STRINGSTRING
mch mch glyA glyA folD folD purU purU Snov_0752 Snov_0752 Snov_0755 Snov_0755 Snov_0756 Snov_0756 ffsA ffsA Snov_0758 Snov_0758 Snov_1050 Snov_1050 glyA-2 glyA-2 folE folE fhs fhs Snov_2322 Snov_2322 Snov_3057 Snov_3057 Snov_3092 Snov_3092 Snov_3955 Snov_3955 ahcY ahcY
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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Your Input:
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (322 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
Snov_0752PFAM: Methylene-tetrahydromethanopterin dehydrogenase; KEGG: xau:Xaut_1787 methylene-tetrahydromethanopterin dehydrogenase. (298 aa)
Snov_0755KEGG: xau:Xaut_1796 formylmethanofuran dehydrogenase. (413 aa)
Snov_0756KEGG: xau:Xaut_1795 amidohydrolase 3; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3. (555 aa)
ffsAFormylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (304 aa)
Snov_0758KEGG: xau:Xaut_1793 glutamate synthase alpha subunit; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein. (266 aa)
Snov_1050KEGG: xau:Xaut_0032 formaldehyde-activating protein; TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae). (168 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
folETIGRFAM: GTP cyclohydrolase I; KEGG: azc:AZC_0942 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (212 aa)
fhsKEGG: xau:Xaut_1383 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. (564 aa)
Snov_2322TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: azc:AZC_4340 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (308 aa)
Snov_3057KEGG: azc:AZC_0508 antifreeze protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (201 aa)
Snov_3092Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (169 aa)
Snov_3955TIGRFAM: S-adenosylmethionine synthetase; KEGG: xau:Xaut_1816 methionine adenosyltransferase; PFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (397 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (468 aa)
Your Current Organism:
Starkeya novella
NCBI taxonomy Id: 639283
Other names: S. novella DSM 506, Starkeya novella DSM 506, Starkeya novella IAM 12100, Starkeya novella str. DSM 506, Starkeya novella strain DSM 506
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