STRINGSTRING
Snov_0065 Snov_0065 Snov_0099 Snov_0099 Snov_0100 Snov_0100 Snov_0172 Snov_0172 Snov_0294 Snov_0294 Snov_0295 Snov_0295 Snov_0296 Snov_0296 dut dut Snov_0298 Snov_0298 folD folD mutM mutM Snov_0656 Snov_0656 Snov_0657 Snov_0657 Snov_0744 Snov_0744 guaB guaB guaA guaA Snov_0964 Snov_0964 panB panB purF purF Snov_1075 Snov_1075 gmk gmk purN purN purM purM Snov_1413 Snov_1413 panC panC pyrC pyrC pyrB pyrB Snov_1612 Snov_1612 pyrE pyrE glyA-2 glyA-2 nrdR nrdR Snov_1654 Snov_1654 Snov_1655 Snov_1655 ribH ribH nusB nusB thiL thiL coaD coaD surE surE Snov_1994 Snov_1994 folE folE fhs fhs gpt gpt Snov_2143 Snov_2143 purC purC purS purS purQ purQ purL purL carA carA carB carB purH purH Snov_2986 Snov_2986 purA purA Snov_3092 Snov_3092 thyA thyA purE purE purK purK Snov_3348 Snov_3348 Snov_3392 Snov_3392 Snov_3407 Snov_3407 Snov_3738 Snov_3738 coaE coaE coaA coaA Snov_3877 Snov_3877 purD purD Snov_3922 Snov_3922 pyrF pyrF Snov_4180 Snov_4180 Snov_4181 Snov_4181 Snov_4266 Snov_4266 ribB ribB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Snov_0065Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa)
Snov_0099PFAM: GTP cyclohydrolase II; KEGG: reh:H16_B1597 hypothetical protein. (422 aa)
Snov_0100PFAM: protein of unknown function DUF1688; KEGG: bja:blr7238 hypothetical protein. (409 aa)
Snov_0172TIGRFAM: amidase, hydantoinase/carbamoylase family; KEGG: mrd:Mrad2831_5813 allantoate amidohydrolase; PFAM: peptidase M20. (417 aa)
Snov_0294Hypothetical protein. (42 aa)
Snov_0295KEGG: lxx:Lxx08160 transmembrane efflux pump. (39 aa)
Snov_0296Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (409 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa)
Snov_0298KEGG: xau:Xaut_0076 BadM/Rrf2 family transcriptional regulator; TIGRFAM: transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074. (147 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (299 aa)
Snov_0656Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa)
Snov_0657TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; KEGG: xau:Xaut_2492 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (183 aa)
Snov_0744Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (496 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (533 aa)
Snov_0964PFAM: CBS domain containing protein; KEGG: pis:Pisl_0269 signal transduction protein. (131 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (499 aa)
Snov_1075PFAM: Colicin V production protein; KEGG: oca:OCAR_6381 CvpA family protein. (199 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (220 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: azc:AZC_4161 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (359 aa)
Snov_1413PFAM: CutA1 divalent ion tolerance protein; KEGG: azc:AZC_0954 CutA protein. (110 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (286 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; KEGG: azc:AZC_2851 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa)
Snov_1612KEGG: gbr:Gbro_4379 protein of unknown function DUF201. (299 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (197 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
nrdRATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (172 aa)
Snov_1654Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa)
Snov_1655TIGRFAM: riboflavin synthase, alpha subunit; KEGG: xau:Xaut_4279 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (196 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (164 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (160 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (331 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
Snov_1994PFAM: Xanthine/uracil/vitamin C permease; KEGG: azc:AZC_0139 putative xanthine/uracil permease. (567 aa)
folETIGRFAM: GTP cyclohydrolase I; KEGG: azc:AZC_0942 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (212 aa)
fhsKEGG: xau:Xaut_1383 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. (564 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (168 aa)
Snov_2143KEGG: nwi:Nwi_2167 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: azc:AZC_2228 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (269 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (232 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa)
carAKEGG: xau:Xaut_1243 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (400 aa)
carBKEGG: azc:AZC_1145 carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1111 aa)
purHSMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: xau:Xaut_1732 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (529 aa)
Snov_29862-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (325 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
Snov_3092Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (169 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
Snov_3348PFAM: peptidase M50; CBS domain containing protein; KEGG: xau:Xaut_1988 peptidase M50; Belongs to the peptidase M50B family. (370 aa)
Snov_3392PFAM: glutamine amidotransferase class-I; KEGG: mno:Mnod_0664 glutamine amidotransferase class-I. (249 aa)
Snov_3407TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: azc:AZC_4610 hypoxanthine phosphoribosyl transferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (201 aa)
Snov_3738PFAM: bifunctional deaminase-reductase domain protein; KEGG: met:M446_2359 deaminase-reductase domain-containing protein. (241 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa)
coaATIGRFAM: pantothenate kinase; KEGG: azc:AZC_4496 pantothenate kinase. (320 aa)
Snov_3877KEGG: xau:Xaut_1415 dihydroorotase; TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. (457 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; KEGG: xau:Xaut_1412 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (425 aa)
Snov_3922TIGRFAM: FolC bifunctional protein; KEGG: azc:AZC_1025 folylpolyglutamate synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein. (447 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (242 aa)
Snov_4180Dihydropyrimidinase; KEGG: mes:Meso_2664 phenylhydantoinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (485 aa)
Snov_4181TIGRFAM: amidase, hydantoinase/carbamoylase family; KEGG: sil:SPO1781 allantoate amidohydrolase; PFAM: peptidase M20. (415 aa)
Snov_4266Dihydropyrimidinase; KEGG: mno:Mnod_7926 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (475 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (434 aa)
Your Current Organism:
Starkeya novella
NCBI taxonomy Id: 639283
Other names: S. novella DSM 506, Starkeya novella DSM 506, Starkeya novella IAM 12100, Starkeya novella str. DSM 506, Starkeya novella strain DSM 506
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.