STRINGSTRING
Srot_0185 Srot_0185 mdh mdh Srot_0804 Srot_0804 Srot_1302 Srot_1302 Srot_1311 Srot_1311 Srot_1317 Srot_1317 Srot_1473 Srot_1473 sucC sucC sucD sucD mqo mqo Srot_1886 Srot_1886 Srot_1984 Srot_1984 Srot_2097 Srot_2097 Srot_2154 Srot_2154 Srot_2155 Srot_2155 Srot_2156 Srot_2156 Srot_2157 Srot_2157 fumC fumC Srot_2734 Srot_2734 pckG pckG Srot_2884 Srot_2884
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Srot_0185TIGRFAM: citrate synthase I; KEGG: rha:RHA1_ro04998 type II citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (442 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (336 aa)
Srot_0804Hypothetical protein; KEGG: cli:Clim_1716 STE24 endopeptidase. (102 aa)
Srot_1302Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1127 aa)
Srot_1311TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: mtb:TBMG_00066 isocitrate dehydrogenase [NADP] icd2; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (745 aa)
Srot_1317PFAM: Transketolase domain protein; Transketolase central region; KEGG: rop:ROP_72230 putative pyruvate dehydrogenase E1 component. (772 aa)
Srot_1473Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (935 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa)
mqoTIGRFAM: malate/quinone oxidoreductase; KEGG: rer:RER_26040 malate--quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase. (505 aa)
Srot_1886TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: rha:RHA1_ro06238 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
Srot_1984KEGG: mab:MAB_4127c dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (466 aa)
Srot_2097KEGG: nfa:nfa16900 dihydrolipoamide acetyltransferase; TIGRFAM: 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein. (585 aa)
Srot_2154KEGG: mab:MAB_3673 succinate dehydrogenase (cytochrome b-556 subunit) SdhC; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit. (126 aa)
Srot_2155KEGG: mjl:Mjls_1255 succinate dehydrogenase subunit D. (139 aa)
Srot_2156KEGG: rha:RHA1_ro06246 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (585 aa)
Srot_2157KEGG: rop:ROP_63040 succinate dehydrogenase iron- sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (267 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (472 aa)
Srot_27342-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (617 aa)
Srot_2884TIGRFAM: 2-methylcitrate synthase/citrate synthase II; KEGG: rer:RER_50290 2-methylcitrate synthase/citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (382 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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