STRINGSTRING
Srot_0106 Srot_0106 serC serC Srot_0301 Srot_0301 Srot_0302 Srot_0302 Srot_0520 Srot_0520 mdh mdh Srot_0682 Srot_0682 Srot_0777 Srot_0777 Srot_1051 Srot_1051 Srot_1173 Srot_1173 Srot_1282 Srot_1282 Srot_1353 Srot_1353 metZ metZ Srot_1887 Srot_1887 metXA metXA Srot_1909 Srot_1909 Srot_1979 Srot_1979 Srot_1980 Srot_1980 Srot_2032 Srot_2032 Srot_2054 Srot_2054 speH speH speE speE ahcY ahcY metK metK Srot_2440 Srot_2440 Srot_2618 Srot_2618 asd asd metE metE Srot_3052 Srot_3052
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Srot_0106KEGG: npu:Npun_R6310 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase. (314 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
Srot_0301TIGRFAM: serine O-acetyltransferase; KEGG: rer:RER_10920 serine acetyltransferase. (194 aa)
Srot_0302KEGG: rer:RER_10910 cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
Srot_0520Rhodanese domain protein; KEGG: rer:RER_21240 thiosulfate sulfurtransferase; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (336 aa)
Srot_0682KEGG: mav:MAV_1509 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (471 aa)
Srot_0777PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: nfa:nfa48640 hypothetical protein. (350 aa)
Srot_1051KEGG: msm:MSMEG_4276 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (370 aa)
Srot_1173TIGRFAM: DNA-cytosine methyltransferase; KEGG: bgl:bglu_1g01510 DNA cytosine methyltransferase M.NgoMIII; PFAM: C-5 cytosine-specific DNA methylase. (372 aa)
Srot_1282PFAM: purine or other phosphorylase family 1; KEGG: rop:ROP_64870 hypothetical protein. (188 aa)
Srot_1353KEGG: gbr:Gbro_0534 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (393 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (410 aa)
Srot_1887TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: msm:MSMEG_1652 O-acetylhomoserine aminocarboxypropyltransferase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein. (434 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (380 aa)
Srot_19095-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (770 aa)
Srot_1979KEGG: mav:MAV_1203 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein. (386 aa)
Srot_1980KEGG: mab:MAB_1195 cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein. (461 aa)
Srot_2032PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: msm:MSMEG_2394 cystathionine gamma-lyase. (373 aa)
Srot_2054KEGG: mav:MAV_3847 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (531 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (126 aa)
speESpermine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (296 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (490 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (404 aa)
Srot_2440PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ami:Amir_4781 pyridoxal-5'-phosphate- dependent protein beta subunit. (348 aa)
Srot_2618KEGG: rha:RHA1_ro04291 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
metE5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (755 aa)
Srot_3052Thiosulfate sulfurtransferase; PFAM: Rhodanese domain protein; KEGG: gbr:Gbro_3937 thiosulfate sulfurtransferase; SMART: Rhodanese domain protein. (277 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.