STRINGSTRING
Snov_0241 Snov_0241 Snov_0276 Snov_0276 Snov_0337 Snov_0337 Snov_0414 Snov_0414 glyA glyA cbbL cbbL Snov_0429 Snov_0429 Snov_0449 Snov_0449 Snov_0450 Snov_0450 Snov_0451 Snov_0451 Snov_0452 Snov_0452 purU purU Snov_0482 Snov_0482 glcB glcB Snov_0815 Snov_0815 gph gph Snov_0935 Snov_0935 Snov_1020 Snov_1020 Snov_1175 Snov_1175 Snov_1310 Snov_1310 Snov_1602 Snov_1602 Snov_1606 Snov_1606 glyA-2 glyA-2 Snov_1745 Snov_1745 Snov_1791 Snov_1791 Snov_1825 Snov_1825 Snov_1847 Snov_1847 Snov_1922 Snov_1922 Snov_2213 Snov_2213 Snov_2222 Snov_2222 Snov_2326 Snov_2326 Snov_2425 Snov_2425 Snov_2530 Snov_2530 Snov_2736 Snov_2736 Snov_2737 Snov_2737 acsA acsA Snov_2978 Snov_2978 Snov_2983 Snov_2983 Snov_2984 Snov_2984 Snov_2985 Snov_2985 Snov_2999 Snov_2999 Snov_3108 Snov_3108 Snov_3272 Snov_3272 mdh mdh Snov_3303 Snov_3303 Snov_3489 Snov_3489 Snov_3504 Snov_3504 Snov_3505 Snov_3505 Snov_3506 Snov_3506 Snov_3533 Snov_3533 Snov_3565 Snov_3565 Snov_3661 Snov_3661 Snov_3749 Snov_3749 Snov_3849 Snov_3849 Snov_3850 Snov_3850 Snov_3851 Snov_3851 Snov_3853 Snov_3853 Snov_3891 Snov_3891 Snov_3893 Snov_3893 Snov_3894 Snov_3894 Snov_4156 Snov_4156
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Snov_0241KEGG: xau:Xaut_4126 glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region. (333 aa)
Snov_0276PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: xau:Xaut_2473 hydrolase. (241 aa)
Snov_0337Glutamate--putrescine ligase; KEGG: azc:AZC_4442 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region. (466 aa)
Snov_0414KEGG: met:M446_4572 glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (344 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
cbbLRibulose-bisphosphate carboxylase; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (489 aa)
Snov_0429KEGG: bbt:BBta_0452 ribulose 1,5-bisphosphate carboxylase small subunit; PFAM: ribulose bisphosphate carboxylase small chain. (139 aa)
Snov_0449TIGRFAM: methylmalonyl-CoA mutase, large subunit; KEGG: azc:AZC_1772 methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein. (722 aa)
Snov_0450KEGG: azc:AZC_1773 putative methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase. (618 aa)
Snov_0451PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; KEGG: xau:Xaut_4726 carbamoyl-phosphate synthase L chain ATP-binding. (675 aa)
Snov_0452PFAM: carboxyl transferase; KEGG: azc:AZC_1775 propionyl-CoA carboxylase. (510 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
Snov_0482KEGG: rpc:RPC_1050 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (370 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
Snov_0815Isocitrate lyase; KEGG: scl:sce8726 hypothetical protein; TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase. (432 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (233 aa)
Snov_0935Glutamate--putrescine ligase; KEGG: azc:AZC_3648 putative glutamine synthetase protein; PFAM: glutamine synthetase catalytic region. (469 aa)
Snov_1020Aconitate hydratase domain protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (867 aa)
Snov_1175Formamidase; KEGG: oca:OCAR_7088 formamidase; PFAM: Acetamidase/Formamidase. (408 aa)
Snov_1310TIGRFAM: bicupin, oxalate decarboxylase family; KEGG: atc:AGR_L_224 putative oxalate decarboxylase; PFAM: Cupin domain protein. (398 aa)
Snov_1602TIGRFAM: tartrate dehydrogenase; KEGG: mno:Mnod_1445 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (368 aa)
Snov_1606TIGRFAM: tartrate dehydrogenase; KEGG: reu:Reut_C5899 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (361 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
Snov_1745KEGG: met:M446_3126 2-hydroxy-3-oxopropionate reductase; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. (303 aa)
Snov_1791KEGG: xau:Xaut_3894 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (472 aa)
Snov_1825TIGRFAM: citrate synthase I; KEGG: xau:Xaut_4425 citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (436 aa)
Snov_1847TIGRFAM: methylmalonyl-CoA epimerase; KEGG: xau:Xaut_4617 methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (134 aa)
Snov_1922KEGG: mrd:Mrad2831_3407 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (260 aa)
Snov_2213KEGG: pla:Plav_2768 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase. (223 aa)
Snov_2222KEGG: azc:AZC_1601 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (469 aa)
