STRINGSTRING
tdh tdh kbl kbl lpdA lpdA sdaA-1 sdaA-1 hprA hprA thrA thrA thrB thrB thrC thrC ltaA ltaA betA betA betB betB serC serC pssA pssA sdaA-2 sdaA-2 trpB trpB trpA trpA asd asd glxK glxK glyA glyA serB serB SVI_3421 SVI_3421 gcvP gcvP gcvH gcvH gcvT gcvT lysC lysC serA serA metL metL SVI_3863 SVI_3863 ilvA ilvA gpmA gpmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tdhThreonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
lpdAPyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. (476 aa)
sdaA-1L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
hprAGlycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa)
thrAAspartokinase I/homoserine dehydrogenase, threonine-sensitive; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
thrCThreonine synthase. (426 aa)
ltaAL-allo-threonine aldolase. (336 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (566 aa)
betBBetaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (364 aa)
pssACDP-diacylglycerol--serine O-phosphatidyltransferase. (439 aa)
sdaA-2L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (408 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
glxKGlycerate kinase; Belongs to the glycerate kinase type-1 family. (392 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
serBPhosphoserine phosphatase. (295 aa)
SVI_3421CDP-diacylglycerol--serine O-phosphatidyltransferase, putative; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (257 aa)
gcvPGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (966 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
lysCAspartokinase III, lysine-sensitive; Belongs to the aspartokinase family. (458 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
metLAspartokinase II/homoserine dehydrogenase, methionine-sensitive; In the C-terminal section; belongs to the homoserine dehydrogenase family. (795 aa)
SVI_3863Aminotransferase, class V. (380 aa)
ilvAThreonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
gpmAPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
Your Current Organism:
Shewanella violacea
NCBI taxonomy Id: 637905
Other names: S. violacea DSS12, Shewanella violacea DSS12, Shewanella violacea JCM 10179, Shewanella violacea str. DSS12, Shewanella violacea strain DSS12
Server load: low (22%) [HD]