCH_05595 hypothetical protein. (136 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (338 aa) |
| | ACC80947.1 | PFAM: inositol monophosphatase; KEGG: ana:alr4682 ammonium transporter protein 1. (286 aa) |
| | purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; KEGG: ava:Ava_3227 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (427 aa) |
| | ACC81081.1 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: ana:all0066 dCTP deaminase. (199 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa) |
| | ACC81411.1 | PFAM: diacylglycerol kinase, catalytic region; KEGG: ava:Ava_1023 hypothetical protein. (294 aa) |
| | ACC81456.1 | Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; GAF domain protein; Tetratricopeptide TPR_2 repeat protein; SMART: PAS domain containing protein; KEGG: ava:Ava_0091 adenylate/guanylate cyclase. (858 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: ava:Ava_0093 phosphoribosylaminoimidazole-succinocarboxamide synthase. (245 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (292 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (176 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (272 aa) |
| | ACC81463.1 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (388 aa) |
| | ACC81618.1 | PFAM: dehydrogenase, E1 component; KEGG: sco:SCO1270 putative pyruvate dehydrogenase alpha subunit. (311 aa) |
| | ACC81619.1 | Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (343 aa) |
| | ACC81620.1 | PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; KEGG: sco:SCO1268 acyltransferase. (367 aa) |
| | ACC81623.1 | PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal domain; Hydroxymethylglutaryl-coenzyme A synthase C terminal domain protein; KEGG: yps:YPTB1475 putative hydroxymethylglutaryl-coenzyme A synthase. (408 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | ACC82079.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: aba:Acid345_0338 hypothetical protein. (196 aa) |
| | ACC82144.1 | KEGG: ana:alr4005 putative lipid-A-disaccharide synthase. (442 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa) |
| | ACC82233.1 | Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa) |
| | ACC82453.1 | KEGG: ava:Ava_2844 hypothetical protein. (684 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (364 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (237 aa) |
| | ACC82685.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: ava:Ava_4454 phospholipid/glycerol acyltransferase. (244 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (350 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (207 aa) |
| | ACC82876.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (558 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (253 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpG | H+-transporting two-sector ATPase, B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (143 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (190 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (506 aa) |
| | atpG-2 | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (315 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa) |
| | ACC83289.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (421 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (227 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (408 aa) |
| | ACC83489.1 | TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; KEGG: ava:Ava_2078 competence damage-inducible protein A; Belongs to the CinA family. (416 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: ava:Ava_1174 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (370 aa) |
| | ACC83578.1 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; KEGG: ana:all2091 nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (288 aa) |
| | ACC83697.1 | KEGG: ava:Ava_0151 hypothetical protein. (619 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa) |
| | pdhA | Dehydrogenase, E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa) |
| | ACC84010.1 | Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (471 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (199 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (572 aa) |
| | ACC84049.1 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: ava:Ava_1669 pyridoxamine 5'-phosphate oxidase-related, FMN-binding. (194 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | ACC84127.1 | KEGG: ana:alr3885 probable phosphoribosylaminoimidazole carboxylase catalytic subunit. (262 aa) |
| | ACC84262.1 | KEGG: ava:Ava_1299 hypothetical protein. (435 aa) |
| | ACC84264.1 | Conserved hypothetical protein; KEGG: ana:all4350 unknown protein. (421 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (307 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | ACC84337.1 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: ana:alr3339 dihydroorotase. (434 aa) |
| | ACC84347.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | ACC84542.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: ava:Ava_0359 hypothetical protein. (285 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (214 aa) |
| | ACC84686.1 | PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: ava:Ava_3176 dihydrolipoamide acetyltransferase. (433 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | ACC84800.1 | KEGG: ter:Tery_3277 hypothetical protein. (296 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (92 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa) |
| | ACC78953.1 | PFAM: metallophosphoesterase; KEGG: ava:Ava_2738 metallophosphoesterase. (284 aa) |
| | ACC78954.1 | PFAM: metallophosphoesterase; KEGG: ana:all0250 hypothetical protein. (276 aa) |
| | ACC79135.1 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: ter:Tery_4585 adenylate/guanylate cyclase. (616 aa) |
| | ACC79214.1 | SMART: phospholipid/glycerol acyltransferase; KEGG: ava:Ava_2310 phospholipid/glycerol acyltransferase. (460 aa) |
| | nadD-2 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (222 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (279 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (176 aa) |
| | ACC79437.1 | KEGG: ccr:CC2858 hypothetical protein. (238 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (540 aa) |
| | ACC79515.1 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: ava:Ava_4953 ThiamineS. (91 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: ava:Ava_4410 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (388 aa) |
| | ACC80029.1 | Adenylate/guanylate cyclase with Chase sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: ana:all1118 adenylate cyclase. (742 aa) |
| | ACC80180.1 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: ter:Tery_3999 adenylate/guanylate cyclase. (159 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: ava:Ava_2537 GTP cyclohydrolase I. (235 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | ACC80423.1 | KEGG: ava:Ava_3582 phosphoribosyltransferase. (172 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | ACC80736.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: nmu:Nmul_A1375 glyoxalase/bleomycin resistance protein/dioxygenase. (136 aa) |
| | ACC81069.1 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ana:alr3395 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa) |
| | ACC81083.1 | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (240 aa) |
| | ACC81104.1 | TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ava:Ava_1643 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (180 aa) |
| | ACC81198.1 | KEGG: syg:sync_0797 hypothetical protein. (307 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (402 aa) |
| | pyrE-2 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (477 aa) |
| | ACC81988.1 | Adenylate/guanylate cyclase with integral membrane sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: ter:Tery_3999 adenylate/guanylate cyclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (433 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (457 aa) |
| | ACC82176.1 | PFAM: diacylglycerol kinase, catalytic region; KEGG: ava:Ava_4772 methylglyoxal synthase. (323 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (198 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (243 aa) |
| | ACC82295.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: ana:all4871 hypothetical protein. (252 aa) |
| | ACC82323.1 | Molybdenum cofactor synthesis domain protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (168 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (183 aa) |
| | ACC82361.1 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: ava:Ava_5046 hypothetical protein. (70 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (351 aa) |
| | thiG | Glycine oxidase ThiO; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (674 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa) |
| | ACC82457.1 | PFAM: molybdopterin biosynthesis MoaE; KEGG: ava:Ava_4754 molybdopterin biosynthesis MoaE. (162 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa) |
