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| | Snov_0115 | KEGG: atc:AGR_L_3190 putative dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (601 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | Snov_0173 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: mrd:Mrad2831_4405 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (329 aa) |
| | Snov_0175 | PFAM: dihydrodipicolinate synthetase; KEGG: bbr:BB4720 putative dihydrodipicolinate synthase; Belongs to the DapA family. (309 aa) |
| | Snov_0250 | KEGG: azc:AZC_0138 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (282 aa) |
| | Snov_0299 | KEGG: azc:AZC_0709 cysteine synthase K/M; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (325 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (207 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa) |
| | Snov_0326 | KEGG: azc:AZC_2376 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (586 aa) |
| | Snov_0327 | KEGG: xau:Xaut_1489 acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (171 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | Snov_0337 | Glutamate--putrescine ligase; KEGG: azc:AZC_4442 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region. (466 aa) |
| | Snov_0414 | KEGG: met:M446_4572 glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (344 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | Snov_0426 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (674 aa) |
| | Snov_0427 | Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (361 aa) |
| | Snov_0431 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: azc:AZC_1810 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | Snov_0571 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; KEGG: mrd:Mrad2831_2117 thiamine pyrophosphate protein; Belongs to the TPP enzyme family. (563 aa) |
| | Snov_0592 | TIGRFAM: threonine synthase; KEGG: azc:AZC_2239 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (469 aa) |
| | Snov_0653 | PFAM: aminotransferase class IV; KEGG: mno:Mnod_1805 aminotransferase class IV. (286 aa) |
| | Snov_0747 | PFAM: histidine biosynthesis protein; KEGG: xau:Xaut_3531 histidine biosynthesis protein; Belongs to the HisA/HisF family. (232 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa) |
| | Snov_0906 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: bja:blr3778 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II. (461 aa) |
| | Snov_0935 | Glutamate--putrescine ligase; KEGG: azc:AZC_3648 putative glutamine synthetase protein; PFAM: glutamine synthetase catalytic region. (469 aa) |
| | Snov_1020 | Aconitate hydratase domain protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (867 aa) |
| | Snov_1022 | KEGG: rso:RSp0329 3-isopropylmalate dehydrogenase oxidoreductase protein; PFAM: isocitrate/isopropylmalate dehydrogenase. (363 aa) |
| | Snov_1127 | Arginase; KEGG: mes:Meso_3963 arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (305 aa) |
| | Snov_1186 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: bja:bll3116 phosphoribosylpyrophosphate synthetase; PFAM: phosphoribosyltransferase. (301 aa) |
| | Snov_1191 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: pzu:PHZ_c0646 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase. (340 aa) |
| | Snov_1293 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: tmz:Tmz1t_1850 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (347 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | Snov_1365 | KEGG: azc:AZC_1848 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (439 aa) |
| | Snov_1396 | TIGRFAM: cystathionine beta-lyase; KEGG: azc:AZC_1584 cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (403 aa) |
| | Snov_1403 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: xau:Xaut_4677 pyridoxal-5'-phosphate-dependent protein beta subunit. (343 aa) |
| | Snov_1529 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: rpd:RPD_2099 hypothetical protein. (318 aa) |
| | Snov_1601 | KEGG: acr:Acry_1270 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | Snov_1644 | KEGG: xau:Xaut_4294 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (408 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa) |
| | Snov_1740 | KEGG: met:M446_3131 ribose-5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (148 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | Snov_1815 | KEGG: xau:Xaut_4377 glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (202 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | KEGG: azc:AZC_2205 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | Snov_1825 | TIGRFAM: citrate synthase I; KEGG: xau:Xaut_4425 citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (436 aa) |
| | Snov_1893 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (249 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: met:M446_5056 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (575 aa) |
| | Snov_1919 | KEGG: met:M446_1318 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (573 aa) |
| | Snov_1921 | PFAM: dihydrodipicolinate synthetase; KEGG: azc:AZC_0731 dihydrodipicolinate synthetase; Belongs to the DapA family. (314 aa) |
| | Snov_2003 | KEGG: mlo:mlr4651 cysteine synthase; TIGRFAM: cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (361 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (161 aa) |
| | Snov_2025 | TIGRFAM: serine O-acetyltransferase; KEGG: rpc:RPC_3144 serine O-acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein. (283 aa) |
| | Snov_2113 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: xau:Xaut_4110 pyridoxal-5'-phosphate-dependent protein beta subunit. (329 aa) |
| | Snov_2141 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: bra:BRADO2842 ribulose-phosphate 3-epimerase (pentose-5-phosphate 3-epimerase) (PPE) (R5P3E); PFAM: ribulose-phosphate 3-epimerase. (228 aa) |
| | Snov_2160 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: azc:AZC_1865 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa) |
| | Snov_2222 | KEGG: azc:AZC_1601 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (469 aa) |
| | Snov_2283 | PFAM: aminotransferase class IV; KEGG: mea:Mex_1p4282 putative branched-chain amino acid aminotransferase. (256 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa) |
| | Snov_2320 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1244 aa) |
| | Snov_2367 | PFAM: aminotransferase class I and II; KEGG: xau:Xaut_2737 aminotransferase class I and II. (400 aa) |
