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dut dut pyrD pyrD dcd dcd Srot_1286 Srot_1286 Srot_1287 Srot_1287 cmk cmk Srot_1349 Srot_1349 Srot_1578 Srot_1578 pyrE pyrE ndk ndk thyA thyA Srot_2152 Srot_2152 Srot_2153 Srot_2153 Srot_2216 Srot_2216 Srot_2298 Srot_2298 carB carB carA carA pyrC pyrC pyrB pyrB pyrR pyrR Srot_2484 Srot_2484 pyrG pyrG pyrH pyrH Srot_2668 Srot_2668 Srot_2913 Srot_2913 upp upp
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (352 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (200 aa)
Srot_1286Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (732 aa)
Srot_1287Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (334 aa)
cmkKEGG: rha:RHA1_ro00924 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (230 aa)
Srot_1349PFAM: thymidylate kinase; KEGG: sdn:Sden_1167 thymidylate kinase-like protein. (205 aa)
Srot_1578Dihydropyrimidinase; KEGG: bcv:Bcav_2578 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (472 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (181 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (270 aa)
Srot_2152TIGRFAM: pyrimidine-nucleoside phosphorylase; KEGG: nca:Noca_3535 thymidine phosphorylase; PFAM: glycosyl transferase family 3; Glycosyl transferase, family 3-like; Pyrimidine nucleoside phosphorylase domain. (466 aa)
Srot_2153PFAM: CMP/dCMP deaminase zinc-binding; KEGG: mmi:MMAR_1204 cytidine deaminase. (135 aa)
Srot_2216PFAM: thymidylate kinase; KEGG: mav:MAV_4210 thymidylate kinase. (209 aa)
Srot_2298TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: ami:Amir_5240 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa)
carBKEGG: nfa:nfa36190 carbamoyl phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1119 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: mav:MAV_3390 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (376 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; KEGG: rer:RER_30000 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (324 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (215 aa)
Srot_2484TIGRFAM: amidase, hydantoinase/carbamoylase family; KEGG: rop:ROP_25390 peptidase M20 family protein; PFAM: peptidase M20. (408 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (563 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (249 aa)
Srot_2668Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
Srot_2913TIGRFAM: amidase, hydantoinase/carbamoylase family; KEGG: aau:AAur_0749 putative N-carbamoyl-L-amino acid amidohydrolase; PFAM: peptidase M20. (415 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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