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| | trpS | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (331 aa) |
| | glcK | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. (302 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | Phosphoglycerate kinase; COG: COG0126; Pfam: PF00162; InterPro: IPR001576; Belongs to the phosphoglycerate kinase family. (423 aa) |
| | ilvE | Branched-chain-amino-acid transaminase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. (341 aa) |
| | EEW36853.1 | Hypothetical protein; Pfam: PF02588. (202 aa) |
| | hipO | Amidohydrolase; COG: COG1473; Pfam: PF01546,PF07687; InterPro: IPR010168. (382 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (335 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (359 aa) |
| | acpP-2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (95 aa) |
| | ansA | L-asparaginase, type II; COG: COG0252; Pfam: PF00710; InterPro: IPR006034. (329 aa) |
| | atoB | acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (235 aa) |
| | panE2 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (315 aa) |
| | fba-2 | Fructose-1,6-bisphosphate aldolase, class II; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. (279 aa) |
| | EEW37017.1 | Amidohydrolase; COG: COG1473; Pfam: PF01546,PF07687; InterPro: IPR010168. (388 aa) |
| | lysS | lysine--tRNA ligase; COG: COG1190; Pfam: PF01336,PF00152; InterPro: IPR002313; Belongs to the class-II aminoacyl-tRNA synthetase family. (501 aa) |
| | EEW37056.1 | Acetyltransferase, GNAT family; Pfam: PF00583. (156 aa) |
| | metG | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (670 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (301 aa) |
| | anmK | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (380 aa) |
| | murQ-2 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa) |
| | cysS-2 | cysteine--tRNA ligase; COG: COG0215; Pfam: PF01406,PF09190; InterPro: IPR002308; overlaps another CDS with the same product name; Belongs to the class-I aminoacyl-tRNA synthetase family. (469 aa) |
| | cysE | Serine O-acetyltransferase; COG: COG1045; Pfam: PF00132; InterPro: IPR005881. (186 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (102 aa) |
| | accB3 | Biotin-requiring enzyme; Pfam: PF00364; InterPro: IPR000089. (129 aa) |
| | gltX | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (499 aa) |
| | EEW36706.1 | acyl-CoA dehydrogenase, C-terminal domain protein; Pfam: PF08028. (378 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | EEW36742.1 | ASCH domain protein; Pfam: PF07060; InterPro: IPR010759. (114 aa) |
| | metE | Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717. (379 aa) |
| | EEW36826.1 | Putative cyclase; COG: COG1878; Pfam: PF04199; InterPro: IPR007325. (250 aa) |
| | metE2 | Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. (399 aa) |
| | metE3 | Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. (378 aa) |
| | glnA | Glutamine synthetase, type I; COG: COG0174; Pfam: PF03951,PF00120; InterPro: IPR004809. (443 aa) |
| | cysK | Cysteine synthase A; COG: COG0031; Pfam: PF00291; InterPro: IPR005859; Belongs to the cysteine synthase/cystathionine beta- synthase family. (313 aa) |
| | ldhA2 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (324 aa) |
| | mtnN-2 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (308 aa) |
| | EEW36361.1 | Hypothetical protein. (49 aa) |
| | glmS | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa) |
| | EEW36411.1 | Flavoprotein family protein; COG: COG2081; Pfam: PF03486; InterPro: IPR004792. (426 aa) |
| | serS | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | EEW36434.1 | Thioesterase family protein; COG: COG1607; Pfam: PF03061; InterPro: IPR006683. (177 aa) |
| | tyrA | Chorismate mutase; Pfam: PF01817; InterPro: IPR011279. (88 aa) |
| | tyrS | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (421 aa) |
| | cobQ | CobB/CobQ-like protein; COG: COG3442; Pfam: PF07685; InterPro: IPR011698. (219 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | accB | Biotin-requiring enzyme; COG: COG0511; Pfam: PF00364; InterPro: IPR000089. (122 aa) |
| | proS | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (482 aa) |
| | EEW38203.1 | Hypothetical protein; COG: COG4716; Pfam: PF06100; InterPro: IPR010354. (590 aa) |
| | ileS | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (929 aa) |
| | glk | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR004654. (322 aa) |
| | alaS | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (914 aa) |
| | nanE | Putative N-acetylmannosamine-6-phosphate epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (225 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa) |
