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| | pqqE | Coenzyme PQQ biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (380 aa) |
| | Snov_0053 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: nwi:Nwi_2773 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (183 aa) |
| | Snov_0065 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa) |
| | Snov_0068 | PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: azc:AZC_0393 putative ATP dependent DNA ligase. (568 aa) |
| | Snov_0083 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (193 aa) |
| | Snov_0085 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (297 aa) |
| | Snov_0092 | SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; KEGG: mno:Mnod_2110 oxygen-independent coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (439 aa) |
| | Snov_0094 | TIGRFAM: 5-aminolevulinic acid synthase; KEGG: xau:Xaut_2126 5-aminolevulinate synthase; PFAM: aminotransferase class I and II. (408 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (221 aa) |
| | Snov_0099 | PFAM: GTP cyclohydrolase II; KEGG: reh:H16_B1597 hypothetical protein. (422 aa) |
| | Snov_0100 | PFAM: protein of unknown function DUF1688; KEGG: bja:blr7238 hypothetical protein. (409 aa) |
| | Snov_0114 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: bid:Bind_3075 SMP-30/gluconolaconase/LRE domain-containing protein. (309 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | Snov_0206 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: rce:RC1_0589 cobalamin synthesis protein CobW, putative. (335 aa) |
| | Snov_0229 | PFAM: protein of unknown function DUF336; KEGG: pnu:Pnuc_0551 hypothetical protein. (145 aa) |
| | Snov_0240 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: xau:Xaut_4128 UBA/ThiF-type NAD/FAD binding protein. (280 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (251 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (208 aa) |
| | Snov_0274 | PFAM: aminotransferase class-III; KEGG: mno:Mnod_5513 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa) |
| | Snov_0296 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (409 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa) |
| | Snov_0340 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: nwi:Nwi_1654 glyoxalase/bleomycin resistance protein/dioxygenase. (140 aa) |
| | Snov_0352 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (532 aa) |
| | Snov_0396 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: azc:AZC_1400 putative oxidoreductase. (736 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (356 aa) |
| | Snov_0491 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (502 aa) |
| | Snov_0492 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: mex:Mext_2646 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (285 aa) |
| | Snov_0558 | TIGRFAM: nucleotide sugar dehydrogenase; KEGG: oan:Oant_4414 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (463 aa) |
| | Snov_0561 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: hne:HNE_2698 NAD-dependent epimerase/dehydratase family protein. (336 aa) |
| | Snov_0577 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (311 aa) |
| | Snov_0599 | KEGG: azc:AZC_2243 acetoacetyl-CoA synthetase; TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase. (655 aa) |
| | Snov_0656 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | Snov_0657 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; KEGG: xau:Xaut_2492 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (183 aa) |
| | Snov_0687 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: rpc:RPC_1525 deoxycytidine triphosphate deaminase; PFAM: deoxyUTP pyrophosphatase. (185 aa) |
| | Snov_0744 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | Snov_0754 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: xau:Xaut_4534 transcriptional coactivator/pterin dehydratase. (126 aa) |
| | Snov_0761 | PFAM: protein of unknown function DUF556; KEGG: xau:Xaut_4098 hypothetical protein. (243 aa) |
| | Snov_0763 | PFAM: dihydropteroate synthase DHPS; KEGG: xau:Xaut_4100 dihydropteroate synthase DhpS. (492 aa) |
| | Snov_0764 | PFAM: flavoprotein; KEGG: xau:Xaut_4101 flavoprotein. (187 aa) |
| | Snov_0819 | DNA ligase D; KEGG: rhi:NGR_b04710 putative ATP-dependent DNA ligase; TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; DNA primase small subunit. (842 aa) |
| | Snov_0825 | Nicotinamidase; KEGG: bja:bll4549 pyrazinamidase/nicotinamidase; PFAM: isochorismatase hydrolase. (218 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (265 aa) |
| | Snov_0877 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; KEGG: azc:AZC_4661 nitroreductase; PFAM: nitroreductase. (216 aa) |
| | cobT | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (340 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (348 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (557 aa) |
| | Snov_0921 | KEGG: hha:Hhal_1150 hypothetical protein. (396 aa) |
| | Snov_0933 | PFAM: aminotransferase class-III; KEGG: mlo:mll5149 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa) |
| | Snov_0934 | PFAM: aminotransferase class-III; KEGG: xau:Xaut_2727 putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (496 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (533 aa) |
