STRINGSTRING
T1ED11_HELRO T1ED11_HELRO T1EDI8_HELRO T1EDI8_HELRO T1EDL8_HELRO T1EDL8_HELRO T1EDX3_HELRO T1EDX3_HELRO T1EF10_HELRO T1EF10_HELRO T1EFC0_HELRO T1EFC0_HELRO T1EFT9_HELRO T1EFT9_HELRO T1EG57_HELRO T1EG57_HELRO T1EG91_HELRO T1EG91_HELRO T1EGF5_HELRO T1EGF5_HELRO T1EGK6_HELRO T1EGK6_HELRO T1EGT0_HELRO T1EGT0_HELRO T1ELF8_HELRO T1ELF8_HELRO T1ELF9_HELRO T1ELF9_HELRO T1ELG4_HELRO T1ELG4_HELRO T1ELL5_HELRO T1ELL5_HELRO T1EM49_HELRO T1EM49_HELRO T1EMF5_HELRO T1EMF5_HELRO T1EN92_HELRO T1EN92_HELRO T1EPE8_HELRO T1EPE8_HELRO T1EPG9_HELRO T1EPG9_HELRO T1EY95_HELRO T1EY95_HELRO T1EZB3_HELRO T1EZB3_HELRO T1F0F5_HELRO T1F0F5_HELRO T1FAC1_HELRO T1FAC1_HELRO T1FF83_HELRO T1FF83_HELRO T1FGC7_HELRO T1FGC7_HELRO T1FJN1_HELRO T1FJN1_HELRO T1FKA6_HELRO T1FKA6_HELRO T1FM58_HELRO T1FM58_HELRO T1FMH1_HELRO T1FMH1_HELRO T1FMP5_HELRO T1FMP5_HELRO T1FMT8_HELRO T1FMT8_HELRO T1FMY5_HELRO T1FMY5_HELRO T1FN54_HELRO T1FN54_HELRO T1FNC0_HELRO T1FNC0_HELRO T1FNJ5_HELRO T1FNJ5_HELRO T1FNW0_HELRO T1FNW0_HELRO T1FP80_HELRO T1FP80_HELRO T1FQ70_HELRO T1FQ70_HELRO T1FQF1_HELRO T1FQF1_HELRO T1FQW2_HELRO T1FQW2_HELRO T1FS42_HELRO T1FS42_HELRO T1FSL5_HELRO T1FSL5_HELRO T1FTG0_HELRO T1FTG0_HELRO T1FUG3_HELRO T1FUG3_HELRO T1FVS5_HELRO T1FVS5_HELRO T1FX17_HELRO T1FX17_HELRO T1FXA1_HELRO T1FXA1_HELRO T1FYW8_HELRO T1FYW8_HELRO T1FZC9_HELRO T1FZC9_HELRO T1FZE5_HELRO T1FZE5_HELRO T1G0K5_HELRO T1G0K5_HELRO T1G0L7_HELRO T1G0L7_HELRO T1G0T6_HELRO T1G0T6_HELRO T1G1F8_HELRO T1G1F8_HELRO T1G1H8_HELRO T1G1H8_HELRO T1G2H2_HELRO T1G2H2_HELRO T1G2N0_HELRO T1G2N0_HELRO T1G2N6_HELRO T1G2N6_HELRO T1G322_HELRO T1G322_HELRO T1G3G6_HELRO T1G3G6_HELRO T1G3M5_HELRO T1G3M5_HELRO T1G4K9_HELRO T1G4K9_HELRO T1G566_HELRO T1G566_HELRO T1G5E7_HELRO T1G5E7_HELRO T1G718_HELRO T1G718_HELRO T1G7C5_HELRO T1G7C5_HELRO T1G7D1_HELRO T1G7D1_HELRO T1G7P2_HELRO T1G7P2_HELRO T1G8H2_HELRO T1G8H2_HELRO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
T1ED11_HELRO3-hydroxy-3-methylglutaryl coenzyme A reductase. (932 aa)
T1EDI8_HELROVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (406 aa)
T1EDL8_HELROFA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (252 aa)
T1EDX3_HELROElongation of very long chain fatty acids protein. (197 aa)
T1EF10_HELROUncharacterized protein. (637 aa)
T1EFC0_HELROUncharacterized protein; Belongs to the FPP/GGPP synthase family. (316 aa)
T1EFT9_HELRONADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (664 aa)
T1EG57_HELRO5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (206 aa)
T1EG91_HELROUncharacterized protein; Belongs to the FPP/GGPP synthase family. (344 aa)
T1EGF5_HELRORab-GAP TBC domain-containing protein. (199 aa)
T1EGK6_HELROUncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
T1EGT0_HELROUbiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (415 aa)
T1ELF8_HELROMethyltransf_11 domain-containing protein. (282 aa)
T1ELF9_HELROMethyltransf_11 domain-containing protein. (311 aa)
T1ELG4_HELROBeta-lactamase domain-containing protein. (493 aa)
T1ELL5_HELROS5A_REDUCTASE domain-containing protein. (265 aa)
T1EM49_HELROUncharacterized protein; Belongs to the cytochrome P450 family. (443 aa)
T1EMF5_HELROUncharacterized protein; Belongs to the FPP/GGPP synthase family. (295 aa)
T1EN92_HELROUncharacterized protein; Belongs to the DOCK family. (2019 aa)
T1EPE8_HELROPolyketide_cyc domain-containing protein. (162 aa)
