(12 nodes) Mitochondrial genome maintenance network (Helobdella robusta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1FXI1_HELRO	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	T1G5H7_HELRO	Uncharacterized protein. (108 aa)
	T1G035_HELRO	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (345 aa)
	T1EG29_HELRO	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1066 aa)
	T1EPQ7_HELRO	Uncharacterized protein. (199 aa)
	T1EKH7_HELRO	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance; Belongs to the MGME1 family. (220 aa)
	T1EFV9_HELRO	DNA ligase. (1013 aa)
	T1EPQ8_HELRO	ATP-dependent DNA helicase; Belongs to the helicase family. (179 aa)
	T1FA09_HELRO	DNApol_Exo domain-containing protein. (329 aa)
	T1FHA3_HELRO	Dna2 domain-containing protein. (345 aa)
	T1FRG7_HELRO	SF4 helicase domain-containing protein. (767 aa)
	T1FU49_HELRO	POLAc domain-containing protein. (416 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EFV9_HELRO	T1FHA3_HELRO	T1EFV9	T1FHA3	DNA ligase.	Dna2 domain-containing protein.	0.448
T1EG29_HELRO	T1EPQ7_HELRO	T1EG29	T1EPQ7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Uncharacterized protein.	0.508
T1EG29_HELRO	T1EPQ8_HELRO	T1EG29	T1EPQ8	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.508
T1EG29_HELRO	T1FHA3_HELRO	T1EG29	T1FHA3	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Dna2 domain-containing protein.	0.884
T1EG29_HELRO	T1G5H7_HELRO	T1EG29	T1G5H7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Uncharacterized protein.	0.823
T1EKH7_HELRO	T1FHA3_HELRO	T1EKH7	T1FHA3	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance; Belongs to the MGME1 family.	Dna2 domain-containing protein.	0.563
T1EKH7_HELRO	T1FRG7_HELRO	T1EKH7	T1FRG7	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance; Belongs to the MGME1 family.	SF4 helicase domain-containing protein.	0.562
T1EPQ7_HELRO	T1EG29_HELRO	T1EPQ7	T1EG29	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.508
T1EPQ7_HELRO	T1FHA3_HELRO	T1EPQ7	T1FHA3	Uncharacterized protein.	Dna2 domain-containing protein.	0.802
T1EPQ8_HELRO	T1EG29_HELRO	T1EPQ8	T1EG29	ATP-dependent DNA helicase; Belongs to the helicase family.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.508
T1EPQ8_HELRO	T1FHA3_HELRO	T1EPQ8	T1FHA3	ATP-dependent DNA helicase; Belongs to the helicase family.	Dna2 domain-containing protein.	0.802
T1FA09_HELRO	T1FHA3_HELRO	T1FA09	T1FHA3	DNApol_Exo domain-containing protein.	Dna2 domain-containing protein.	0.433
T1FA09_HELRO	T1FRG7_HELRO	T1FA09	T1FRG7	DNApol_Exo domain-containing protein.	SF4 helicase domain-containing protein.	0.558
T1FA09_HELRO	T1FU49_HELRO	T1FA09	T1FU49	DNApol_Exo domain-containing protein.	POLAc domain-containing protein.	0.958
T1FA09_HELRO	T1G5H7_HELRO	T1FA09	T1G5H7	DNApol_Exo domain-containing protein.	Uncharacterized protein.	0.609
T1FHA3_HELRO	T1EFV9_HELRO	T1FHA3	T1EFV9	Dna2 domain-containing protein.	DNA ligase.	0.448
T1FHA3_HELRO	T1EG29_HELRO	T1FHA3	T1EG29	Dna2 domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.884
T1FHA3_HELRO	T1EKH7_HELRO	T1FHA3	T1EKH7	Dna2 domain-containing protein.	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance; Belongs to the MGME1 family.	0.563
T1FHA3_HELRO	T1EPQ7_HELRO	T1FHA3	T1EPQ7	Dna2 domain-containing protein.	Uncharacterized protein.	0.802
T1FHA3_HELRO	T1EPQ8_HELRO	T1FHA3	T1EPQ8	Dna2 domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.802