(25 nodes) Cyclin-dependent protein kinase holoenzyme complex, and Cyclin-dependent protein kinase activity network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdc25	Hro-Cdc25. (422 aa)
	T1EE28_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (367 aa)
	T1EE44_HELRO	Protein kinase domain-containing protein. (539 aa)
	T1EEQ9_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (404 aa)
	T1EFI3_HELRO	Uncharacterized protein. (512 aa)
	T1EGC7_HELRO	Cyclin A; Belongs to the cyclin family. (430 aa)
	T1F2J4_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (254 aa)
	T1F4Z9_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (287 aa)
	T1F8N9_HELRO	Uncharacterized protein. (353 aa)
	T1FJT8_HELRO	Cyclin_C domain-containing protein. (134 aa)
	T1FM95_HELRO	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (82 aa)
	T1FNH6_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa)
	T1FNQ9_HELRO	Uncharacterized protein; Belongs to the cyclin family. (511 aa)
	T1FP29_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa)
	T1FR06_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (358 aa)
	T1FX52_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
	T1FZE6_HELRO	Uncharacterized protein; Belongs to the cyclin family. (339 aa)
	T1G3J2_HELRO	Uncharacterized protein. (142 aa)
	T1G3W7_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
	T1G597_HELRO	Rhodanese domain-containing protein. (414 aa)
	T1G650_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (182 aa)
	T1G7J9_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (268 aa)
	T1G8G9_HELRO	Cyclin_C domain-containing protein. (178 aa)
	T1G971_HELRO	Uncharacterized protein; Belongs to the cyclin family. (361 aa)
	T1G9H1_HELRO	Protein kinase domain-containing protein. (271 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EE28_HELRO	T1EE44_HELRO	T1EE28	T1EE44	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.826
T1EE28_HELRO	T1EEQ9_HELRO	T1EE28	T1EEQ9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.585
T1EE28_HELRO	T1EFI3_HELRO	T1EE28	T1EFI3	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.766
T1EE28_HELRO	T1EGC7_HELRO	T1EE28	T1EGC7	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin A; Belongs to the cyclin family.	0.805
T1EE28_HELRO	T1F2J4_HELRO	T1EE28	T1F2J4	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.603
T1EE28_HELRO	T1F4Z9_HELRO	T1EE28	T1F4Z9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.772
T1EE28_HELRO	T1FJT8_HELRO	T1EE28	T1FJT8	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin_C domain-containing protein.	0.546
T1EE28_HELRO	T1FM95_HELRO	T1EE28	T1FM95	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.869
T1EE28_HELRO	T1FNH6_HELRO	T1EE28	T1FNH6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.772
T1EE28_HELRO	T1FNQ9_HELRO	T1EE28	T1FNQ9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the cyclin family.	0.904
T1EE28_HELRO	T1FP29_HELRO	T1EE28	T1FP29	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.772
T1EE28_HELRO	T1FX52_HELRO	T1EE28	T1FX52	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.826
T1EE28_HELRO	T1G3J2_HELRO	T1EE28	T1G3J2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.635
T1EE28_HELRO	T1G3W7_HELRO	T1EE28	T1G3W7	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.752
T1EE28_HELRO	T1G597_HELRO	T1EE28	T1G597	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.635
T1EE28_HELRO	T1G7J9_HELRO	T1EE28	T1G7J9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.752
T1EE28_HELRO	T1G971_HELRO	T1EE28	T1G971	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the cyclin family.	0.807
T1EE28_HELRO	T1G9H1_HELRO	T1EE28	T1G9H1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.772
T1EE28_HELRO	cdc25	T1EE28	Q25122	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Hro-Cdc25.	0.635
T1EE44_HELRO	T1EE28_HELRO	T1EE44	T1EE28	Protein kinase domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.826