(15 nodes) Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1FMU4_HELRO	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (475 aa)
	T1FMR2_HELRO	Uncharacterized protein. (315 aa)
	T1FIY0_HELRO	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (175 aa)
	T1FB30_HELRO	Uncharacterized protein. (567 aa)
	T1F6W6_HELRO	Uncharacterized protein. (484 aa)
	T1EH20_HELRO	Uncharacterized protein. (161 aa)
	T1EG80_HELRO	Lactamase_B domain-containing protein. (313 aa)
	T1FPC2_HELRO	Cysteine dioxygenase. (215 aa)
	T1FQA1_HELRO	Uncharacterized protein. (1248 aa)
	T1FV96_HELRO	Uncharacterized protein; Belongs to the pirin family. (279 aa)
	T1FYK1_HELRO	Lipoxygenase domain-containing protein. (891 aa)
	T1FYM2_HELRO	Uncharacterized protein. (665 aa)
	T1G801_HELRO	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (175 aa)
	T1FNN4_HELRO	4-hydroxyphenylpyruvate dioxygenase. (382 aa)
	T1FN21_HELRO	Uncharacterized protein. (458 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EG80_HELRO	T1FNN4_HELRO	T1EG80	T1FNN4	Lactamase_B domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.718
T1EH20_HELRO	T1FPC2_HELRO	T1EH20	T1FPC2	Uncharacterized protein.	Cysteine dioxygenase.	0.644
T1FIY0_HELRO	T1G801_HELRO	T1FIY0	T1G801	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.901
T1FMR2_HELRO	T1FMU4_HELRO	T1FMR2	T1FMU4	Uncharacterized protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.649
T1FMR2_HELRO	T1FN21_HELRO	T1FMR2	T1FN21	Uncharacterized protein.	Uncharacterized protein.	0.433
T1FMU4_HELRO	T1FMR2_HELRO	T1FMU4	T1FMR2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Uncharacterized protein.	0.649
T1FMU4_HELRO	T1FN21_HELRO	T1FMU4	T1FN21	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Uncharacterized protein.	0.482
T1FMU4_HELRO	T1FNN4_HELRO	T1FMU4	T1FNN4	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	4-hydroxyphenylpyruvate dioxygenase.	0.508
T1FN21_HELRO	T1FMR2_HELRO	T1FN21	T1FMR2	Uncharacterized protein.	Uncharacterized protein.	0.433
T1FN21_HELRO	T1FMU4_HELRO	T1FN21	T1FMU4	Uncharacterized protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.482
T1FN21_HELRO	T1FNN4_HELRO	T1FN21	T1FNN4	Uncharacterized protein.	4-hydroxyphenylpyruvate dioxygenase.	0.999
T1FNN4_HELRO	T1EG80_HELRO	T1FNN4	T1EG80	4-hydroxyphenylpyruvate dioxygenase.	Lactamase_B domain-containing protein.	0.718
T1FNN4_HELRO	T1FMU4_HELRO	T1FNN4	T1FMU4	4-hydroxyphenylpyruvate dioxygenase.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.508
T1FNN4_HELRO	T1FN21_HELRO	T1FNN4	T1FN21	4-hydroxyphenylpyruvate dioxygenase.	Uncharacterized protein.	0.999
T1FPC2_HELRO	T1EH20_HELRO	T1FPC2	T1EH20	Cysteine dioxygenase.	Uncharacterized protein.	0.644
T1FYK1_HELRO	T1FYM2_HELRO	T1FYK1	T1FYM2	Lipoxygenase domain-containing protein.	Uncharacterized protein.	0.917
T1FYM2_HELRO	T1FYK1_HELRO	T1FYM2	T1FYK1	Uncharacterized protein.	Lipoxygenase domain-containing protein.	0.917
T1G801_HELRO	T1FIY0_HELRO	T1G801	T1FIY0	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.901