| | Snov_0992 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: bja:bll6484 ECF sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (188 aa) |
| | Snov_1011 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sye:Syncc9902_1690 hypothetical protein. (324 aa) |
| | Snov_1012 | KEGG: rrs:RoseRS_2897 beta-lactamase domain-containing protein. (339 aa) |
| | pqqB | Coenzyme PQQ biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family. (312 aa) |
| | pqqC | Coenzyme PQQ biosynthesis protein C; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (245 aa) |
| | Snov_1056 | PFAM: coenzyme PQQ synthesis D; KEGG: rpd:RPD_2032 coenzyme PQQ synthesis D. (103 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (499 aa) |
| | Snov_1078 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (494 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (220 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (348 aa) |
| | Snov_1098 | PFAM: DNA polymerase III chi subunit HolC; KEGG: azc:AZC_0540 DNA polymerase III chi subunit. (148 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: azc:AZC_4161 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (359 aa) |
| | Snov_1151 | SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; KEGG: rde:RD1_1696 coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (454 aa) |
| | napA | Periplasmic nitrate reductase, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (831 aa) |
| | Snov_1186 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: bja:bll3116 phosphoribosylpyrophosphate synthetase; PFAM: phosphoribosyltransferase. (301 aa) |
| | Snov_1191 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: pzu:PHZ_c0646 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase. (340 aa) |
| | Snov_1209 | TIGRFAM: malonate decarboxylase, beta subunit; KEGG: mrd:Mrad2831_0169 malonate decarboxylase subunit beta. (309 aa) |
| | Snov_1217 | PFAM: protein of unknown function DUF336; KEGG: rhi:NGR_b16660 hypothetical protein. (149 aa) |
| | Snov_1253 | KEGG: pde:Pden_1128 von Willebrand factor, type A; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A. (313 aa) |
| | moaA-2 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (348 aa) |
| | Snov_1324 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (272 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1376 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1396 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (194 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (457 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; KEGG: azc:AZC_2851 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa) |
| | Snov_1535 | PFAM: protein of unknown function DUF344; KEGG: xau:Xaut_2307 hypothetical protein. (276 aa) |
| | Snov_1560 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: sme:SM_b20132 putative dehydrogenase. (789 aa) |
| | Snov_1562 | PFAM: molybdopterin dehydrogenase FAD-binding; KEGG: met:M446_0552 molybdopterin dehydrogenase FAD-binding. (281 aa) |
| | Snov_1569 | PFAM: aminotransferase class-III; KEGG: bbt:BBta_1928 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa) |
| | Snov_1604 | KEGG: bja:blr4374 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (341 aa) |
| | Snov_1612 | KEGG: gbr:Gbro_4379 protein of unknown function DUF201. (299 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (129 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (197 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (257 aa) |
| | Snov_1646 | Porphobilinogen synthase; KEGG: xau:Xaut_4295 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (353 aa) |
| | Snov_1654 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa) |
| | Snov_1655 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: xau:Xaut_4279 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (196 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (164 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (160 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (331 aa) |
| | ctaA | Cytochrome oxidase assembly; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (357 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (364 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (382 aa) |
| | Snov_1691 | KEGG: bpt:Bpet4671 molybdopterin-guanine dinucleotide biosynthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region. (179 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (202 aa) |
| | Snov_1758 | KEGG: met:M446_0318 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II. (464 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (243 aa) |
| | Snov_1771 | KEGG: azc:AZC_2174 putative DNA polymerase III delta prime subunit. (344 aa) |
| | Snov_1787 | PFAM: CinA domain protein; KEGG: azc:AZC_3090 CinA protein; Belongs to the CinA family. (171 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (325 aa) |
| | Snov_1793 | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (472 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (153 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (450 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | KEGG: azc:AZC_2205 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | Snov_1819 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (404 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (244 aa) |
