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cbiX cbiX VNG_1547C VNG_1547C cbiT cbiT cbiL cbiL cbiF cbiF cbiG cbiG cobH cobH cbiH cbiH VNG_1558H VNG_1558H VNG_1559H VNG_1559H VNG_1561C VNG_1561C VNG_1562H VNG_1562H VNG_1564H VNG_1564H cobN cobN cbiC cbiC cbiJ cbiJ cbiX3 cbiX3 VNG_1572C VNG_1572C cbiA cbiA cobI cobI cbiP cbiP VNG_1577C VNG_1577C cbiB cbiB cobS cobS VNG_1581C VNG_1581C hisC2 hisC2 cbiZ cbiZ cbiO2 cbiO2 cbiQ cbiQ cbiN cbiN cbiM cbiM hemA hemA sirC sirC bioY bioY cbiO1 cbiO1 hem2 hem2 hemL hemL hem3 hem3 uroM uroM cysG cysG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cbiXConserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis; Belongs to the CbiX family. CbiXS subfamily. (292 aa)
VNG_1547CConserved hypothetical protein; Vng1547c. (163 aa)
cbiTCobalamin biosynthesis; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (187 aa)
cbiLCobalamin biosynthesis; CbiL; Belongs to the precorrin methyltransferase family. (234 aa)
cbiFCobalamin biosynthesis; CbiF. (288 aa)
cbiGCobalamin biosynthesis; CbiG. (325 aa)
cobHCobalamin biosynthesis; CobH. (276 aa)
cbiHCobalamin biosynthesis; CbiH. (335 aa)
VNG_1558HHypothetical protein; Vng1558h. (82 aa)
VNG_1559HHypothetical protein; Vng1559h. (232 aa)
VNG_1561CConserved hypothetical protein; Vng1561c. (199 aa)
VNG_1562HHypothetical protein; Vng1562h. (123 aa)
VNG_1564HHypothetical protein; Vng1564h. (407 aa)
cobNCobalamin biosynthesis protein; CobN. (1234 aa)
cbiCPrecorrin isomerase; CbiC. (237 aa)
cbiJPrecorrin-3 methylase; CbiJ. (250 aa)
cbiX3Hypothetical protein; Vng1570h. (256 aa)
VNG_1572CConserved hypothetical protein; Vng1572c; Belongs to the UPF0284 family. (300 aa)
cbiACobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (441 aa)
cobICobalamin adenosyltransferase; CobI. (225 aa)
cbiPCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (512 aa)
VNG_1577CConserved hypothetical protein; Vng1577c. (152 aa)
cbiBHypothetical protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (308 aa)
cobSHypothetical protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (199 aa)
VNG_1581CConserved hypothetical protein; Vng1581c. (189 aa)
hisC2Histidinol-phosphate transaminase; HisC2. (336 aa)
cbiZConserved hypothetical protein; Converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route. (231 aa)
cbiO2Cobalt transport ATP-binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (242 aa)
cbiQCobalt transport protein; CbiQ. (242 aa)
cbiNCobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (96 aa)
cbiMCobalamin biosynthesis protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (220 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa)
sirCConserved hypothetical protein; Vng1775c. (220 aa)
bioYConserved hypothetical protein; Vng2316c. (202 aa)
cbiO1Cobalt transport ATP-binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (232 aa)
hem2Porphobilinogen synthase; Hem2; Belongs to the ALAD family. (326 aa)
hemLGlutamate-1-semialdehyde aminotransferase; HemL; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (445 aa)
hem3Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (396 aa)
uroMS-adenosyl-L-methionine:uroporphyrinogen III methyltransferase; UroM; Belongs to the precorrin methyltransferase family. (246 aa)
cysGuroporphyrin-III C-methyltransferase; CysG. (207 aa)
Your Current Organism:
Halobacterium salinarum
NCBI taxonomy Id: 64091
Other names: H. salinarum NRC-1, Halobacterium halobium NRC-1, Halobacterium salinarum NRC-1, Halobacterium salinarum str. NRC-1, Halobacterium salinarum strain NRC-1, Halobacterium sp. (strain NRC-1 / ATCC 700922 / JCM 11081), Halobacterium sp. (strain NRC-1), Halobacterium sp. ATCC 700922, Halobacterium sp. JCM 11081, Halobacterium sp. NRC-1
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