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gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (918 aa) | ||||
Snov_3217 | PFAM: polysaccharide biosynthesis protein CapD; KEGG: swp:swp_1595 polysaccharide biosynthesis protein CapD. (664 aa) | ||||
Snov_3210 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: kse:Ksed_18630 nucleoside-diphosphate-sugar epimerase. (379 aa) | ||||
Snov_3209 | TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; KEGG: kse:Ksed_18640 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (377 aa) | ||||
Snov_3198 | KEGG: rsk:RSKD131_3687 proline racemase; PFAM: proline racemase; Belongs to the proline racemase family. (337 aa) | ||||
truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (250 aa) | ||||
truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (326 aa) | ||||
Snov_3211 | UDP-glucose 4-epimerase; KEGG: pfl:PFL_5106 polysaccharide biosynthesis protein; PFAM: polysaccharide biosynthesis protein CapD; Polysaccharide biosynthesis domain protein. (341 aa) | ||||
Snov_3918 | RNA-binding S4 domain protein; KEGG: azc:AZC_2390 pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; SMART: RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family. (764 aa) | ||||
trpF | KEGG: rpb:RPB_0636 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (236 aa) | ||||
Snov_4078 | PFAM: Asp/Glu/hydantoin racemase; KEGG: rhi:NGR_b06480 hypothetical protein. (229 aa) | ||||
Snov_4095 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rsk:RSKD131_4204 short chain enoyl-CoA hydratase. (264 aa) | ||||
Snov_4124 | KEGG: azc:AZC_2284 topoisomerase IB. (374 aa) | ||||
Snov_4154 | PFAM: Asp/Glu/hydantoin racemase; KEGG: mlo:mlr7137 arylmalonate decarboxylase. (261 aa) | ||||
Snov_4205 | PFAM: amino acid permease-associated region; KEGG: afw:Anae109_4244 amino acid permease-associated region. (460 aa) | ||||
kduI | 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family. (280 aa) | ||||
Snov_3334 | KEGG: gau:GAU_3222 isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: Chorismate binding-like. (402 aa) | ||||
dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa) | ||||
pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (227 aa) | ||||
Snov_3472 | PFAM: Chorismate mutase, type II; KEGG: xau:Xaut_0395 hypothetical protein. (304 aa) | ||||
Snov_3500 | PFAM: Protein of unknown function DUF2088; KEGG: cai:Caci_4917 hypothetical protein. (435 aa) | ||||
Snov_3560 | PFAM: Xylose isomerase domain protein TIM barrel; AP endonuclease 2 domain protein; KEGG: rhi:NGR_c29470 putative endonuclease. (352 aa) | ||||
Snov_4206 | KEGG: pmy:Pmen_1109 arginine/ornithine antiporter; TIGRFAM: arginine/ornithine antiporter; PFAM: amino acid permease-associated region. (498 aa) | ||||
Snov_3145 | PFAM: amino acid permease-associated region; KEGG: xau:Xaut_4032 amino acid permease-associated region. (505 aa) | ||||
purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) | ||||
glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa) | ||||
Snov_2984 | TIGRFAM: hydroxypyruvate isomerase; KEGG: oca:OCAR_6561 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (261 aa) | ||||
Snov_2932 | PFAM: 4-oxalocrotonate tautomerase; KEGG: mno:Mnod_0818 4-oxalocrotonate tautomerase family enzyme. (77 aa) | ||||
groL-3 | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa) | ||||
Snov_2859 | PFAM: Asp/Glu/hydantoin racemase; KEGG: bph:Bphy_7794 Asp/Glu/hydantoin racemase. (245 aa) | ||||
Snov_2819 | PFAM: pseudouridine synthase; KEGG: azc:AZC_4596 pseudouridine synthase. (250 aa) | ||||
Snov_2789 | PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: xau:Xaut_3112 PpiC-type peptidyl-prolyl cis-trans isomerase. (337 aa) | ||||
Snov_2773 | PFAM: cobalamin B12-binding domain protein; KEGG: xau:Xaut_5018 cobalamin B12-binding domain-containing protein. (135 aa) | ||||
Snov_2770 | TIGRFAM: methylmalonyl-CoA mutase, large subunit; KEGG: xau:Xaut_5021 methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (568 aa) | ||||
Snov_2687 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (348 aa) | ||||
Snov_2569 | KEGG: xau:Xaut_3284 precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase CbiC/CobH. (211 aa) | ||||
xylA | TIGRFAM: xylose isomerase; KEGG: bra:BRADO2360 xylose isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the xylose isomerase family. (439 aa) | ||||
Snov_2537 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: azc:AZC_1808 enoyl-CoA hydratase. (267 aa) | ||||
Snov_2489 | TIGRFAM: conserved hypothetical protein; KEGG: azc:AZC_3511 double-transmembrane region. (966 aa) | ||||
Snov_2343 | PFAM: Aldose 1-epimerase; KEGG: xau:Xaut_3343 aldose 1-epimerase. (295 aa) | ||||
pgi | KEGG: bov:BOV_0299 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (547 aa) | ||||
Snov_2250 | PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: smd:Smed_2743 phosphoglucomutase. (542 aa) | ||||
nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (496 aa) | ||||
tig | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (450 aa) | ||||
murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (280 aa) | ||||
Snov_2141 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: bra:BRADO2842 ribulose-phosphate 3-epimerase (pentose-5-phosphate 3-epimerase) (PPE) (R5P3E); PFAM: ribulose-phosphate 3-epimerase. (228 aa) | ||||
groL-2 | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa) | ||||
Snov_1922 | KEGG: mrd:Mrad2831_3407 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (260 aa) | ||||