| | gpm | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (254 aa) |
| | EEW37970.1 | Aspartate kinase; COG: COG0527; Pfam: PF00696,PF01842; InterPro: IPR001341; Belongs to the aspartokinase family. (458 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (169 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (368 aa) |
| | pdhB | Transketolase, pyridine binding domain protein; COG: COG0022; Pfam: PF02779,PF02780; InterPro: IPR005475. (325 aa) |
| | aceF | Putative dihydrolipoyllysine-residue acetyltransferase; COG: COG0508; Pfam: PF00364,PF02817,PF00198; InterPro: IPR001078. (538 aa) |
| | EEW38029.1 | Amidohydrolase family protein; COG: COG1574; Pfam: PF07969; InterPro: IPR013108. (528 aa) |
| | fabHA | Beta-ketoacyl-acyl-carrier-protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (316 aa) |
| | acpP | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (76 aa) |
| | fabD | [acyl-carrier-protein] S-malonyltransferase; COG: COG0331; Pfam: PF00698; InterPro: IPR004410. (343 aa) |
| | fabF | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa) |
| | accB-2 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (461 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (286 aa) |
| | accA | Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (255 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | hisS | histidine--tRNA ligase; COG: COG0124; Pfam: PF00587,PF03129; InterPro: IPR015805. (438 aa) |
| | aspS | aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (587 aa) |
| | EEW37885.1 | Hypothetical protein; COG: COG2220; 3.1.1.-. (353 aa) |
| | EEW37895.1 | Hypothetical protein. (208 aa) |
| | EEW37696.1 | Acyl-ACP thioesterase; COG: COG3884; Pfam: PF01643; InterPro: IPR002864. (240 aa) |
| | glyS | glycine--tRNA ligase, beta subunit; COG: COG0751; Pfam: PF02092,PF05746; InterPro: IPR015944. (689 aa) |
| | glyQ | glycine--tRNA ligase, alpha subunit; COG: COG0752; Pfam: PF02091; InterPro: IPR002310. (294 aa) |
| | iscS2 | Aminotransferase, class V; COG: COG1104; Pfam: PF00266; InterPro: IPR000192. (374 aa) |
| | leuS | leucine--tRNA ligase; COG: COG0495; Pfam: PF00133,PF08264; InterPro: IPR002302; Belongs to the class-I aminoacyl-tRNA synthetase family. (818 aa) |
| | asnS | asparagine--tRNA ligase; COG: COG0017; Pfam: PF01336,PF00152; InterPro: IPR004522. (433 aa) |
| | pyk | Pyruvate kinase; COG: COG0469; Pfam: PF00224,PF02887; InterPro: IPR001697; Belongs to the pyruvate kinase family. (472 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (350 aa) |
| | uxaC | Glucuronate isomerase; COG: COG1904; Pfam: PF02614; InterPro: IPR003766. (467 aa) |
| | EEW37619.1 | Putative triose-phosphate isomerase; COG: COG0149; Pfam: PF00121; InterPro: IPR013785. (229 aa) |
| | fba | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR000771. (274 aa) |
| | EEW37629.1 | Fructose-bisphosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. (293 aa) |
| | dapB | Putative dihydrodipicolinate reductase domain protein; Pfam: PF01113. (351 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (298 aa) |
| | hom | Homoserine dehydrogenase; COG: COG0460; Pfam: PF03447,PF00742; InterPro: IPR001342. (415 aa) |
| | EEW37368.1 | tRNA binding domain protein; COG: COG0073; Pfam: PF01588; InterPro: IPR012340; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (208 aa) |
| | sufS | Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (410 aa) |
| | EEW37408.1 | Peptidase C26; COG: COG2071; Pfam: PF07722; InterPro: IPR011697. (248 aa) |
| | gcvH | Glycine cleavage H-protein; COG: COG0509; Pfam: PF01597; InterPro: IPR002930. (129 aa) |
| | pheT | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (806 aa) |
| | pheS | phenylalanine--tRNA ligase, alpha subunit; COG: COG0016; Pfam: PF02912,PF01409; InterPro: IPR002319; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (351 aa) |
| | gnd | Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (477 aa) |
| | thrS | threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (647 aa) |
| | pgi | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. (448 aa) |
| | gcvH2 | Glycine cleavage H-protein; COG: COG0509; Pfam: PF01597; InterPro: IPR002930. (120 aa) |
| | EEW37555.1 | Hypothetical protein. (76 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (371 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (129 aa) |
| | mdsC | Phosphotransferase enzyme family; Pfam: PF01636. (371 aa) |
| | valS | valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (880 aa) |
| | thrC | Threonine synthase; COG: COG0498; Pfam: PF00291; InterPro: IPR004450. (481 aa) |
| | argS | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. (563 aa) |
