STRINGSTRING
recF recF Srot_0106 Srot_0106 Srot_0143 Srot_0143 Srot_0184 Srot_0184 Srot_0195 Srot_0195 Srot_0196 Srot_0196 Srot_0245 Srot_0245 Srot_0309 Srot_0309 Srot_0386 Srot_0386 Srot_0432 Srot_0432 Srot_0445 Srot_0445 Srot_0529 Srot_0529 uvrC uvrC uvrB uvrB Srot_0707 Srot_0707 Srot_0739 Srot_0739 Srot_0748 Srot_0748 Srot_0785 Srot_0785 recA recA lexA lexA Srot_0964 Srot_0964 Srot_1012 Srot_1012 Srot_1053 Srot_1053 Srot_1076 Srot_1076 Srot_1100 Srot_1100 Srot_1173 Srot_1173 Srot_1306 Srot_1306 Srot_1307 Srot_1307 Srot_1315 Srot_1315 Srot_1353 Srot_1353 Srot_1382 Srot_1382 ruvA ruvA ruvB ruvB Srot_1451 Srot_1451 lnt lnt uvrA uvrA Srot_2049 Srot_2049 Srot_2060 Srot_2060 Srot_2189 Srot_2189 Srot_2366 Srot_2366 Srot_2427 Srot_2427 Srot_2430 Srot_2430 Srot_2438 Srot_2438 Srot_2455 Srot_2455 Srot_2459 Srot_2459 Srot_2494 Srot_2494 Srot_2496 Srot_2496 dinB dinB Srot_2612 Srot_2612 Srot_2684 Srot_2684 Srot_2745 Srot_2745 Srot_2757 Srot_2757 Srot_2805 Srot_2805 Srot_2840 Srot_2840 Srot_2949 Srot_2949 msrA msrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (401 aa)
Srot_0106KEGG: npu:Npun_R6310 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase. (314 aa)
Srot_0143PFAM: cutinase; KEGG: mva:Mvan_1441 cutinase. (278 aa)
Srot_0184Allophanate hydrolase subunit 1; KEGG: rer:RER_06990 hypothetical protein; PFAM: Allophanate hydrolase subunit 1; SMART: Allophanate hydrolase subunit 1. (200 aa)
Srot_0195PFAM: acyl-CoA dehydrogenase domain protein; KEGG: mav:MAV_4914 putative acyl-CoA dehydrogenase. (611 aa)
Srot_0196PFAM: acyl-CoA dehydrogenase domain protein; KEGG: msm:MSMEG_0406 acyl-CoA-dehydrogenase. (611 aa)
Srot_0245Putative F420-dependent enzyme; KEGG: gbr:Gbro_3771 PPOX class putative F420- dependent enzyme; TIGRFAM: putative F420-dependent enzyme; PFAM: pyridoxamine 5'-phosphate oxidase-related FMN- binding. (147 aa)
Srot_0309KEGG: nfa:nfa42700 hypothetical protein; Belongs to the WXG100 family. (99 aa)
Srot_0386beta-Ig-H3/fasciclin; KEGG: rer:RER_19270 hypothetical protein; PFAM: beta-Ig-H3/fasciclin; SMART: beta-Ig-H3/fasciclin. (208 aa)
Srot_0432Lsr2; KEGG: mjl:Mjls_5143 Lsr2. (113 aa)
Srot_0445PFAM: transcription factor CarD; KEGG: mmi:MMAR_5083 transcriptional regulatory protein. (162 aa)
Srot_0529PFAM: TAP domain protein; alpha/beta hydrolase fold; KEGG: rha:RHA1_ro01168 proteinase. (531 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (650 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (706 aa)
Srot_0707KEGG: gbr:Gbro_2971 hypothetical protein. (108 aa)
Srot_0739PFAM: AMP-dependent synthetase and ligase; KEGG: rop:ROP_23290 2,3-dihydroxybenzoate-AMP ligase. (505 aa)
Srot_0748Secretion protein snm4; KEGG: mpa:MAP3786 hypothetical protein; TIGRFAM: secretion protein snm4; PFAM: protein of unknown function DUF571. (498 aa)
Srot_0785KEGG: nfa:nfa42700 hypothetical protein; Belongs to the WXG100 family. (97 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (346 aa)
lexATranscriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (289 aa)
Srot_0964KEGG: mjl:Mjls_2177 hypothetical protein. (210 aa)
Srot_1012KEGG: rha:RHA1_ro01291 ComEC operon protein; TIGRFAM: ComEC/Rec2-related protein; PFAM: ComEC/Rec2-related protein. (530 aa)
Srot_1053KEGG: nfa:nfa17040 hypothetical protein. (226 aa)
Srot_1076KEGG: nfa:nfa17550 hypothetical protein. (153 aa)
Srot_1100KEGG: mav:MAV_4643 hypothetical protein. (96 aa)
Srot_1173TIGRFAM: DNA-cytosine methyltransferase; KEGG: bgl:bglu_1g01510 DNA cytosine methyltransferase M.NgoMIII; PFAM: C-5 cytosine-specific DNA methylase. (372 aa)
