(89 nodes) Protein processing network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1FTB9_HELRO	Metalloendopeptidase. (1101 aa)
	T1FTJ8_HELRO	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (263 aa)
	T1FUV4_HELRO	Uncharacterized protein. (597 aa)
	T1FV66_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (593 aa)
	T1FVA2_HELRO	M16C_associated domain-containing protein. (1067 aa)
	T1FVI3_HELRO	Uncharacterized protein. (1187 aa)
	T1FVU8_HELRO	Peptidase_S8 domain-containing protein. (1109 aa)
	T1FW54_HELRO	Peptidase M12B domain-containing protein. (560 aa)
	T1FWG2_HELRO	Peptidase_M14 domain-containing protein. (132 aa)
	T1FY45_HELRO	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (448 aa)
	T1FY48_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (482 aa)
	T1FZR0_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (656 aa)
	T1G0E5_HELRO	Uncharacterized protein. (207 aa)
	T1G106_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (539 aa)
	T1G1H4_HELRO	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (375 aa)
	T1G1I0_HELRO	Uncharacterized protein. (186 aa)
	T1G1J2_HELRO	SprT-like domain-containing protein. (236 aa)
	T1G1M9_HELRO	P/Homo B domain-containing protein. (391 aa)
	T1G245_HELRO	Uncharacterized protein. (373 aa)
	T1G263_HELRO	AAA domain-containing protein. (521 aa)
	T1G2U2_HELRO	Signal peptidase complex subunit 3. (180 aa)
	T1G3C2_HELRO	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (97 aa)
	T1G3V4_HELRO	Uncharacterized protein. (197 aa)
	T1G4I9_HELRO	Peptidase_S8 domain-containing protein. (346 aa)
	T1G4R0_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (661 aa)
	T1G4Y7_HELRO	P/Homo B domain-containing protein. (446 aa)
	T1G5N0_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (570 aa)
	T1G6K9_HELRO	Uncharacterized protein; Belongs to the peptidase C14A family. (209 aa)
	T1G6N3_HELRO	Metalloendopeptidase. (821 aa)
	T1G6P3_HELRO	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (386 aa)
	T1G738_HELRO	Uncharacterized protein; Belongs to the peptidase C1 family. (531 aa)
	T1G7F6_HELRO	Uncharacterized protein. (99 aa)
	T1G7M3_HELRO	Peptidase_M13 domain-containing protein. (183 aa)
	T1G8R2_HELRO	Uncharacterized protein. (79 aa)
	T1G8R3_HELRO	Peptidase_S8 domain-containing protein. (164 aa)
	T1G8S6_HELRO	Peptidase_S8 domain-containing protein. (185 aa)
	T1G8W9_HELRO	Peptidase_S24 domain-containing protein. (201 aa)
	T1G979_HELRO	Peptidase_M48 domain-containing protein. (447 aa)
	T1G9B6_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (609 aa)
	T1G9Q4_HELRO	Uncharacterized protein. (269 aa)
	T1EF32_HELRO	Uncharacterized protein. (773 aa)
	T1EFL0_HELRO	Uncharacterized protein. (486 aa)
	T1EFS9_HELRO	Uncharacterized protein. (456 aa)
	T1EFX5_HELRO	PHB domain-containing protein. (397 aa)
	T1EFZ6_HELRO	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (586 aa)
	T1EG31_HELRO	Rhomboid domain-containing protein. (342 aa)
	T1EGI3_HELRO	Uncharacterized protein. (1126 aa)
	T1EHJ5_HELRO	Uncharacterized protein. (69 aa)
	T1EDT0_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (654 aa)
	T1EEE2_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (730 aa)
	T1EHY7_HELRO	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (237 aa)
	T1EDJ0_HELRO	TPR_REGION domain-containing protein. (1054 aa)
	T1EJZ7_HELRO	CUB domain-containing protein. (98 aa)
	T1EI55_HELRO	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (98 aa)
	T1ELE5_HELRO	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (1075 aa)
	T1ELI3_HELRO	Uncharacterized protein. (170 aa)
	T1EPI1_HELRO	Uncharacterized protein. (594 aa)
	T1ERH9_HELRO	Peptidase_M3 domain-containing protein. (682 aa)
	T1F2W7_HELRO	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (664 aa)
	T1F702_HELRO	Methyltransf_21 domain-containing protein. (297 aa)
	T1F705_HELRO	Uncharacterized protein. (139 aa)
	T1F717_HELRO	Methyltransf_21 domain-containing protein. (264 aa)