| | Snov_1840 | TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: xau:Xaut_4284 DNA polymerase III subunit alpha; SMART: phosphoesterase PHP domain protein. (1149 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (494 aa) |
| | Snov_1936 | KEGG: dar:Daro_2209 hypothetical protein. (461 aa) |
| | Snov_1972 | KEGG: nmu:Nmul_A0535 hypothetical protein. (457 aa) |
| | folE | TIGRFAM: GTP cyclohydrolase I; KEGG: azc:AZC_0942 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (212 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (168 aa) |
| | Snov_2084 | PFAM: molybdopterin binding domain; KEGG: azc:AZC_1819 competence-damage associated protein. (247 aa) |
| | Snov_2094 | PFAM: Usg family protein; KEGG: xau:Xaut_4266 Usg family protein. (104 aa) |
| | Snov_2104 | KEGG: azc:AZC_1826 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (268 aa) |
| | Snov_2143 | KEGG: nwi:Nwi_2167 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: azc:AZC_2228 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (269 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (232 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa) |
| | Snov_2151 | PFAM: BolA family protein; KEGG: oca:OCAR_5454 BolA family protein; Belongs to the BolA/IbaG family. (77 aa) |
| | Snov_2164 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: pna:Pnap_3991 3-demethylubiquinone-9 3-methyltransferase. (138 aa) |
| | Snov_2166 | PFAM: thiamineS protein; KEGG: xau:Xaut_2823 thiamineS protein. (103 aa) |
| | Snov_2168 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: rpe:RPE_4735 RNA polymerase ECF-subfamily sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (411 aa) |
| | Snov_2178 | KEGG: cak:Caul_0759 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (181 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | Snov_2245 | PFAM: Creatininase; KEGG: psa:PST_1998 chain F, crystal structure of creatinine amidohydrolase (creatininase). (258 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa) |
| | Snov_2281 | TIGRFAM: para-aminobenzoate synthase, subunit I; KEGG: mno:Mnod_0053 para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein. (474 aa) |
| | Snov_2283 | PFAM: aminotransferase class IV; KEGG: mea:Mex_1p4282 putative branched-chain amino acid aminotransferase. (256 aa) |
| | Snov_2311 | TIGRFAM: pyridoxal kinase; KEGG: azc:AZC_1064 pyridoxamine kinase; PFAM: PfkB domain protein; Belongs to the pyridoxine kinase family. (282 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (666 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (645 aa) |
| | carA | KEGG: xau:Xaut_1243 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (400 aa) |
| | carB | KEGG: azc:AZC_1145 carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1111 aa) |
| | Snov_2453 | KEGG: mrd:Mrad2831_5403 molybdopterin converting factor, subunit 1; TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein. (83 aa) |
| | Snov_2454 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: azc:AZC_3969 molybdopterin converting factor subunit 2. (152 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (373 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | hemF | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (297 aa) |
| | Snov_2492 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mag:amb0232 dihydrofolate reductase. (176 aa) |
| | Snov_2525 | PFAM: protein of unknown function DUF336; KEGG: xau:Xaut_0298 hypothetical protein. (145 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (436 aa) |
| | Snov_2563 | KEGG: rlt:Rleg2_6025 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (252 aa) |
| | Snov_2564 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: xau:Xaut_3279 cobalamin biosynthesis protein G CbiG. (128 aa) |
| | Snov_2565 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: rle:pRL110626 precorrin-6y c(5,15)-methyltransferase [decarboxylating] (precorrin-6 methyltransferase) (precorrin-6y methylase); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (422 aa) |
| | Snov_2566 | TIGRFAM: precorrin-6x reductase; KEGG: xau:Xaut_3281 precorrin-6X reductase; PFAM: Precorrin-6x reductase CbiJ/CobK. (266 aa) |
| | Snov_2567 | TIGRFAM: precorrin-3B C17-methyltransferase; KEGG: rlt:Rleg2_6022 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (252 aa) |
| | Snov_2568 | KEGG: azc:AZC_3938 precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (251 aa) |
| | Snov_2569 | KEGG: xau:Xaut_3284 precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase CbiC/CobH. (211 aa) |
| | Snov_2571 | TIGRFAM: cobaltochelatase, CobN subunit; KEGG: mlo:mlr1377 cobaltochelatase subunit CobN; PFAM: CobN/magnesium chelatase. (1160 aa) |
| | Snov_2572 | KEGG: xau:Xaut_3287 cobalamin biosynthesis protein CobW; TIGRFAM: cobalamin biosynthesis protein CobW; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein. (352 aa) |
| | Snov_2576 | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (168 aa) |
| | Snov_2577 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (204 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (489 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (324 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (201 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (271 aa) |