Snov_1918 | PFAM: Asp/Glu/hydantoin racemase; KEGG: mrd:Mrad2831_3408 Asp/Glu/hydantoin racemase. (220 aa) | ||||
Snov_1870 | TIGRFAM: KpsF/GutQ family protein; KEGG: mno:Mnod_1252 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. (338 aa) | ||||
Snov_1813 | KEGG: xau:Xaut_4379 PpiC-type peptidyl-prolyl cis-trans isomerase. (629 aa) | ||||
tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) | ||||
Snov_1764 | TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; KEGG: xau:Xaut_3550 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (482 aa) | ||||
Snov_1740 | KEGG: met:M446_3131 ribose-5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (148 aa) | ||||
queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (364 aa) | ||||
Snov_1683 | Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (152 aa) | ||||
Snov_1682 | Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (184 aa) | ||||
Snov_1647 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: azc:AZC_1544 putative enoyl-CoA hydratase. (370 aa) | ||||
parC | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (744 aa) | ||||
Snov_1527 | PFAM: Chorismate mutase, type II; KEGG: azc:AZC_2845 chorismate mutase family protein. (97 aa) | ||||
topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (879 aa) | ||||
Snov_1477 | TIGRFAM: pseudouridine synthase, RluA family; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; KEGG: xau:Xaut_4767 RluA family pseudouridine synthase; SMART: RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RluA family. (363 aa) | ||||
parE | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (680 aa) | ||||
Snov_1093 | PFAM: SurA domain; KEGG: azc:AZC_4322 hypothetical protein. (326 aa) | ||||
Snov_1077 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa) | ||||
Snov_1067 | PFAM: NnrUfamily protein; KEGG: azc:AZC_4332 hypothetical protein. (189 aa) | ||||
Snov_0933 | PFAM: aminotransferase class-III; KEGG: mlo:mll5149 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa) | ||||
rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa) | ||||
Snov_0747 | PFAM: histidine biosynthesis protein; KEGG: xau:Xaut_3531 histidine biosynthesis protein; Belongs to the HisA/HisF family. (232 aa) | ||||
groL | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa) | ||||
Snov_0580 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: xau:Xaut_3308 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) | ||||
gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (812 aa) | ||||
Snov_0560 | KEGG: bov:BOV_A0474 UDP-glucose 4-epimerase; TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (328 aa) | ||||
Snov_0450 | KEGG: azc:AZC_1773 putative methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase. (618 aa) | ||||
Snov_0449 | TIGRFAM: methylmalonyl-CoA mutase, large subunit; KEGG: azc:AZC_1772 methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein. (722 aa) | ||||
Snov_0431 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: azc:AZC_1810 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) | ||||
gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (207 aa) | ||||
Snov_0282 | PFAM: Asp/Glu/hydantoin racemase; KEGG: bja:blr5577 hydantoin racemase. (245 aa) | ||||
Snov_0250 | KEGG: azc:AZC_0138 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (282 aa) | ||||
fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (169 aa) | ||||
Snov_0243 | PFAM: 4-oxalocrotonate tautomerase; KEGG: bja:bll5259 hypothetical protein. (136 aa) | ||||
Snov_0157 | 4-hydroxyproline epimerase; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp, which would allow S.novella to grow on t4LHyp as a sole carbon source. (333 aa) | ||||
Snov_0155 | Proline racemase; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be involved in a degradation pathway that converts t3LHyp to L-proline, which would allow S.novella to grow on t3LHyp as a sole carbon source. (345 aa) | ||||
Snov_3580 | KEGG: mrd:Mrad2831_3408 Asp/Glu/hydantoin racemase. (222 aa) | ||||
hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: xau:Xaut_2290 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (247 aa) | ||||
Snov_3773 | TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; KEGG: sit:TM1040_3778 mannose-1-phosphate guanylyltransferase (GDP); PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa) | ||||
Snov_3772 | Phosphomannomutase; KEGG: rsk:RSKD131_2202 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase. (456 aa) | ||||
Snov_3648 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: har:HEAR2723 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa) | ||||
Snov_3617 | PFAM: Asp/Glu/hydantoin racemase; KEGG: pde:Pden_4618 Asp/Glu racemase. (256 aa) | ||||
Snov_0076 | PFAM: DSBA oxidoreductase; KEGG: azc:AZC_0543 2-hydroxychromene-2-carboxylate isomerase. (204 aa) | ||||
Snov_0083 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (193 aa) | ||||
Snov_0116 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (361 aa) | ||||
Snov_0152 | PFAM: amino acid permease-associated region; KEGG: mlo:mll6735 arginine/ornithine antiporter. (477 aa) | ||||
Snov_4289 | PFAM: N-acylglucosamine 2-epimerase; KEGG: smd:Smed_2871 mannose-6-phosphate isomerase. (395 aa) | ||||
Snov_4298 | PFAM: glucosamine/galactosamine-6-phosphate isomerase; KEGG: dfe:Dfer_3264 glucosamine/galactosamine-6-phosphate isomerase. (254 aa) | ||||
apaG | PFAM: ApaG domain protein; KEGG: azc:AZC_4024 ApaG. (130 aa) |