T1EPG9_HELROMethyltransf_11 domain-containing protein. (280 aa)
T1EY95_HELROUncharacterized protein. (190 aa)
T1EZB3_HELROUncharacterized protein; Belongs to the cytochrome P450 family. (128 aa)
T1F0F5_HELROGHMP_kinases_C domain-containing protein. (214 aa)
T1FAC1_HELRORUN domain-containing protein. (683 aa)
T1FF83_HELROUncharacterized protein. (522 aa)
T1FGC7_HELROUncharacterized protein. (172 aa)
T1FJN1_HELROF-box domain-containing protein. (382 aa)
T1FKA6_HELROMethyltranfer_dom domain-containing protein. (406 aa)
T1FM58_HELROUncharacterized protein. (518 aa)
T1FMH1_HELRODiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (406 aa)
T1FMP5_HELRO3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (510 aa)
T1FMT8_HELRO3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (349 aa)
T1FMY5_HELROUncharacterized protein; Belongs to the FPP/GGPP synthase family. (422 aa)
T1FN54_HELROABC1 domain-containing protein. (618 aa)
T1FNC0_HELROFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (374 aa)
T1FNJ5_HELROUbiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (306 aa)
T1FNW0_HELROUncharacterized protein. (162 aa)
T1FP80_HELROUncharacterized protein. (419 aa)
T1FQ70_HELROElongation of very long chain fatty acids protein. (347 aa)
T1FQF1_HELROUncharacterized protein. (597 aa)
T1FQW2_HELROABC1 domain-containing protein. (549 aa)
T1FS42_HELROElongation of very long chain fatty acids protein. (458 aa)
T1FSL5_HELROUncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
T1FTG0_HELROC-type lectin domain-containing protein. (750 aa)
T1FUG3_HELROUncharacterized protein. (279 aa)
T1FVS5_HELROR3H-assoc domain-containing protein. (643 aa)
T1FX17_HELROAlkyl transferase; Belongs to the UPP synthase family. (277 aa)
T1FXA1_HELROElongation of very long chain fatty acids protein. (282 aa)
T1FYW8_HELROVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (202 aa)
T1FZC9_HELROUncharacterized protein. (371 aa)
T1FZE5_HELROEpimerase domain-containing protein. (358 aa)
T1G0K5_HELROUncharacterized protein. (342 aa)
T1G0L7_HELRONudix hydrolase domain-containing protein. (228 aa)
T1G0T6_HELROMethyltransf_11 domain-containing protein. (215 aa)
T1G1F8_HELROGHMP_kinases_N domain-containing protein. (187 aa)
T1G1H8_HELRO4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (462 aa)
T1G2H2_HELROElongation of very long chain fatty acids protein. (265 aa)
T1G2N0_HELROABC1 domain-containing protein. (517 aa)
T1G2N6_HELROUncharacterized protein; Belongs to the cytochrome P450 family. (395 aa)
T1G322_HELROUncharacterized protein. (223 aa)
T1G3G6_HELROElongation of very long chain fatty acids protein. (266 aa)
T1G3M5_HELROUncharacterized protein. (430 aa)
T1G4K9_HELROTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (752 aa)
T1G566_HELROUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
T1G5E7_HELROUbiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (258 aa)
T1G718_HELROFAD-binding PCMH-type domain-containing protein. (515 aa)
T1G7C5_HELRO3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (370 aa)
T1G7D1_HELRO2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (283 aa)
T1G7P2_HELROUncharacterized protein. (281 aa)
T1G8H2_HELROFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (273 aa)
Your Current Organism:
Helobdella robusta
NCBI taxonomy Id: 6412
Other names: H. robusta
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