(11 nodes) Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, and Protein polyubiquitination network (Helobdella robusta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	T1EL91_HELRO	RING-type domain-containing protein. (70 aa)
	T1EL98_HELRO	RING-type domain-containing protein. (51 aa)
	T1EPB6_HELRO	Uncharacterized protein. (146 aa)
	T1FMZ5_HELRO	Ubiquitin-like domain-containing protein. (181 aa)
	T1FNV7_HELRO	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...] (340 aa)
	T1FPE0_HELRO	Ubiquitin-like domain-containing protein. (557 aa)
	T1FPE1_HELRO	Uncharacterized protein. (529 aa)
	T1FPN1_HELRO	RING-type domain-containing protein. (392 aa)
	T1FPU1_HELRO	RING-type domain-containing protein. (159 aa)
	T1FUH2_HELRO	RING-type domain-containing protein. (443 aa)
	T1G296_HELRO	Uncharacterized protein. (279 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EL98_HELRO	T1FPE0_HELRO	T1EL98	T1FPE0	RING-type domain-containing protein.	Ubiquitin-like domain-containing protein.	0.615
T1EL98_HELRO	T1FPE1_HELRO	T1EL98	T1FPE1	RING-type domain-containing protein.	Uncharacterized protein.	0.615
T1EL98_HELRO	T1G296_HELRO	T1EL98	T1G296	RING-type domain-containing protein.	Uncharacterized protein.	0.488
T1EPB6_HELRO	T1FMZ5_HELRO	T1EPB6	T1FMZ5	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.455
T1EPB6_HELRO	T1FNV7_HELRO	T1EPB6	T1FNV7	Uncharacterized protein.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.998
T1EPB6_HELRO	T1FPU1_HELRO	T1EPB6	T1FPU1	Uncharacterized protein.	RING-type domain-containing protein.	0.742
T1EPB6_HELRO	T1G296_HELRO	T1EPB6	T1G296	Uncharacterized protein.	Uncharacterized protein.	0.741
T1FMZ5_HELRO	T1EPB6_HELRO	T1FMZ5	T1EPB6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.455
T1FMZ5_HELRO	T1FNV7_HELRO	T1FMZ5	T1FNV7	Ubiquitin-like domain-containing protein.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.806
T1FMZ5_HELRO	T1FPE0_HELRO	T1FMZ5	T1FPE0	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.893
T1FMZ5_HELRO	T1FPE1_HELRO	T1FMZ5	T1FPE1	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.893
T1FMZ5_HELRO	T1FPU1_HELRO	T1FMZ5	T1FPU1	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.751
T1FMZ5_HELRO	T1G296_HELRO	T1FMZ5	T1G296	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.890
T1FNV7_HELRO	T1EPB6_HELRO	T1FNV7	T1EPB6	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	Uncharacterized protein.	0.998
T1FNV7_HELRO	T1FMZ5_HELRO	T1FNV7	T1FMZ5	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	Ubiquitin-like domain-containing protein.	0.806
T1FNV7_HELRO	T1FPE0_HELRO	T1FNV7	T1FPE0	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	Ubiquitin-like domain-containing protein.	0.655
T1FNV7_HELRO	T1FPE1_HELRO	T1FNV7	T1FPE1	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	Uncharacterized protein.	0.655
T1FNV7_HELRO	T1FPU1_HELRO	T1FNV7	T1FPU1	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	RING-type domain-containing protein.	0.906
T1FNV7_HELRO	T1G296_HELRO	T1FNV7	T1G296	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	Uncharacterized protein.	0.997
T1FPE0_HELRO	T1EL98_HELRO	T1FPE0	T1EL98	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.615