| | Snov_2602 | KEGG: avi:Avi_5919 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein. (65 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (303 aa) |
| | Snov_2768 | KEGG: app:CAP2UW1_0667 ATP/cobalamin adenosyltransferase; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (203 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | Snov_2799 | PFAM: BolA family protein; KEGG: azc:AZC_3676 hypothetical protein; Belongs to the BolA/IbaG family. (97 aa) |
| | Snov_2802 | Cobalt chelatase, pCobT subunit; SMART: von Willebrand factor type A; TIGRFAM: cobalt chelatase, pCobT subunit; KEGG: xau:Xaut_1878 cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit. (659 aa) |
| | Snov_2805 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: xau:Xaut_1732 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (529 aa) |
| | Snov_2831 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: azc:AZC_0565 putative CobW protein. (324 aa) |
| | Snov_2837 | PFAM: Creatininase; KEGG: msl:Msil_1161 creatininase. (272 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (603 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | Snov_3057 | KEGG: azc:AZC_0508 antifreeze protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (201 aa) |
| | Snov_3075 | PFAM: thiamine monophosphate synthase; KEGG: nha:Nham_3535 thiamine monophosphate synthase. (217 aa) |
| | Snov_3078 | PFAM: protein of unknown function DUF179; KEGG: xau:Xaut_2594 hypothetical protein; Belongs to the UPF0301 (AlgH) family. (208 aa) |
| | Snov_3083 | PFAM: AMP-dependent synthetase and ligase; KEGG: bbt:BBta_0943 putative propionate--CoA ligase. (641 aa) |
| | Snov_3092 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (169 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa) |
| | murD | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa) |
| | Snov_3176 | PFAM: aldo/keto reductase; KEGG: atc:AGR_L_1141 hypothetical protein. (277 aa) |
| | Snov_3206 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: rsq:Rsph17025_4099 hypothetical protein. (339 aa) |
| | Snov_3210 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: kse:Ksed_18630 nucleoside-diphosphate-sugar epimerase. (379 aa) |
| | Snov_3257 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: oan:Oant_3342 SMP-30/gluconolaconase/LRE domain-containing protein. (298 aa) |
| | Snov_3266 | KEGG: xau:Xaut_2674 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (172 aa) |
| | Snov_3292 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: azc:AZC_1001 CobW protein. (376 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (729 aa) |
| | Snov_3332 | Isochorismatase; KEGG: pde:Pden_2383 isochorismatase; PFAM: isochorismatase hydrolase. (218 aa) |
| | Snov_3337 | TIGRFAM: nucleotide sugar dehydrogenase; KEGG: azc:AZC_2260 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (438 aa) |
| | Snov_3386 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; [2Fe-2S]-binding domain protein; ferredoxin; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: mno:Mnod_4657 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (904 aa) |
| | Snov_3390 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (214 aa) |
| | Snov_3407 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: azc:AZC_4610 hypoxanthine phosphoribosyl transferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (201 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (221 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (445 aa) |
| | Snov_3449 | PFAM: TspO/MBR family protein; KEGG: xau:Xaut_2163 TspO and MBR like protein. (158 aa) |
| | Snov_3451 | ATP/cobalamin adenosyltransferase; KEGG: bmc:BAbS19_I18540 protein of unknown function DUF80; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (199 aa) |
| | Snov_3457 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: gvi:glr1439 hypothetical protein. (298 aa) |
| | Snov_3481 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (230 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (477 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa) |
| | Snov_3494 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: bbt:BBta_5514 putative dihydrokaempferol 4-reductase (NAD-dependent epimerase/dehydratase). (341 aa) |
| | Snov_3497 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: mrd:Mrad2831_1356 putative circadian phase modifier CpmA-like protein. (220 aa) |
| | Snov_3504 | KEGG: sme:SMa0002 FdoG formate dehydrogenase-O alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; Contains Selenocysteine; PFAM: molybdopterin oxidoreductase Fe4S4 region; Twin-arginine translocation pathway, signal sequence, subgroup; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1028 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (475 aa) |
| | Snov_3534 | TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; KEGG: azc:AZC_1356 formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (766 aa) |
| | Snov_3578 | TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: hmo:HM1_2672 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (334 aa) |
| | Snov_3594 | PFAM: aldo/keto reductase; KEGG: tbd:Tbd_1200 putative oxidoreductase protein. (305 aa) |
| | Snov_3597 | KEGG: mpo:Mpop_4405 dihydrofolate reductase. (135 aa) |
| | Snov_3611 | PFAM: Creatininase; KEGG: psa:PST_1998 chain F, crystal structure of creatinine amidohydrolase (creatininase). (259 aa) |
