STRINGSTRING
Srot_0314 Srot_0314 Srot_0519 Srot_0519 Srot_0579 Srot_0579 Srot_0673 Srot_0673 Srot_1118 Srot_1118 Srot_1335 Srot_1335 sucC sucC sucD sucD Srot_1984 Srot_1984 Srot_2079 Srot_2079 Srot_2160 Srot_2160 ackA ackA Srot_2410 Srot_2410 Srot_2412 Srot_2412 Srot_2424 Srot_2424 Srot_2536 Srot_2536 Srot_2537 Srot_2537 Srot_2824 Srot_2824 Srot_2885 Srot_2885 Srot_2980 Srot_2980
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Srot_0314PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nfa:nfa32360 enoyl-CoA hydratase. (349 aa)
Srot_0519PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; KEGG: mgi:Mflv_4784 carbamoyl-phosphate synthase L chain, ATP-binding. (596 aa)
Srot_0579TIGRFAM: acetyl-CoA acetyltransferase; KEGG: rer:RER_38940 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Srot_0673KEGG: sgr:SGR_1215 putative NAD-dependent aldehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. (509 aa)
Srot_1118acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (647 aa)
Srot_1335KEGG: nca:Noca_3205 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa)
Srot_1984KEGG: mab:MAB_4127c dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (466 aa)
Srot_2079PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nca:Noca_0288 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
Srot_2160KEGG: rop:ROP_52500 acetyl-CoA acyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (449 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (371 aa)
Srot_2410PFAM: Enoyl-CoA hydratase/isomerase; KEGG: cai:Caci_4435 enoyl-CoA hydratase/isomerase. (254 aa)
Srot_2412PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; KEGG: rer:RER_17550 acyl-CoA carboxylase alpha chain. (680 aa)
Srot_24242-methylcitrate dehydratase; KEGG: cgb:cg2796 MmgE/PrpD family protein; PFAM: MmgE/PrpD family protein. (474 aa)
Srot_2536PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: svi:Svir_30240 short chain enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. (719 aa)
Srot_2537KEGG: gbr:Gbro_4504 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
Srot_2824PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mjl:Mjls_4812 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (242 aa)
Srot_2885KEGG: rop:ROP_30470 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein. (495 aa)
Srot_2980PFAM: carboxyl transferase; KEGG: gbr:Gbro_1840 carboxyl transferase. (540 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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