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Snov_0115 Snov_0115 hisD hisD Snov_0173 Snov_0173 hisD-2 hisD-2 Snov_0250 Snov_0250 Snov_0326 Snov_0326 Snov_0327 Snov_0327 ilvC ilvC glyA glyA Snov_0495 Snov_0495 Snov_0571 Snov_0571 Snov_0592 Snov_0592 Snov_0653 Snov_0653 Snov_0906 Snov_0906 Snov_1022 Snov_1022 Snov_1077 Snov_1077 Snov_1089 Snov_1089 aroQ aroQ Snov_1527 Snov_1527 Snov_1529 Snov_1529 Snov_1599 Snov_1599 Snov_1600 Snov_1600 Snov_1601 Snov_1601 Snov_1602 Snov_1602 Snov_1606 Snov_1606 Snov_1644 Snov_1644 Snov_1660 Snov_1660 Snov_1778 Snov_1778 trpE trpE Snov_1815 Snov_1815 trpD trpD trpC trpC Snov_1919 Snov_1919 hisI hisI Snov_2113 Snov_2113 Snov_2281 Snov_2281 Snov_2282 Snov_2282 Snov_2283 Snov_2283 leuA leuA Snov_2367 Snov_2367 ilvE ilvE Snov_2530 Snov_2530 Snov_2636 Snov_2636 Snov_2637 Snov_2637 Snov_2638 Snov_2638 Snov_2639 Snov_2639 Snov_2640 Snov_2640 Snov_2641 Snov_2641 Snov_2708 Snov_2708 leuB leuB leuD leuD leuC leuC aroK aroK aroB aroB hisD-3 hisD-3 Snov_2965 Snov_2965 Snov_3002 Snov_3002 Snov_3003 Snov_3003 Snov_3004 Snov_3004 Snov_3011 Snov_3011 Snov_3118 Snov_3118 Snov_3289 Snov_3289 Snov_3470 Snov_3470 hisC hisC metXA metXA Snov_3474 Snov_3474 Snov_3710 Snov_3710 aroE aroE Snov_3823 Snov_3823 Snov_3825 Snov_3825 hisB hisB Snov_3827 Snov_3827 hisH hisH hisA hisA hisF hisF hisE hisE Snov_3834 Snov_3834 Snov_3835 Snov_3835 aroA aroA trpA trpA trpB trpB trpF trpF Snov_4067 Snov_4067 katG katG Snov_4324 Snov_4324 aroC aroC Snov_4458 Snov_4458 hisG hisG
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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Snov_0115KEGG: atc:AGR_L_3190 putative dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (601 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
Snov_0173PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: mrd:Mrad2831_4405 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (329 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa)
Snov_0250KEGG: azc:AZC_0138 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (282 aa)
Snov_0326KEGG: azc:AZC_2376 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (586 aa)
Snov_0327KEGG: xau:Xaut_1489 acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (171 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
Snov_0495KEGG: bxe:Bxe_B1348 D-amino acid dehydrogenase small subunit; PFAM: FAD dependent oxidoreductase. (431 aa)
Snov_0571PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; KEGG: mrd:Mrad2831_2117 thiamine pyrophosphate protein; Belongs to the TPP enzyme family. (563 aa)
Snov_0592TIGRFAM: threonine synthase; KEGG: azc:AZC_2239 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (469 aa)
Snov_0653PFAM: aminotransferase class IV; KEGG: mno:Mnod_1805 aminotransferase class IV. (286 aa)
Snov_0906TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: bja:blr3778 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II. (461 aa)
Snov_1022KEGG: rso:RSp0329 3-isopropylmalate dehydrogenase oxidoreductase protein; PFAM: isocitrate/isopropylmalate dehydrogenase. (363 aa)
Snov_1077Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa)
Snov_1089PFAM: YicC domain protein; domain of unknown function DUF1732; KEGG: azc:AZC_4317 hypothetical protein. (295 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
Snov_1527PFAM: Chorismate mutase, type II; KEGG: azc:AZC_2845 chorismate mutase family protein. (97 aa)
Snov_1529PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: rpd:RPD_2099 hypothetical protein. (318 aa)
Snov_1599Membrane protein AbrB duplication; KEGG: reh:H16_A3721 putative ammonia monooxygenase; TIGRFAM: membrane protein AbrB duplication; PFAM: putative ammonia monooxygenase. (368 aa)
Snov_1600PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bbe:BBR47_25270 hypothetical protein. (264 aa)
Snov_1601KEGG: acr:Acry_1270 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
Snov_1602TIGRFAM: tartrate dehydrogenase; KEGG: mno:Mnod_1445 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (368 aa)
Snov_1606TIGRFAM: tartrate dehydrogenase; KEGG: reu:Reut_C5899 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (361 aa)
Snov_1644KEGG: xau:Xaut_4294 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (408 aa)
Snov_1660KEGG: rpb:RPB_3648 D-amino-acid dehydrogenase; PFAM: FAD dependent oxidoreductase. (413 aa)
Snov_1778PFAM: aminotransferase class IV; KEGG: xau:Xaut_4394 aminotransferase class IV. (286 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa)
Snov_1815KEGG: xau:Xaut_4377 glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (202 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa)
trpCKEGG: azc:AZC_2205 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa)
Snov_1919KEGG: met:M446_1318 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (573 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (161 aa)
Snov_2113PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: xau:Xaut_4110 pyridoxal-5'-phosphate-dependent protein beta subunit. (329 aa)