| | Snov_3643 | KEGG: pag:PLES_16511 putative sigma-70 factor, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (164 aa) |
| | Snov_3644 | TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: pap:PSPA7_3077 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (342 aa) |
| | Snov_3678 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: rhi:NGR_c22230 putative reductase protein. (176 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (397 aa) |
| | Snov_3695 | KEGG: met:M446_4806 RNA polymerase factor sigma-32; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein. (293 aa) |
| | Snov_3704 | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (205 aa) |
| | Snov_3716 | PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: azc:AZC_0069 putative selenophosphate synthetase-related protein. (332 aa) |
| | Snov_3734 | KEGG: met:M446_4784 hypothetical protein. (133 aa) |
| | Snov_3738 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: met:M446_2359 deaminase-reductase domain-containing protein. (241 aa) |
| | Snov_3740 | PFAM: NUDIX hydrolase; KEGG: mjl:Mjls_2909 NUDIX hydrolase. (153 aa) |
| | nadE-2 | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (680 aa) |
| | Snov_3743 | PFAM: protein of unknown function DUF344; KEGG: gbe:GbCGDNIH1_1622 polyphosphate kinase. (306 aa) |
| | Snov_3801 | KEGG: xau:Xaut_1448 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta. (340 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa) |
| | Snov_3810 | PFAM: conserved hypothetical protein; KEGG: xau:Xaut_1825 hypothetical protein. (141 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (232 aa) |
| | coaA | TIGRFAM: pantothenate kinase; KEGG: azc:AZC_4496 pantothenate kinase. (320 aa) |
| | Snov_3840 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (277 aa) |
| | cmk | KEGG: xau:Xaut_1111 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (209 aa) |
| | Snov_3866 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (272 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (361 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (981 aa) |
| | Snov_3877 | KEGG: xau:Xaut_1415 dihydroorotase; TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. (457 aa) |
| | Snov_3881 | KEGG: azc:AZC_0098 riboflavin kinase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (316 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (536 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: xau:Xaut_1412 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (425 aa) |
| | Snov_3922 | TIGRFAM: FolC bifunctional protein; KEGG: azc:AZC_1025 folylpolyglutamate synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein. (447 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpF | KEGG: rpb:RPB_0636 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (236 aa) |
| | Snov_3944 | SMART: metal-dependent phosphohydrolase HD region; KEGG: xau:Xaut_1475 metal dependent phosphohydrolase. (223 aa) |
| | Snov_3975 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: rsk:RSKD131_3273 transcriptional regulator, fis family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (242 aa) |
| | queG | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (388 aa) |
| | Snov_4037 | PFAM: protein of unknown function DUF344; KEGG: mes:Meso_0013 hypothetical protein. (321 aa) |
| | Snov_4053 | PFAM: Protein of unknown function DUF2478; KEGG: mch:Mchl_5508 hypothetical protein. (193 aa) |
| | Snov_4180 | Dihydropyrimidinase; KEGG: mes:Meso_2664 phenylhydantoinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (485 aa) |
| | Snov_4211 | KEGG: rhi:NGR_b13630 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (321 aa) |
| | Snov_4237 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: bja:blr3350 carbon monoxide dehydrogenase large chain. (780 aa) |
| | Snov_4264 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: avi:Avi_5884 hypothetical protein. (348 aa) |
| | Snov_4266 | Dihydropyrimidinase; KEGG: mno:Mnod_7926 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (475 aa) |
| | Snov_4268 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: mno:Mnod_8560 NAD-dependent epimerase/dehydratase. (309 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1140 aa) |
| | Snov_4418 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (187 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (254 aa) |
| | atpE | H+transporting two-sector ATPase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpF | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (204 aa) |
| | atpF-2 | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (160 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (640 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (434 aa) |
| | Snov_4452 | PFAM: aminotransferase class-III; KEGG: xau:Xaut_2299 beta alanine--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa) |
| | Snov_4460 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (499 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (658 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: azc:AZC_4024 ApaG. (130 aa) |
| | Snov_4502 | SMART: DNA polymerase III beta chain; TIGRFAM: DNA polymerase III, beta subunit; KEGG: mrd:Mrad2831_2239 DNA polymerase III subunit beta; PFAM: DNA polymerase III beta chain. (406 aa) |
