STRINGSTRING
Srot_0710 Srot_0710 rpoC rpoC glmU glmU prs prs Srot_2675 Srot_2675 pyrH pyrH Srot_2642 Srot_2642 Srot_2600 Srot_2600 coaA coaA dinB dinB purL purL pyrG pyrG rpoA rpoA ackA ackA Srot_2348 Srot_2348 tgt tgt Srot_2335 Srot_2335 nusB nusB pyrB pyrB pyrC pyrC Srot_2314 Srot_2314 carA carA carB carB Srot_2298 Srot_2298 gmk gmk rpoZ rpoZ Srot_2294 Srot_2294 priA priA Srot_2262 Srot_2262 Srot_2216 Srot_2216 Srot_2198 Srot_2198 Srot_2151 Srot_2151 Srot_2092 Srot_2092 Srot_2080 Srot_2080 Srot_2001 Srot_2001 thyA thyA folD folD nusA nusA Srot_1823 Srot_1823 dnaG dnaG ndk ndk Srot_1656 Srot_1656 purA purA pyrE pyrE Srot_1609 Srot_1609 Srot_1607 Srot_1607 Srot_1584 Srot_1584 Srot_1578 Srot_1578 nadK nadK Srot_1514 Srot_1514 purH purH purN purN Srot_1457 Srot_1457 apt apt Srot_1432 Srot_1432 Srot_1415 Srot_1415 Srot_1350 Srot_1350 Srot_1349 Srot_1349 Srot_1307 Srot_1307 cmk cmk Srot_1287 Srot_1287 nadE nadE Srot_1228 Srot_1228 dcd dcd pyrD pyrD Srot_1118 Srot_1118 nadD nadD dut dut sigA sigA Srot_0957 Srot_0957 Srot_0931 Srot_0931 Srot_0889 Srot_0889 dnaX dnaX Srot_0876 Srot_0876 guaA guaA Srot_0806 Srot_0806 rpoB rpoB Srot_0709 Srot_0709 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF-2 atpF-2 atpF atpF atpE atpE atpB atpB rho rho coaE coaE Srot_0636 Srot_0636 Srot_0632 Srot_0632 Srot_0605 Srot_0605 Srot_0578 Srot_0578 Srot_0470 Srot_0470 purD purD Srot_0445 Srot_0445 coaX coaX Srot_0399 Srot_0399 Srot_0285 Srot_0285 purC purC Srot_0234 Srot_0234 Srot_0166 Srot_0166 Srot_0145 Srot_0145 Srot_0021 Srot_0021 Srot_0012 Srot_0012 Srot_0006 Srot_0006 Srot_0002 Srot_0002 Srot_3055 Srot_3055 purF purF purM purM purQ purQ purS purS purK purK purE purE upp upp Srot_2941 Srot_2941 guaB guaB Srot_2919 Srot_2919 adk adk Srot_2868 Srot_2868 polA polA coaD coaD nusG nusG
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Srot_0710TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: msm:MSMEG_3201 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (293 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1325 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (492 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
Srot_2675dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (294 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (249 aa)
Srot_2642KEGG: rer:RER_35140 hypothetical protein. (137 aa)
Srot_2600Adenylate/guanylate cyclase with integral membrane sensor; KEGG: gbr:Gbro_0577 adenylyl cyclase class- 3/4/guanylyl cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; SMART: histidine kinase HAMP region domain protein; adenylyl cyclase class-3/4/guanylyl cyclase. (516 aa)
coaATIGRFAM: pantothenate kinase; KEGG: nfa:nfa48170 pantothenate kinase. (323 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (451 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (757 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (563 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (350 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (371 aa)
Srot_2348KEGG: saq:Sare_3780 P4 family phage/plasmid primase; TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4; Bifunctional DNA primase/polymerase. (761 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (411 aa)
Srot_2335KEGG: rop:ROP_51690 hypothetical protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (337 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (157 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; KEGG: rer:RER_30000 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (324 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa)
Srot_2314KEGG: nfa:nfa36210 hypothetical protein. (173 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: mav:MAV_3390 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (376 aa)
carBKEGG: nfa:nfa36190 carbamoyl phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1119 aa)
Srot_2298TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: ami:Amir_5240 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa)
rpoZDNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (89 aa)
Srot_2294Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (415 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (652 aa)
Srot_2262KEGG: mva:Mvan_1364 dTDP-4-dehydrorhamnose 3,5- epimerase; PFAM: dTDP-4-dehydrorhamnose 35-epimerase related. (199 aa)
Srot_2216PFAM: thymidylate kinase; KEGG: mav:MAV_4210 thymidylate kinase. (209 aa)
Srot_2198RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: rop:ROP_64020 RNA polymerase ECF-type sigma factor SigH; TIGRFAM: RNA polymerase sigma-70 factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (256 aa)
Srot_2151TIGRFAM: adenosine deaminase; KEGG: gbr:Gbro_1781 adenosine deaminase; PFAM: adenosine/AMP deaminase. (383 aa)
Srot_2092RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: mav:MAV_1365 RNA polymerase sigma-70 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (226 aa)
Srot_2080Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (239 aa)
Srot_2001Riboflavin biosynthesis protein RibF; KEGG: rop:ROP_66920 flavokinase/FAD synthetase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (323 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (270 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
nusATranscription termination factor NusA; Participates in both transcription termination and antitermination. (342 aa)
Srot_1823PFAM: isochorismatase hydrolase; KEGG: mgi:Mflv_1089 isochorismatase hydrolase. (186 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (619 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
Srot_1656RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: rer:RER_52370 RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (166 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (181 aa)
Srot_1609KEGG: mab:MAB_4264c hypothetical protein. (381 aa)
Srot_1607PFAM: Oxidoreductase FAD-binding domain protein; globin; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gbr:Gbro_4265 oxidoreductase FAD/NAD(P)- binding domain protein. (371 aa)
Srot_1584KEGG: rop:ROP_19940 hypothetical membrane protein. (134 aa)
Srot_1578Dihydropyrimidinase; KEGG: bcv:Bcav_2578 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (472 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (315 aa)
Srot_1514Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (447 aa)
purHSMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: nfa:nfa49860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (526 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
Srot_1457(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (797 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
Srot_1432TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mab:MAB_2696c DNA polymerase III subunit alpha; SMART: phosphoesterase PHP domain protein. (1179 aa)
Srot_1415KEGG: saq:Sare_1212 putative phiRv2 prophage protein. (373 aa)
Srot_1350Hypothetical protein; KEGG: car:cauri_0673 thymidylate kinase. (281 aa)
Srot_1349PFAM: thymidylate kinase; KEGG: sdn:Sden_1167 thymidylate kinase-like protein. (205 aa)
Srot_1307PFAM: UMUC domain protein DNA-repair protein; KEGG: hha:Hhal_1279 DNA-directed DNA polymerase. (414 aa)
cmkKEGG: rha:RHA1_ro00924 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (230 aa)
Srot_1287Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (334 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (282 aa)
Srot_1228TIGRFAM: nucleotide sugar dehydrogenase; KEGG: rop:ROP_55250 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP- glucose/GDP-mannose dehydrogenase dimerisation; UDP- glucose/GDP-mannose dehydrogenase. (443 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (200 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (352 aa)
Srot_1118acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (647 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa)
sigARNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (441 aa)
Srot_0957RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (377 aa)
Srot_0931PFAM: CinA domain protein; KEGG: rop:ROP_67410 hypothetical protein; Belongs to the CinA family. (169 aa)
Srot_0889KEGG: bfa:Bfae_16880 hypothetical protein. (494 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (664 aa)
Srot_0876Hypothetical protein; KEGG: sgr:SGR_6234 putative phosphotransferase. (221 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (525 aa)
Srot_0806KEGG: pol:Bpro_1315 phage/plasmid primase P4-like; TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4. (633 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1175 aa)
Srot_0709Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (357 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (123 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (482 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (329 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (543 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (282 aa)
atpF-2H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (174 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (91 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (253 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (614 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (410 aa)
Srot_0636Adenylate/guanylate cyclase with integral membrane sensor; KEGG: rop:ROP_11720 adenylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; SMART: histidine kinase HAMP region domain protein; adenylyl cyclase class-3/4/guanylyl cyclase. (519 aa)
Srot_0632TIGRFAM: mannose-6-phosphate isomerase, class I; KEGG: mab:MAB_3601c mannose-6-phosphate isomerase ManA; PFAM: mannose-6-phosphate isomerase type I. (391 aa)
Srot_0605TIGRFAM: seryl-tRNA synthetase; KEGG: sma:SAV_2294 seryl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Seryl- tRNA synthetase, class IIa-like. (423 aa)
Srot_0578KEGG: nfa:nfa10720 hypothetical protein. (103 aa)
Srot_0470PFAM: DNA polymerase III delta; KEGG: rha:RHA1_ro01286 DNA polymerase III delta subunit. (333 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; KEGG: rop:ROP_48670 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (420 aa)
Srot_0445PFAM: transcription factor CarD; KEGG: mmi:MMAR_5083 transcriptional regulatory protein. (162 aa)
coaXTranscriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa)
Srot_0399TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: mjl:Mjls_5161 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (201 aa)
Srot_0285Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (485 aa)
purCTIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; KEGG: rha:RHA1_ro04817 phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (295 aa)
Srot_0234SMART: AAA ATPase; KEGG: nfa:nfa3680 DNA polymerase III subunit delta'. (385 aa)
Srot_0166KEGG: mmi:MMAR_0265 ECF subfamily RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (206 aa)
Srot_0145TIGRFAM: adenylosuccinate lyase; KEGG: rop:ROP_48780 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
Srot_0021RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: mva:Mvan_4927 RNA polymerase sigma factor SigK; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (215 aa)
Srot_0012KEGG: saq:Sare_5095 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (202 aa)
Srot_0006PFAM: protein of unknown function DUF179; KEGG: mbt:JTY_0039 hypothetical protein; Belongs to the UPF0301 (AlgH) family. (200 aa)
Srot_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (397 aa)
Srot_3055Domain of unknown function DUF1794; May play a role in the intracellular transport of hydrophobic ligands. (205 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (503 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; KEGG: mab:MAB_0728 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (358 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (225 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (181 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
Srot_2941KEGG: rer:RER_19340 hypothetical protein; TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase. (382 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (512 aa)
Srot_2919PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: rop:ROP_51450 adenylate cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (371 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (182 aa)
Srot_2868RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: mab:MAB_1248 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (903 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
nusGNusG antitermination factor; Participates in transcription elongation, termination and antitermination. (258 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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