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T1ED23_HELRO T1ED23_HELRO T1ED39_HELRO T1ED39_HELRO T1EDS8_HELRO T1EDS8_HELRO T1EE26_HELRO T1EE26_HELRO T1EE60_HELRO T1EE60_HELRO T1EEB6_HELRO T1EEB6_HELRO T1EEG2_HELRO T1EEG2_HELRO T1EEI4_HELRO T1EEI4_HELRO T1EET2_HELRO T1EET2_HELRO T1EF13_HELRO T1EF13_HELRO T1EF66_HELRO T1EF66_HELRO T1EF77_HELRO T1EF77_HELRO T1EFM7_HELRO T1EFM7_HELRO T1EHY6_HELRO T1EHY6_HELRO T1EJ96_HELRO T1EJ96_HELRO T1EJA4_HELRO T1EJA4_HELRO T1EJB8_HELRO T1EJB8_HELRO T1EJR8_HELRO T1EJR8_HELRO T1EL83_HELRO T1EL83_HELRO T1ELE1_HELRO T1ELE1_HELRO T1ELF5_HELRO T1ELF5_HELRO T1ELH7_HELRO T1ELH7_HELRO T1ELM5_HELRO T1ELM5_HELRO T1ELW0_HELRO T1ELW0_HELRO T1EM28_HELRO T1EM28_HELRO T1EMF1_HELRO T1EMF1_HELRO T1EMH6_HELRO T1EMH6_HELRO T1EQN2_HELRO T1EQN2_HELRO T1ERB6_HELRO T1ERB6_HELRO T1ERK7_HELRO T1ERK7_HELRO T1ERS8_HELRO T1ERS8_HELRO T1ERY1_HELRO T1ERY1_HELRO T1ERY2_HELRO T1ERY2_HELRO T1ES40_HELRO T1ES40_HELRO T1EVE5_HELRO T1EVE5_HELRO T1EY34_HELRO T1EY34_HELRO T1EYY4_HELRO T1EYY4_HELRO T1F0X0_HELRO T1F0X0_HELRO T1F2G2_HELRO T1F2G2_HELRO T1F2K9_HELRO T1F2K9_HELRO T1F4Z5_HELRO T1F4Z5_HELRO T1F8L8_HELRO T1F8L8_HELRO T1FBD9_HELRO T1FBD9_HELRO T1FF92_HELRO T1FF92_HELRO T1FFQ0_HELRO T1FFQ0_HELRO T1FGH8_HELRO T1FGH8_HELRO T1FIP2_HELRO T1FIP2_HELRO T1FKE0_HELRO T1FKE0_HELRO T1FKV4_HELRO T1FKV4_HELRO T1G9S1_HELRO T1G9S1_HELRO T1G9M8_HELRO T1G9M8_HELRO T1G9E5_HELRO T1G9E5_HELRO T1G993_HELRO T1G993_HELRO T1G896_HELRO T1G896_HELRO T1G822_HELRO T1G822_HELRO T1G7G7_HELRO T1G7G7_HELRO T1G7E5_HELRO T1G7E5_HELRO T1G782_HELRO T1G782_HELRO T1G751_HELRO T1G751_HELRO T1G676_HELRO T1G676_HELRO T1G5H0_HELRO T1G5H0_HELRO T1G4A2_HELRO T1G4A2_HELRO T1G380_HELRO T1G380_HELRO T1G321_HELRO T1G321_HELRO T1G2Z5_HELRO T1G2Z5_HELRO T1G1Q9_HELRO T1G1Q9_HELRO T1G1P2_HELRO T1G1P2_HELRO T1G1F6_HELRO T1G1F6_HELRO T1G1E2_HELRO T1G1E2_HELRO T1G0J9_HELRO T1G0J9_HELRO T1G0F2_HELRO T1G0F2_HELRO T1G0E9_HELRO T1G0E9_HELRO T1G0A8_HELRO T1G0A8_HELRO T1FZY9_HELRO T1FZY9_HELRO T1FZQ0_HELRO T1FZQ0_HELRO T1FZM6_HELRO T1FZM6_HELRO T1FZH3_HELRO T1FZH3_HELRO T1FZF8_HELRO T1FZF8_HELRO T1FZ95_HELRO T1FZ95_HELRO T1FZ94_HELRO T1FZ94_HELRO T1FYX2_HELRO T1FYX2_HELRO T1FYP5_HELRO T1FYP5_HELRO T1FY74_HELRO T1FY74_HELRO T1FXC4_HELRO T1FXC4_HELRO T1FX47_HELRO T1FX47_HELRO T1FWZ7_HELRO T1FWZ7_HELRO T1FWU8_HELRO T1FWU8_HELRO T1FWA2_HELRO T1FWA2_HELRO T1FVS8_HELRO T1FVS8_HELRO T1FVL0_HELRO T1FVL0_HELRO T1FUL4_HELRO T1FUL4_HELRO T1FU59_HELRO T1FU59_HELRO T1FTQ5_HELRO T1FTQ5_HELRO T1FTM5_HELRO T1FTM5_HELRO T1FTM4_HELRO T1FTM4_HELRO T1FSK6_HELRO T1FSK6_HELRO T1FSK3_HELRO T1FSK3_HELRO T1FRZ0_HELRO T1FRZ0_HELRO T1FRN5_HELRO T1FRN5_HELRO T1FQX7_HELRO T1FQX7_HELRO T1FQV4_HELRO T1FQV4_HELRO T1FQH1_HELRO T1FQH1_HELRO T1FPG8_HELRO T1FPG8_HELRO T1FPG4_HELRO T1FPG4_HELRO T1FPD6_HELRO T1FPD6_HELRO T1FNU6_HELRO T1FNU6_HELRO T1FNA7_HELRO T1FNA7_HELRO T1FM97_HELRO T1FM97_HELRO T1FM37_HELRO T1FM37_HELRO T1FM25_HELRO T1FM25_HELRO
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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T1ED23_HELROAA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1067 aa)
T1ED39_HELROProtein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (435 aa)
T1EDS8_HELROUncharacterized protein. (848 aa)
T1EE26_HELROUncharacterized protein. (738 aa)
