(13 nodes) Presynaptic depolarization and calcium channel opening, and Voltage-dependent calcium channel, alpha-1 subunit, IQ domain network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1EGM4_HELRO	Uncharacterized protein. (1408 aa)
	T1EHR1_HELRO	Uncharacterized protein. (1602 aa)
	T1EHR3_HELRO	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1563 aa)
	T1EIC6_HELRO	VWA_N domain-containing protein. (111 aa)
	T1EJ14_HELRO	GuKc domain-containing protein. (362 aa)
	T1ELX5_HELRO	Ion_trans domain-containing protein. (82 aa)
	T1F370_HELRO	Uncharacterized protein. (182 aa)
	T1F8P7_HELRO	VWFA domain-containing protein. (956 aa)
	T1FPX9_HELRO	SH3 domain-containing protein. (922 aa)
	T1FZ15_HELRO	VWFA domain-containing protein. (418 aa)
	T1G1F3_HELRO	Ca_chan_IQ domain-containing protein. (1418 aa)
	T1G3A9_HELRO	GuKc domain-containing protein. (415 aa)
	T1G4G2_HELRO	GuKc domain-containing protein. (397 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EGM4_HELRO	T1EHR1_HELRO	T1EGM4	T1EHR1	Uncharacterized protein.	Uncharacterized protein.	0.546
T1EGM4_HELRO	T1EHR3_HELRO	T1EGM4	T1EHR3	Uncharacterized protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.555
T1EGM4_HELRO	T1EIC6_HELRO	T1EGM4	T1EIC6	Uncharacterized protein.	VWA_N domain-containing protein.	0.694
T1EGM4_HELRO	T1EJ14_HELRO	T1EGM4	T1EJ14	Uncharacterized protein.	GuKc domain-containing protein.	0.759
T1EGM4_HELRO	T1ELX5_HELRO	T1EGM4	T1ELX5	Uncharacterized protein.	Ion_trans domain-containing protein.	0.543
T1EGM4_HELRO	T1F370_HELRO	T1EGM4	T1F370	Uncharacterized protein.	Uncharacterized protein.	0.694
T1EGM4_HELRO	T1F8P7_HELRO	T1EGM4	T1F8P7	Uncharacterized protein.	VWFA domain-containing protein.	0.694
T1EGM4_HELRO	T1FPX9_HELRO	T1EGM4	T1FPX9	Uncharacterized protein.	SH3 domain-containing protein.	0.759
T1EGM4_HELRO	T1FZ15_HELRO	T1EGM4	T1FZ15	Uncharacterized protein.	VWFA domain-containing protein.	0.694
T1EGM4_HELRO	T1G1F3_HELRO	T1EGM4	T1G1F3	Uncharacterized protein.	Ca_chan_IQ domain-containing protein.	0.547
T1EGM4_HELRO	T1G3A9_HELRO	T1EGM4	T1G3A9	Uncharacterized protein.	GuKc domain-containing protein.	0.759
T1EGM4_HELRO	T1G4G2_HELRO	T1EGM4	T1G4G2	Uncharacterized protein.	GuKc domain-containing protein.	0.759
T1EHR1_HELRO	T1EGM4_HELRO	T1EHR1	T1EGM4	Uncharacterized protein.	Uncharacterized protein.	0.546
T1EHR1_HELRO	T1EHR3_HELRO	T1EHR1	T1EHR3	Uncharacterized protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.559
T1EHR1_HELRO	T1EIC6_HELRO	T1EHR1	T1EIC6	Uncharacterized protein.	VWA_N domain-containing protein.	0.694
T1EHR1_HELRO	T1EJ14_HELRO	T1EHR1	T1EJ14	Uncharacterized protein.	GuKc domain-containing protein.	0.759
T1EHR1_HELRO	T1ELX5_HELRO	T1EHR1	T1ELX5	Uncharacterized protein.	Ion_trans domain-containing protein.	0.542
T1EHR1_HELRO	T1F370_HELRO	T1EHR1	T1F370	Uncharacterized protein.	Uncharacterized protein.	0.694
T1EHR1_HELRO	T1F8P7_HELRO	T1EHR1	T1F8P7	Uncharacterized protein.	VWFA domain-containing protein.	0.694
T1EHR1_HELRO	T1FPX9_HELRO	T1EHR1	T1FPX9	Uncharacterized protein.	SH3 domain-containing protein.	0.759