Snov_2281TIGRFAM: para-aminobenzoate synthase, subunit I; KEGG: mno:Mnod_0053 para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein. (474 aa)
Snov_2282KEGG: met:M446_0052 glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (194 aa)
Snov_2283PFAM: aminotransferase class IV; KEGG: mea:Mex_1p4282 putative branched-chain amino acid aminotransferase. (256 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
Snov_2367PFAM: aminotransferase class I and II; KEGG: xau:Xaut_2737 aminotransferase class I and II. (400 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa)
Snov_2530PFAM: aminotransferase class V; KEGG: rme:Rmet_5630 aminotransferase, class V. (401 aa)
Snov_2636KEGG: pde:Pden_3918 ornithine cyclodeaminase; PFAM: ornithine cyclodeaminase/mu-crystallin. (320 aa)
Snov_2637PFAM: alanine racemase domain protein; KEGG: pde:Pden_3919 alanine racemase domain-containing protein. (391 aa)
Snov_2638PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: mes:Meso_3309 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (316 aa)
Snov_2639PFAM: 6-phosphogluconate dehydrogenase NAD-binding; KEGG: azc:AZC_3490 2-hydroxy-3-oxopropionate reductase. (54 aa)
Snov_2640PFAM: extracellular solute-binding protein family 3; KEGG: rso:RS04698 periplasmic substrate binding ABC transporter protein. (198 aa)
Snov_2641PFAM: integrase family protein; KEGG: mno:Mnod_7637 integrase family protein; Belongs to the 'phage' integrase family. (458 aa)
Snov_2708KEGG: xau:Xaut_2818 histidinol-phosphate phosphatase, putative; TIGRFAM: histidinol-phosphate phosphatase; PFAM: inositol monophosphatase. (261 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (369 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (201 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (386 aa)
hisD-3Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
Snov_2965PFAM: aminotransferase class I and II; KEGG: azc:AZC_0558 aspartate aminotransferase. (401 aa)
Snov_3002PFAM: Domain of unknown function DUF1902; KEGG: tgr:Tgr7_1809 domain of unknown function DUF1902. (75 aa)
Snov_3003TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: xau:Xaut_1202 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (528 aa)
Snov_3004Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (391 aa)
Snov_3011TIGRFAM: L-serine dehydratase 1; KEGG: msl:Msil_1803 L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
Snov_3118TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: bra:BRADO5568 phosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) (PSPase); PFAM: Haloacid dehalogenase domain protein hydrolase. (297 aa)
Snov_3289KEGG: rpb:RPB_0869 phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; Belongs to the PRA-PH family. (139 aa)
Snov_3470KEGG: xau:Xaut_0393 arogenate dehydrogenase; PFAM: Prephenate dehydrogenase. (311 aa)
hisCKEGG: xau:Xaut_0394 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (396 aa)
Snov_3474KEGG: azc:AZC_0228 methionine biosynthesis MetW protein; TIGRFAM: methionine biosynthesis protein MetW; PFAM: Methionine biosynthesis MetW protein. (227 aa)
Snov_3710Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (350 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa)
Snov_3823PFAM: GCN5-related N-acetyltransferase; KEGG: mlo:mll5006 aminoglycoside 6'-N-acetyltransferase. (171 aa)
Snov_3825PFAM: major facilitator superfamily MFS_1; KEGG: bac:BamMC406_6240 major facilitator transporter. (409 aa)
hisBKEGG: azc:AZC_4502 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (197 aa)
Snov_3827PFAM: Protein of unknown function DUF2506; KEGG: azc:AZC_4501 hypothetical protein. (162 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (220 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: xau:Xaut_2290 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (247 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa)
hisEKEGG: azc:AZC_4497 phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase. (112 aa)
Snov_3834PFAM: 2OG-Fe(II) oxygenase; KEGG: azc:AZC_4284 alkylated DNA repair protein. (214 aa)
Snov_3835KEGG: xau:Xaut_0345 hypothetical protein. (315 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (453 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa)
trpFKEGG: rpb:RPB_0636 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (236 aa)
Snov_4067KEGG: bja:bll6321 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
katGCatalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (756 aa)
Snov_4324KEGG: pol:Bpro_5111 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa)
Snov_4458PFAM: tRNA synthetase class II (G H P and S); KEGG: xau:Xaut_4746 ATP phosphoribosyltransferase regulatory subunit. (372 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (323 aa)
Your Current Organism:
Starkeya novella
NCBI taxonomy Id: 639283
Other names: S. novella DSM 506, Starkeya novella DSM 506, Starkeya novella IAM 12100, Starkeya novella str. DSM 506, Starkeya novella strain DSM 506
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