	T1F8S6_HELRO	Uncharacterized protein. (607 aa)
	T1F8V8_HELRO	Methyltransf_21 domain-containing protein. (234 aa)
	T1FAJ5_HELRO	Methyltransf_21 domain-containing protein. (322 aa)
	T1FBB9_HELRO	Uncharacterized protein; Belongs to the peptidase C14A family. (330 aa)
	T1FC41_HELRO	Uncharacterized protein. (664 aa)
	T1FC42_HELRO	Uncharacterized protein. (603 aa)
	T1FC43_HELRO	Uncharacterized protein. (678 aa)
	T1FDZ0_HELRO	Rhomboid domain-containing protein. (213 aa)
	T1FEF7_HELRO	ADAM_CR_2 domain-containing protein. (335 aa)
	T1FH53_HELRO	Uncharacterized protein. (493 aa)
	T1FH54_HELRO	Peptidase_M13_N domain-containing protein. (287 aa)
	T1FHI6_HELRO	Peptidase_M13_N domain-containing protein. (143 aa)
	T1FKE5_HELRO	Methyltransf_21 domain-containing protein. (281 aa)
	T1FKE6_HELRO	Methyltransf_21 domain-containing protein. (284 aa)
	T1FKG6_HELRO	P/Homo B domain-containing protein. (465 aa)
	T1FKW6_HELRO	Peptidase_M13 domain-containing protein. (320 aa)
	T1FMN3_HELRO	Uncharacterized protein. (454 aa)
	T1FNM1_HELRO	AMP_N domain-containing protein. (488 aa)
	T1FNN5_HELRO	Uncharacterized protein; Belongs to the peptidase M16 family. (548 aa)
	T1FPA3_HELRO	Uncharacterized protein. (350 aa)
	T1FPD8_HELRO	Uncharacterized protein. (663 aa)
	T1FPP6_HELRO	F5/8 type C domain-containing protein. (416 aa)
	T1FPY7_HELRO	Methyltransf_21 domain-containing protein. (313 aa)
	T1FPZ5_HELRO	Uncharacterized protein. (799 aa)
	T1FQ60_HELRO	Uncharacterized protein. (1194 aa)
	T1FSB4_HELRO	Ncstrn_small domain-containing protein. (773 aa)
	T1FSJ2_HELRO	Uncharacterized protein. (329 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EDJ0_HELRO	T1FVA2_HELRO	T1EDJ0	T1FVA2	TPR_REGION domain-containing protein.	M16C_associated domain-containing protein.	0.501
T1EFL0_HELRO	T1G9B6_HELRO	T1EFL0	T1G9B6	Uncharacterized protein.	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.471
T1EFX5_HELRO	T1EG31_HELRO	T1EFX5	T1EG31	PHB domain-containing protein.	Rhomboid domain-containing protein.	0.706
T1EFX5_HELRO	T1FDZ0_HELRO	T1EFX5	T1FDZ0	PHB domain-containing protein.	Rhomboid domain-containing protein.	0.706
T1EFX5_HELRO	T1FNN5_HELRO	T1EFX5	T1FNN5	PHB domain-containing protein.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.442
T1EFX5_HELRO	T1FY48_HELRO	T1EFX5	T1FY48	PHB domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.821
T1EFX5_HELRO	T1FZR0_HELRO	T1EFX5	T1FZR0	PHB domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.700
T1EFX5_HELRO	T1G263_HELRO	T1EFX5	T1G263	PHB domain-containing protein.	AAA domain-containing protein.	0.684
T1EFZ6_HELRO	T1FSB4_HELRO	T1EFZ6	T1FSB4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ncstrn_small domain-containing protein.	0.993
T1EFZ6_HELRO	T1G6P3_HELRO	T1EFZ6	T1G6P3	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.903
T1EFZ6_HELRO	T1G7F6_HELRO	T1EFZ6	T1G7F6	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.989
T1EFZ6_HELRO	T1G9Q4_HELRO	T1EFZ6	T1G9Q4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.990
T1EG31_HELRO	T1EFX5_HELRO	T1EG31	T1EFX5	Rhomboid domain-containing protein.	PHB domain-containing protein.	0.706
T1EG31_HELRO	T1FNN5_HELRO	T1EG31	T1FNN5	Rhomboid domain-containing protein.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.418
T1EG31_HELRO	T1FY48_HELRO	T1EG31	T1FY48	Rhomboid domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.731
T1EG31_HELRO	T1FZR0_HELRO	T1EG31	T1FZR0	Rhomboid domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.554
T1EG31_HELRO	T1G263_HELRO	T1EG31	T1G263	Rhomboid domain-containing protein.	AAA domain-containing protein.	0.555
T1EG31_HELRO	T1G979_HELRO	T1EG31	T1G979	Rhomboid domain-containing protein.	Peptidase_M48 domain-containing protein.	0.419
T1EHJ5_HELRO	T1FPA3_HELRO	T1EHJ5	T1FPA3	Uncharacterized protein.	Uncharacterized protein.	0.568
T1EHJ5_HELRO	T1G1I0_HELRO	T1EHJ5	T1G1I0	Uncharacterized protein.	Uncharacterized protein.	0.997