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serC serC Srot_0313 Srot_0313 Srot_0327 Srot_0327 trpA trpA trpB trpB trpC trpC trpE trpE Srot_0489 Srot_0489 Srot_0540 Srot_0540 hisA hisA hisF hisF hisI hisI Srot_0738 Srot_0738 trpD trpD Srot_1070 Srot_1070 Srot_1367 Srot_1367 Srot_1507 Srot_1507 Srot_1641 Srot_1641 Srot_1646 Srot_1646 Srot_1829 Srot_1829 hisH hisH hisB hisB hisC hisC hisD hisD Srot_1834 Srot_1834 hisG hisG Srot_1868 Srot_1868 aroQ aroQ aroB aroB aroK aroK aroC aroC Srot_2054 Srot_2054 aroA aroA Srot_2244 Srot_2244 Srot_2322 Srot_2322 Srot_2323 Srot_2323 Srot_2448 Srot_2448 Srot_2634 Srot_2634 Srot_3056 Srot_3056
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene fusions
gene co-occurrence
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textmining
co-expression
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serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
Srot_0313KEGG: msm:MSMEG_6418 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (309 aa)
Srot_0327KEGG: mab:MAB_0032 para-aminobenzoate synthase component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (213 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
trpCKEGG: nfa:nfa18600 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (271 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (521 aa)
Srot_0489KEGG: mkm:Mkms_2781 chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase, type II. (191 aa)
Srot_0540PFAM: Prephenate dehydrogenase; KEGG: rer:RER_03280 prephenate dehydrogenase. (317 aa)
hisATIGRFAM: bifunctional HisA/TrpF protein; KEGG: nfa:nfa18500 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase; PFAM: histidine biosynthesis protein. (248 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (267 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa)
Srot_0738Salicylate synthase; KEGG: rop:ROP_23300 putative salicylate synthetase; TIGRFAM: salicylate synthase; PFAM: Chorismate binding-like. (433 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (358 aa)
Srot_1070TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: nfa:nfa17320 putative 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) synthase II; PFAM: DAHP synthetase class II. (465 aa)
Srot_1367TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); KEGG: nfa:nfa42930 putative phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (420 aa)
Srot_1507KEGG: rop:ROP_42480 hypothetical protein; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase- like); PFAM: Haloacid dehalogenase domain protein hydrolase. (281 aa)
Srot_1641KEGG: rop:ROP_17280 putative hydrolase; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase- like); PFAM: Haloacid dehalogenase domain protein hydrolase. (326 aa)
Srot_1646Shikimate-5-dehydrogenase; KEGG: mab:MAB_2848c shikimate 5-dehydrogenase; TIGRFAM: shikimate-5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (276 aa)
Srot_1829PFAM: Thioredoxin domain; KEGG: rop:ROP_11650 putative thioredoxin. (311 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisBKEGG: mjl:Mjls_3077 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (205 aa)
hisCKEGG: ami:Amir_5721 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa)
Srot_1834KEGG: hypothetical protein. (77 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (284 aa)
Srot_1868KEGG: mgi:Mflv_3056 phosphoribosyl-ATP pyrophosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; Belongs to the PRA-PH family. (90 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (370 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (403 aa)
Srot_2054KEGG: mav:MAV_3847 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (531 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa)
Srot_2244TIGRFAM: para-aminobenzoate synthase, subunit I; KEGG: mjl:Mjls_4651 aminodeoxychorismate synthase component I; PFAM: Chorismate binding-like. (418 aa)
Srot_2322PFAM: peptidase M24; creatinase; KEGG: ami:Amir_5250 peptidase M24; Belongs to the peptidase M24B family. (374 aa)
Srot_2323KEGG: hypothetical LOC585658. (240 aa)
Srot_2448KEGG: fal:FRAAL4639 2-epi-5-epi-valiolone synthase (partial match); PFAM: 3-dehydroquinate synthase. (391 aa)
Srot_2634Chorismate mutase; KEGG: nfa:nfa49960 hypothetical protein; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase, type II. (93 aa)
Srot_3056PFAM: aminotransferase class IV; KEGG: rer:RER_48190 aminotransferase. (285 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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