(18 nodes) HDACs deacetylate histones, and DNA binding, bending network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1ED10_HELRO	Uncharacterized protein. (1546 aa)
	T1EFT0_HELRO	Uncharacterized protein. (929 aa)
	T1EGH0_HELRO	Uncharacterized protein. (1877 aa)
	T1EJF5_HELRO	Uncharacterized protein. (162 aa)
	T1EKC3_HELRO	Uncharacterized protein. (1314 aa)
	T1EMC3_HELRO	WD_REPEATS_REGION domain-containing protein. (425 aa)
	T1EME7_HELRO	Uncharacterized protein. (231 aa)
	T1F465_HELRO	Uncharacterized protein. (372 aa)
	T1F672_HELRO	PHD-type domain-containing protein. (185 aa)
	T1FMY9_HELRO	MBD domain-containing protein. (239 aa)
	T1FP96_HELRO	Uncharacterized protein. (803 aa)
	T1FRB7_HELRO	HMG box domain-containing protein. (347 aa)
	T1FV13_HELRO	P66_CC domain-containing protein. (712 aa)
	T1FVB0_HELRO	P66_CC domain-containing protein. (773 aa)
	T1FWJ7_HELRO	Uncharacterized protein. (309 aa)
	T1FZN6_HELRO	Uncharacterized protein. (430 aa)
	T1G4W2_HELRO	HMG box domain-containing protein. (89 aa)
	T1G7V7_HELRO	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (799 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ED10_HELRO	T1EJF5_HELRO	T1ED10	T1EJF5	Uncharacterized protein.	Uncharacterized protein.	0.431
T1ED10_HELRO	T1EMC3_HELRO	T1ED10	T1EMC3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.943
T1ED10_HELRO	T1EME7_HELRO	T1ED10	T1EME7	Uncharacterized protein.	Uncharacterized protein.	0.431
T1ED10_HELRO	T1F465_HELRO	T1ED10	T1F465	Uncharacterized protein.	Uncharacterized protein.	0.779
T1ED10_HELRO	T1F672_HELRO	T1ED10	T1F672	Uncharacterized protein.	PHD-type domain-containing protein.	0.539
T1ED10_HELRO	T1FMY9_HELRO	T1ED10	T1FMY9	Uncharacterized protein.	MBD domain-containing protein.	0.907
T1ED10_HELRO	T1FP96_HELRO	T1ED10	T1FP96	Uncharacterized protein.	Uncharacterized protein.	0.926
T1ED10_HELRO	T1FRB7_HELRO	T1ED10	T1FRB7	Uncharacterized protein.	HMG box domain-containing protein.	0.432
T1ED10_HELRO	T1FV13_HELRO	T1ED10	T1FV13	Uncharacterized protein.	P66_CC domain-containing protein.	0.830
T1ED10_HELRO	T1FVB0_HELRO	T1ED10	T1FVB0	Uncharacterized protein.	P66_CC domain-containing protein.	0.830
T1ED10_HELRO	T1FWJ7_HELRO	T1ED10	T1FWJ7	Uncharacterized protein.	Uncharacterized protein.	0.725
T1ED10_HELRO	T1FZN6_HELRO	T1ED10	T1FZN6	Uncharacterized protein.	Uncharacterized protein.	0.779
T1ED10_HELRO	T1G4W2_HELRO	T1ED10	T1G4W2	Uncharacterized protein.	HMG box domain-containing protein.	0.431
T1ED10_HELRO	T1G7V7_HELRO	T1ED10	T1G7V7	Uncharacterized protein.	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.	0.791
T1EFT0_HELRO	T1EJF5_HELRO	T1EFT0	T1EJF5	Uncharacterized protein.	Uncharacterized protein.	0.431
T1EFT0_HELRO	T1EMC3_HELRO	T1EFT0	T1EMC3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.943
T1EFT0_HELRO	T1EME7_HELRO	T1EFT0	T1EME7	Uncharacterized protein.	Uncharacterized protein.	0.431
T1EFT0_HELRO	T1F465_HELRO	T1EFT0	T1F465	Uncharacterized protein.	Uncharacterized protein.	0.779
T1EFT0_HELRO	T1F672_HELRO	T1EFT0	T1F672	Uncharacterized protein.	PHD-type domain-containing protein.	0.539
T1EFT0_HELRO	T1FMY9_HELRO	T1EFT0	T1FMY9	Uncharacterized protein.	MBD domain-containing protein.	0.907