STRINGSTRING
larC larC ybbP ybbP EEW38266.1 EEW38266.1 oadA oadA accB accB oadB oadB EEW38203.1 EEW38203.1 deoC deoC EEW38120.1 EEW38120.1 EEW38149.1 EEW38149.1 pabC pabC sdaAB sdaAB xfp xfp gloA gloA psuG psuG fabZ fabZ sdaAA sdaAA pflA pflA pyrF pyrF purB purB nth nth uxuA uxuA eda eda eda-2 eda-2 EEW37788.1 EEW37788.1 EEW37614.1 EEW37614.1 EEW37618.1 EEW37618.1 fba fba rhaD rhaD EEW37629.1 EEW37629.1 EEW37487.1 EEW37487.1 coaBC coaBC ebsC ebsC fucA fucA thrC thrC eno eno rhaD2 rhaD2 fba-2 fba-2 EEW37139.1 EEW37139.1 murQ murQ murQ-2 murQ-2 oadA2 oadA2 citF citF citE citE citC citC oadB2 oadB2 lacD lacD accB3 accB3 mvaD mvaD luxS luxS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
larCTIGR00299 family protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (467 aa)
ybbPTIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (281 aa)
EEW38266.1Hypothetical protein; 4.1.1.49. (549 aa)
oadAHMGL-like protein; COG: COG5016; Pfam: PF00682,PF02436; InterPro: IPR013785. (439 aa)
accBBiotin-requiring enzyme; COG: COG0511; Pfam: PF00364; InterPro: IPR000089. (122 aa)
oadBSodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (375 aa)
EEW38203.1Hypothetical protein; COG: COG4716; Pfam: PF06100; InterPro: IPR010354. (590 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
EEW38120.1Hypothetical protein; Pfam: PF02618. (163 aa)
EEW38149.1VanZ-like protein; Pfam: PF04892. (160 aa)
pabCYceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (380 aa)
sdaABL-serine dehydratase, iron-sulfur-dependent, beta subunit; COG: COG1760; Pfam: PF03315; InterPro: IPR004643; Belongs to the iron-sulfur dependent L-serine dehydratase family. (225 aa)
xfpD-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; COG: COG3957; Pfam: PF03894; InterPro: IPR005593. (789 aa)
gloAGlyoxalase family protein; COG: COG0346; Pfam: PF00903; InterPro: IPR004360. (125 aa)
psuGTat pathway signal sequence domain protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (304 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa)
sdaAAL-serine dehydratase, iron-sulfur-dependent, alpha subunit; COG: COG1760; Pfam: PF03313; InterPro: IPR004642; Belongs to the iron-sulfur dependent L-serine dehydratase family. (300 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (254 aa)
pyrFOrotidine 5'-phosphate decarboxylase/HUMPS family; COG: COG0269; Pfam: PF00215; InterPro: IPR013785. (212 aa)
purBAdenylosuccinate lyase; COG: COG0015; Pfam: PF00206; InterPro: IPR004769; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (422 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
uxuAMannonate dehydratase; Catalyzes the dehydration of D-mannonate. (350 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; COG: COG0800; Pfam: PF01081; InterPro: IPR013785. (209 aa)
eda-22-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; COG: COG0800; Pfam: PF01081; InterPro: IPR013785. (223 aa)
EEW37788.1Heparinase II/III-like protein; Pfam: PF07940. (619 aa)
EEW37614.1LPXTG-motif cell wall anchor domain protein; Pfam: PF02018,PF08124,PF02278,PF02884,PF00746; InterPro: IPR012329. (1106 aa)
EEW37618.1Putative secondary thiamine-phosphate synthase enzyme; Pfam: PF01894; InterPro: IPR001602. (173 aa)
fbaKetose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR000771. (274 aa)
rhaDPutative rhamnulose-1-phosphate aldolase; COG: COG0235; Pfam: PF00596; InterPro: IPR001303. (262 aa)
EEW37629.1Fructose-bisphosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. (293 aa)
EEW37487.1Polysaccharide biosynthesis protein; COG: COG1086; Pfam: PF02719; InterPro: IPR003869. (601 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa)
ebsCYbaK/EbsC protein; COG: COG2606; Pfam: PF04073; InterPro: IPR004369; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (167 aa)
fucAPutative L-ribulose-5-phosphate 4-epimerase; COG: COG0235; Pfam: PF00596; InterPro: IPR001303. (240 aa)
thrCThreonine synthase; COG: COG0498; Pfam: PF00291; InterPro: IPR004450. (481 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
rhaD2Putative rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (293 aa)
fba-2Fructose-1,6-bisphosphate aldolase, class II; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. (279 aa)
EEW37139.1ATP-grasp domain protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (381 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (301 aa)
murQ-2N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa)
oadA2HMGL-like protein; COG: COG5016; Pfam: PF00682,PF02436; InterPro: IPR000891. (464 aa)
citFCitrate lyase, alpha subunit; COG: COG3051; Pfam: PF04223; InterPro: IPR006472. (510 aa)
citECitrate (pro-3S)-lyase, beta subunit; COG: COG2301; Pfam: PF03328; InterPro: IPR006475; Belongs to the HpcH/HpaI aldolase family. (295 aa)
citC[citrate (pro-3S)-lyase] ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (336 aa)
oadB2Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (373 aa)
lacDTagatose-bisphosphate aldolase; COG: COG3684; Pfam: PF01791; InterPro: IPR005927; Belongs to the aldolase LacD family. (334 aa)
accB3Biotin-requiring enzyme; Pfam: PF00364; InterPro: IPR000089. (129 aa)
mvaDDiphosphomevalonate decarboxylase; COG: COG3407; Pfam: PF00288,PF08544; InterPro: IPR005935. (340 aa)
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (187 aa)
Your Current Organism:
Granulicatella adiacens
NCBI taxonomy Id: 638301
Other names: G. adiacens ATCC 49175, Granulicatella adiacens ATCC 49175, Granulicatella adiacens str. ATCC 49175, Granulicatella adiacens strain ATCC 49175
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