T1EE60_HELROAdenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] (565 aa)
T1EEB6_HELROtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (319 aa)
T1EEG2_HELRODTW domain-containing protein. (317 aa)
T1EEI4_HELROGIDA_assoc domain-containing protein. (694 aa)
T1EET2_HELROUncharacterized protein. (675 aa)
T1EF13_HELRORNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (983 aa)
T1EF66_HELROtRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (480 aa)
T1EF77_HELROQueuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (454 aa)
T1EFM7_HELROAA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (840 aa)
T1EHY6_HELROUPF0020 domain-containing protein. (351 aa)
T1EJ96_HELROUncharacterized protein. (207 aa)
T1EJA4_HELROUncharacterized protein. (113 aa)
T1EJB8_HELROUncharacterized protein. (142 aa)
T1EJR8_HELRORibonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (110 aa)
T1EL83_HELRODPH-type MB domain-containing protein. (61 aa)
T1ELE1_HELROCMP/dCMP-type deaminase domain-containing protein. (317 aa)
T1ELF5_HELROPseudoU_synth_1 domain-containing protein. (439 aa)
T1ELH7_HELROArchease domain-containing protein. (105 aa)
T1ELM5_HELROtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (289 aa)
T1ELW0_HELROProtein kinase domain-containing protein. (220 aa)
T1EM28_HELROPutative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (293 aa)
T1EMF1_HELROUncharacterized protein. (562 aa)
T1EMH6_HELROtRNA (guanine(26)-N(2))-dimethyltransferase. (509 aa)
T1EQN2_HELROUncharacterized protein. (1330 aa)
T1ERB6_HELROUncharacterized protein. (225 aa)
T1ERK7_HELROA to I editase domain-containing protein. (394 aa)
T1ERS8_HELROUncharacterized protein. (183 aa)
T1ERY1_HELROUncharacterized protein. (717 aa)
T1ERY2_HELROUncharacterized protein. (330 aa)
T1ES40_HELROUncharacterized protein. (588 aa)
T1EVE5_HELROUncharacterized protein. (411 aa)
T1EY34_HELROUncharacterized protein. (124 aa)
T1EYY4_HELROUncharacterized protein. (989 aa)
T1F0X0_HELRORRM domain-containing protein. (838 aa)
T1F2G2_HELROtRNA pseudouridine synthase. (249 aa)
T1F2K9_HELROUncharacterized protein. (425 aa)
T1F4Z5_HELROUncharacterized protein. (636 aa)
T1F8L8_HELROUncharacterized protein; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (453 aa)
T1FBD9_HELROUncharacterized protein; Belongs to the CGI121/TPRKB family. (114 aa)
T1FF92_HELROUncharacterized protein. (554 aa)
T1FFQ0_HELROUncharacterized protein; Belongs to the IPP transferase family. (516 aa)
T1FGH8_HELROtRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (387 aa)
T1FIP2_HELROYrdC-like domain-containing protein. (203 aa)
T1FKE0_HELROtRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (284 aa)
T1FKV4_HELRORadical_SAM_C domain-containing protein. (149 aa)
T1G9S1_HELROtRNA pseudouridine synthase. (285 aa)
T1G9M8_HELROUbiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxid [...] (100 aa)
T1G9E5_HELROCytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (331 aa)
T1G993_HELROUncharacterized protein. (494 aa)
T1G896_HELROtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (255 aa)
T1G822_HELROProbable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (415 aa)
T1G7G7_HELROUncharacterized protein. (361 aa)
T1G7E5_HELROUncharacterized protein. (174 aa)
T1G782_HELROUncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (345 aa)