Snov_2326PFAM: Alpha/beta hydrolase fold-3 domain protein; KEGG: azc:AZC_4299 putative esterase. (309 aa)
Snov_2425Formamidase; KEGG: azc:AZC_4101 formamidase; PFAM: Acetamidase/Formamidase. (409 aa)
Snov_2530PFAM: aminotransferase class V; KEGG: rme:Rmet_5630 aminotransferase, class V. (401 aa)
Snov_2736KEGG: rhi:NGR_c32710 acetoacetyl-CoA reductase; TIGRFAM: acetoacetyl-CoA reductase; PFAM: short-chain dehydrogenase/reductase SDR. (241 aa)
Snov_2737KEGG: bja:bll0226 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
Snov_2978KEGG: xau:Xaut_0486 putative oxalyl-CoA decarboxylase; TIGRFAM: oxalyl-CoA decarboxylase; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (579 aa)
Snov_2983KEGG: azc:AZC_3488 glyoxylate carboligase; TIGRFAM: glyoxylate carboligase; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (588 aa)
Snov_2984TIGRFAM: hydroxypyruvate isomerase; KEGG: oca:OCAR_6561 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (261 aa)
Snov_2985TIGRFAM: 2-hydroxy-3-oxopropionate reductase; KEGG: xau:Xaut_2369 2-hydroxy-3-oxopropionate reductase; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. (296 aa)
Snov_2999KEGG: azc:AZC_0561 4-hydroxy-2-oxoglutarate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase. (214 aa)
Snov_3108KEGG: mrd:Mrad2831_0126 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (430 aa)
Snov_3272D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (401 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa)
Snov_3303KEGG: xau:Xaut_0159 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (466 aa)
Snov_3489Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (894 aa)
Snov_3504KEGG: sme:SMa0002 FdoG formate dehydrogenase-O alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; Contains Selenocysteine; PFAM: molybdopterin oxidoreductase Fe4S4 region; Twin-arginine translocation pathway, signal sequence, subgroup; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1028 aa)
Snov_3505KEGG: oan:Oant_2864 formate dehydrogenase, beta subunit; TIGRFAM: formate dehydrogenase, beta subunit; PFAM: Formate dehydrogenase transmembrane domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (329 aa)
Snov_3506TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: azc:AZC_1157 formate dehydrogenase gamma subunit. (237 aa)
Snov_3533TIGRFAM: bicupin, oxalate decarboxylase family; KEGG: atc:AGR_L_224 putative oxalate decarboxylase; PFAM: Cupin domain protein. (415 aa)
Snov_3565KEGG: mno:Mnod_1037 N-formylglutamate amidohydrolase; TIGRFAM: N-formylglutamate amidohydrolase; PFAM: N-formylglutamate amidohydrolase. (274 aa)
Snov_3661KEGG: mno:Mnod_3435 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; PFAM: ribulose bisphosphate carboxylase large chain; Ribulose bisphosphate carboxylase, large subunit-like; Belongs to the RuBisCO large chain family. (420 aa)
Snov_3749Catalase related subgroup; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (383 aa)
Snov_3849PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: bja:bll3138 formate dehydrogenase subunit gamma. (157 aa)
Snov_3850NADH dehydrogenase (quinone); KEGG: azc:AZC_3453 putative NAD-dependent formate dehydrogenase beta subunit protein; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding. (519 aa)
Snov_3851KEGG: xau:Xaut_3479 formate dehydrogenase, alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molydopterin dinucleotide-binding region. (951 aa)
Snov_3853Hypothetical protein; KEGG: bja:bsl3134 putative NAD-dependent formate dehydrogenase. (95 aa)
Snov_3891D-lactate dehydrogenase (cytochrome); KEGG: azc:AZC_0083 glycolate oxidase subunit protein; PFAM: FAD linked oxidase domain protein. (498 aa)
Snov_3893PFAM: FAD linked oxidase domain protein; KEGG: xau:Xaut_1869 FAD linked oxidase domain-containing protein. (415 aa)
Snov_3894PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: azc:AZC_0080 glycolate oxidase. (439 aa)
Snov_4156PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: pst:PSPTO_0258 D-isomer specific 2-hydroxyacid dehydrogenase family protein. (312 aa)
Your Current Organism:
Starkeya novella
NCBI taxonomy Id: 639283
Other names: S. novella DSM 506, Starkeya novella DSM 506, Starkeya novella IAM 12100, Starkeya novella str. DSM 506, Starkeya novella strain DSM 506
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