| | ilvD-2 | TIGRFAM: dihydroxy-acid dehydratase; KEGG: mpo:Mpop_2797 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (610 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (373 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | Snov_2522 | PFAM: dihydrodipicolinate synthetase; KEGG: mag:amb2543 dihydrodipicolinate synthase; Belongs to the DapA family. (300 aa) |
| | Snov_2622 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: nar:Saro_1061 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (371 aa) |
| | Snov_2629 | KEGG: azc:AZC_0201 acetylornithine deacetylase; TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein. (382 aa) |
| | Snov_2638 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: mes:Meso_3309 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (316 aa) |
| | Snov_2713 | KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein. (1576 aa) |
| | Snov_2714 | KEGG: xau:Xaut_0476 glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (474 aa) |
| | Snov_2718 | PFAM: dihydrodipicolinate synthetase; KEGG: smd:Smed_4167 dihydrodipicolinate synthetase; Belongs to the DapA family. (298 aa) |
| | Snov_2723 | KEGG: xau:Xaut_2625 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (416 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (369 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | Snov_2767 | KEGG: avi:Avi_5923 pyruvate kinase; PFAM: Pyruvate kinase barrel; Belongs to the pyruvate kinase family. (501 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (412 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (201 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (386 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa) |
| | Snov_2887 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: nar:Saro_1061 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (372 aa) |
| | Snov_2965 | PFAM: aminotransferase class I and II; KEGG: azc:AZC_0558 aspartate aminotransferase. (401 aa) |
| | Snov_3003 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: xau:Xaut_1202 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (528 aa) |
| | Snov_3004 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (391 aa) |
| | Snov_3011 | TIGRFAM: L-serine dehydratase 1; KEGG: msl:Msil_1803 L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | Snov_3069 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | Snov_3070 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: bid:Bind_3468 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | pgk | KEGG: azc:AZC_0502 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | Snov_3072 | KEGG: xau:Xaut_3077 fructose-bisphosphate aldolase; PFAM: fructose-bisphosphate aldolase class-I. (340 aa) |
| | thrB | TIGRFAM: homoserine kinase; KEGG: xau:Xaut_2356 homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | Snov_3118 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: bra:BRADO5568 phosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) (PSPase); PFAM: Haloacid dehalogenase domain protein hydrolase. (297 aa) |
| | Snov_3158 | TIGRFAM: dihydrodipicolinate reductase; KEGG: chl:Chy400_1397 dihydrodipicolinate reductase; PFAM: dihydrodipicolinate reductase; protein of unknown function DUF1611; Belongs to the DapB family. (269 aa) |
| | Snov_3163 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1154 aa) |
| | Snov_3164 | TIGRFAM: pyruvate kinase; KEGG: azc:AZC_3491 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (516 aa) |
| | Snov_3289 | KEGG: rpb:RPB_0869 phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; Belongs to the PRA-PH family. (139 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: xau:Xaut_2013 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (445 aa) |
| | argH | KEGG: xau:Xaut_1738 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (458 aa) |
| | Snov_3470 | KEGG: xau:Xaut_0393 arogenate dehydrogenase; PFAM: Prephenate dehydrogenase. (311 aa) |
| | hisC | KEGG: xau:Xaut_0394 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (396 aa) |
| | Snov_3489 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (894 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (397 aa) |
| | Snov_3710 | Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (350 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa) |
| | hisB | KEGG: azc:AZC_4502 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (220 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: xau:Xaut_2290 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (247 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa) |
| | hisE | KEGG: azc:AZC_4497 phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase. (112 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (453 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpF | KEGG: rpb:RPB_0636 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (236 aa) |
| | Snov_3955 | TIGRFAM: S-adenosylmethionine synthetase; KEGG: xau:Xaut_1816 methionine adenosyltransferase; PFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (397 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (323 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (305 aa) |
| | dapD | KEGG: azc:AZC_0214 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (280 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (397 aa) |
| | Snov_4067 | KEGG: bja:bll6321 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa) |
| | arcB | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa) |
| | Snov_4225 | KEGG: bbe:BBR47_20960 putative acetylornithine deacetylase; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20. (424 aa) |
| | Snov_4229 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: hoh:Hoch_3415 pyridoxal-5'-phosphate-dependent protein beta subunit. (496 aa) |
| | Snov_4249 | KEGG: atc:AGR_L_2847 acetylornithine deacetylase; TIGRFAM: acetylornithine deacetylase (ArgE); acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein. (376 aa) |
| | Snov_4324 | KEGG: pol:Bpro_5111 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | Snov_4333 | KEGG: rhi:NGR_c25920 homoisocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (361 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | Snov_4458 | PFAM: tRNA synthetase class II (G H P and S); KEGG: xau:Xaut_4746 ATP phosphoribosyltransferase regulatory subunit. (372 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (323 aa) |
| | Snov_4489 | TIGRFAM: acetylornithine deacetylase (ArgE); KEGG: met:M446_6541 acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein. (387 aa) |
| | arcB-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (316 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: azc:AZC_4028 acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa) |