T1G751_HELROUncharacterized protein. (313 aa)
T1G676_HELROANK_REP_REGION domain-containing protein. (220 aa)
T1G5H0_HELROTHUMP domain-containing protein. (279 aa)
T1G4A2_HELRON-acetyltransferase domain-containing protein. (438 aa)
T1G380_HELROTsaA-like domain-containing protein. (181 aa)
T1G321_HELROCHHC U11-48K-type domain-containing protein. (430 aa)
T1G2Z5_HELRORibonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (195 aa)
T1G1Q9_HELROC3H1-type domain-containing protein. (412 aa)
T1G1P2_HELRODTW domain-containing protein. (238 aa)
T1G1F6_HELROTYW3 domain-containing protein. (195 aa)
T1G1E2_HELROQueuosine salvage protein; Involved in salvaging queuosine. (345 aa)
T1G0J9_HELROMethyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (263 aa)
T1G0F2_HELROProtein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (419 aa)
T1G0E9_HELROUncharacterized protein. (318 aa)
T1G0A8_HELROTruB_N domain-containing protein. (212 aa)
T1FZY9_HELROUncharacterized protein. (165 aa)
T1FZQ0_HELROFe2OG dioxygenase domain-containing protein. (558 aa)
T1FZM6_HELROFDX-ACB domain-containing protein. (414 aa)
T1FZH3_HELROUncharacterized protein. (345 aa)
T1FZF8_HELROSAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (673 aa)
T1FZ95_HELROSpoU_methylase domain-containing protein. (176 aa)
T1FZ94_HELROSAM-dependent MTase TRM10-type domain-containing protein. (234 aa)
T1FYX2_HELROSAM_MT_TRM5_TYW2 domain-containing protein. (319 aa)
T1FYP5_HELROUncharacterized protein. (284 aa)
T1FY74_HELRODUF2428 domain-containing protein. (307 aa)
T1FXC4_HELROTRUD domain-containing protein. (524 aa)
T1FX47_HELROTHUMP domain-containing protein. (275 aa)
T1FWZ7_HELROUncharacterized protein. (201 aa)
T1FWU8_HELROSAM-dependent MTase TRM10-type domain-containing protein. (295 aa)
T1FWA2_HELROCMP/dCMP-type deaminase domain-containing protein. (175 aa)
T1FVS8_HELROUncharacterized protein. (378 aa)
T1FVL0_HELROJmjC domain-containing protein. (367 aa)
T1FUL4_HELROPRORP domain-containing protein. (569 aa)
T1FU59_HELRODUF2428 domain-containing protein. (1641 aa)
T1FTQ5_HELROtRNA_int_end_N2 domain-containing protein. (731 aa)
T1FTM5_HELROUncharacterized protein. (356 aa)
T1FTM4_HELROUncharacterized protein. (169 aa)
T1FSK6_HELROTHUMP domain-containing protein. (533 aa)
T1FSK3_HELROUncharacterized protein. (479 aa)
T1FRZ0_HELROAlba domain-containing protein. (164 aa)
T1FRN5_HELROUncharacterized protein. (243 aa)
T1FQX7_HELROUncharacterized protein. (908 aa)
T1FQV4_HELROFlavodoxin-like domain-containing protein. (743 aa)
T1FQH1_HELROUncharacterized protein. (1439 aa)
T1FPG8_HELROMethyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (357 aa)
T1FPG4_HELROUncharacterized protein. (274 aa)
T1FPD6_HELROUncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (223 aa)
T1FNU6_HELROHflx-type G domain-containing protein. (499 aa)
T1FNA7_HELROProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (336 aa)
T1FM97_HELROQueuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (398 aa)
T1FM37_HELRODNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (107 aa)
T1FM25_HELRORNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs; Belongs to the RtcB family. (505 aa)
Your Current Organism:
Helobdella robusta
NCBI taxonomy Id: 6412
Other names: H. robusta
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