STRINGSTRING
serC serC Srot_0185 Srot_0185 Srot_0301 Srot_0301 Srot_0302 Srot_0302 pgl pgl zwf zwf tal tal Srot_0467 Srot_0467 Srot_0519 Srot_0519 mdh mdh Srot_0579 Srot_0579 Srot_0616 Srot_0616 pgk pgk tpiA tpiA ppc ppc Srot_0673 Srot_0673 Srot_0804 Srot_0804 Srot_0962 Srot_0962 Srot_1072 Srot_1072 Srot_1082 Srot_1082 Srot_1096 Srot_1096 Srot_1118 Srot_1118 Srot_1131 Srot_1131 pfkA pfkA Srot_1302 Srot_1302 Srot_1311 Srot_1311 Srot_1317 Srot_1317 Srot_1367 Srot_1367 Srot_1473 Srot_1473 sucC sucC sucD sucD eno eno Srot_1615 Srot_1615 Srot_1653 Srot_1653 Srot_1784 Srot_1784 glcB glcB gpmA gpmA mqo mqo Srot_1882 Srot_1882 Srot_1886 Srot_1886 folD folD Srot_1899 Srot_1899 Srot_1910 Srot_1910 Srot_1911 Srot_1911 Srot_1984 Srot_1984 Srot_2054 Srot_2054 Srot_2057 Srot_2057 gcvT gcvT Srot_2097 Srot_2097 Srot_2154 Srot_2154 Srot_2155 Srot_2155 Srot_2156 Srot_2156 Srot_2157 Srot_2157 Srot_2160 Srot_2160 gcvP gcvP gcvH gcvH ackA ackA Srot_2412 Srot_2412 Srot_2440 Srot_2440 Srot_2523 Srot_2523 Srot_2536 Srot_2536 Srot_2537 Srot_2537 Srot_2559 Srot_2559 fumC fumC glyA glyA Srot_2624 Srot_2624 pgi pgi Srot_2654 Srot_2654 prs prs Srot_2734 Srot_2734 Srot_2884 Srot_2884 Srot_2980 Srot_2980
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
Srot_0185TIGRFAM: citrate synthase I; KEGG: rha:RHA1_ro04998 type II citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (442 aa)
Srot_0301TIGRFAM: serine O-acetyltransferase; KEGG: rer:RER_10920 serine acetyltransferase. (194 aa)
Srot_0302KEGG: rer:RER_10910 cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (235 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (515 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa)
Srot_0467Transketolase; KEGG: mab:MAB_2759 transketolase; TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase central region; Belongs to the transketolase family. (714 aa)
Srot_0519PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; KEGG: mgi:Mflv_4784 carbamoyl-phosphate synthase L chain, ATP-binding. (596 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (336 aa)
Srot_0579TIGRFAM: acetyl-CoA acetyltransferase; KEGG: rer:RER_38940 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Srot_0616TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: nfa:nfa35890 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
pgkKEGG: mgi:Mflv_3709 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (408 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (264 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (930 aa)
Srot_0673KEGG: sgr:SGR_1215 putative NAD-dependent aldehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. (509 aa)
Srot_0804Hypothetical protein; KEGG: cli:Clim_1716 STE24 endopeptidase. (102 aa)
Srot_0962PFAM: ROK family protein; KEGG: nfa:nfa37580 putative polyphosphate glucokinase. (272 aa)
Srot_1072KEGG: rha:RHA1_ro01105 5,10- methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (336 aa)
Srot_1082TIGRFAM: fructose-1,6-bisphosphatase, class II; KEGG: rop:ROP_59270 fructose 1,6-bisphosphatase class II; PFAM: GlpX family protein. (340 aa)
Srot_1096KEGG: pgi:PG0690 4-hydroxybutyrate CoA-transferase. (429 aa)
Srot_1118acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (647 aa)
Srot_1131KEGG: rha:RHA1_ro01065 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Threonine dehydratase domain protein. (443 aa)
pfkAPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (344 aa)
Srot_1302Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1127 aa)
Srot_1311TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: mtb:TBMG_00066 isocitrate dehydrogenase [NADP] icd2; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (745 aa)
Srot_1317PFAM: Transketolase domain protein; Transketolase central region; KEGG: rop:ROP_72230 putative pyruvate dehydrogenase E1 component. (772 aa)
Srot_1367TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); KEGG: nfa:nfa42930 putative phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (420 aa)
Srot_1473Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (935 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
Srot_1615Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
Srot_1653KEGG: mab:MAB_1199 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (403 aa)
Srot_17846-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (726 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (250 aa)
mqoTIGRFAM: malate/quinone oxidoreductase; KEGG: rer:RER_26040 malate--quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase. (505 aa)
Srot_1882D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (397 aa)
Srot_1886TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: rha:RHA1_ro06238 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
Srot_1899TIGRFAM: ribose 5-phosphate isomerase; sugar- phosphate isomerase, RpiB/LacA/LacB family; KEGG: nfa:nfa13270 ribose-5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (154 aa)
Srot_1910KEGG: rha:RHA1_ro02121 3-hydroxybutyryl-CoA dehydrogenase; PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein. (292 aa)
Srot_1911KEGG: mva:Mvan_0801 isocitrate lyase; TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase. (432 aa)
Srot_1984KEGG: mab:MAB_4127c dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (466 aa)
Srot_2054KEGG: mav:MAV_3847 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (531 aa)
Srot_2057TIGRFAM: pyruvate kinase; KEGG: rha:RHA1_ro03221 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (473 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
Srot_2097KEGG: nfa:nfa16900 dihydrolipoamide acetyltransferase; TIGRFAM: 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein. (585 aa)
Srot_2154KEGG: mab:MAB_3673 succinate dehydrogenase (cytochrome b-556 subunit) SdhC; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit. (126 aa)
Srot_2155KEGG: mjl:Mjls_1255 succinate dehydrogenase subunit D. (139 aa)
Srot_2156KEGG: rha:RHA1_ro06246 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (585 aa)
Srot_2157KEGG: rop:ROP_63040 succinate dehydrogenase iron- sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (267 aa)
Srot_2160KEGG: rop:ROP_52500 acetyl-CoA acyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (449 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (140 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (371 aa)
Srot_2412PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; KEGG: rer:RER_17550 acyl-CoA carboxylase alpha chain. (680 aa)
Srot_2440PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ami:Amir_4781 pyridoxal-5'-phosphate- dependent protein beta subunit. (348 aa)
Srot_2523PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: mab:MAB_0759c putative dehydrogenase (3- hydroxybutyryl-CoA dehydrogenase FadB). (286 aa)
Srot_2536PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: svi:Svir_30240 short chain enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. (719 aa)
Srot_2537KEGG: gbr:Gbro_4504 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
Srot_2559Catalase related subgroup; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (352 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (472 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (436 aa)
Srot_2624Catalase; KEGG: mmi:MMAR_5217 catalase KatE; PFAM: Catalase related subgroup; Catalase domain protein. (486 aa)
pgiKEGG: nfa:nfa49980 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (550 aa)
Srot_2654TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: mjl:Mjls_2426 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
Srot_27342-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa)
Srot_2884TIGRFAM: 2-methylcitrate synthase/citrate synthase II; KEGG: rer:RER_50290 2-methylcitrate synthase/citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (382 aa)
Srot_2980PFAM: carboxyl transferase; KEGG: gbr:Gbro_1840 carboxyl transferase. (540 aa)
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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