Srot_1306KEGG: mag:amb2067 SOS-response transcriptional repressors. (108 aa)
Srot_1307PFAM: UMUC domain protein DNA-repair protein; KEGG: hha:Hhal_1279 DNA-directed DNA polymerase. (414 aa)
Srot_1315PFAM: Siderophore-interacting protein; FAD-binding 9 siderophore-interacting domain protein; KEGG: rer:RER_17020 siderophore-interacting protein. (273 aa)
Srot_1353KEGG: gbr:Gbro_0534 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (393 aa)
Srot_1382KEGG: nfa:nfa14650 hypothetical protein. (213 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
Srot_1451Putative F420-dependent enzyme; KEGG: mpa:MAP2229 hypothetical protein; TIGRFAM: putative F420-dependent enzyme; PFAM: pyridoxamine 5'-phosphate oxidase-related FMN- binding. (143 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (804 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (954 aa)
Srot_2049PFAM: Mammalian cell entry related domain protein; KEGG: mab:MAB_4030 putative Mce family protein. (422 aa)
Srot_2060KEGG: rha:RHA1_ro04819 hypothetical protein. (152 aa)
Srot_2189PFAM: carbon starvation protein CstA; KEGG: mab:MAB_1260c carbon starvation protein (CstA). (752 aa)
Srot_2366PFAM: heat shock protein Hsp20; KEGG: sen:SACE_2438 small heat shock protein; Belongs to the small heat shock protein (HSP20) family. (135 aa)
Srot_2427DEAD/H associated domain protein; KEGG: mkm:Mkms_1284 DEAD/DEAH box helicase domain- containing protein; PFAM: DEAD/H associated domain protein; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (1495 aa)
Srot_2430KEGG: mab:MAB_2262c ABC transporter ATP-binding protein; PFAM: ABC transporter related; FAD-binding 9 siderophore-interacting domain protein; Siderophore- interacting protein; ABC transporter transmembrane region; SMART: AAA ATPase. (866 aa)
Srot_2438PFAM: PPE protein; KEGG: mjl:Mjls_0363 PPE protein. (492 aa)
Srot_2455Putative F420-dependent enzyme; KEGG: msm:MSMEG_3380 pyridoxamine 5'-phosphate oxidase-related, FMN-binding; TIGRFAM: putative F420-dependent enzyme; PFAM: pyridoxamine 5'-phosphate oxidase-related FMN- binding. (129 aa)
Srot_2459KEGG: saq:Sare_3100 hypothetical protein. (159 aa)
Srot_2494PFAM: protein of unknown function DUF909; KEGG: cgt:cgR_0698 hypothetical protein; Belongs to the WXG100 family. (96 aa)
Srot_2496PFAM: PPE protein; KEGG: msm:MSMEG_0064 PPE family protein. (487 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (451 aa)
Srot_2612KEGG: rer:RER_41290 ABC transporter ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase. (389 aa)
Srot_2684Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (545 aa)
Srot_2745Restriction endonuclease S subunits-like protein; KEGG: mgi:Mflv_0804 restriction modification system DNA specificity subunit. (449 aa)
Srot_2757PFAM: aminoglycoside phosphotransferase; KEGG: mxa:MXAN_5897 phosphotransferase enzyme family protein. (351 aa)
Srot_2805KEGG: nfa:nfa42700 hypothetical protein; Belongs to the WXG100 family. (99 aa)
Srot_2840UBA/THIF-type NAD/FAD binding protein; KEGG: mpa:MAP3306c molybdopterin biosynthesis-like protein MoeZ; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; Rhodanese domain protein; SMART: Rhodanese domain protein. (431 aa)
Srot_2949KEGG: nfa:nfa42700 hypothetical protein; Belongs to the WXG100 family. (95 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (248 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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