(59 nodes) Purine nucleoside bisphosphate metabolic process network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	T1G1X4_HELRO	AMP-binding domain-containing protein. (708 aa)
	T1FYF4_HELRO	Aminotran_1_2 domain-containing protein. (332 aa)
	T1FYT7_HELRO	Nudix hydrolase domain-containing protein. (242 aa)
	T1G8V2_HELRO	PlsC domain-containing protein. (529 aa)
	T1G9N3_HELRO	Uncharacterized protein. (732 aa)
	T1G371_HELRO	Uncharacterized protein. (282 aa)
	T1EQT9_HELRO	Uncharacterized protein. (110 aa)
	T1ERL7_HELRO	Uncharacterized protein. (379 aa)
	T1ESM6_HELRO	Nudix hydrolase domain-containing protein. (369 aa)
	T1EUC2_HELRO	VOC domain-containing protein. (179 aa)
	T1EV62_HELRO	2-oxoacid_dh domain-containing protein. (279 aa)
	T1EY95_HELRO	Uncharacterized protein. (190 aa)
	T1F0F5_HELRO	GHMP_kinases_C domain-containing protein. (214 aa)
	T1F997_HELRO	MaoC-like domain-containing protein. (163 aa)
	T1FB48_HELRO	Uncharacterized protein. (310 aa)
	T1FM29_HELRO	Uncharacterized protein. (105 aa)
	T1G5P2_HELRO	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (479 aa)
	T1G4V7_HELRO	CTP_transf_like domain-containing protein. (516 aa)
	T1G421_HELRO	Lipoyl-binding domain-containing protein. (395 aa)
	T1G3G6_HELRO	Elongation of very long chain fatty acids protein. (266 aa)
	T1FMH1_HELRO	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (406 aa)
	T1FMJ8_HELRO	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (463 aa)
	T1FMP5_HELRO	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (510 aa)
	T1FNI4_HELRO	Uncharacterized protein. (108 aa)
	T1FP71_HELRO	Uncharacterized protein. (371 aa)
	T1FPJ5_HELRO	Uncharacterized protein. (130 aa)
	T1FQ70_HELRO	Elongation of very long chain fatty acids protein. (347 aa)
	T1FQS0_HELRO	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)
	T1FQS6_HELRO	Uncharacterized protein. (230 aa)
	T1EGG3_HELRO	Uncharacterized protein. (605 aa)
	T1EFE6_HELRO	Uncharacterized protein. (622 aa)
	T1FXA1_HELRO	Elongation of very long chain fatty acids protein. (282 aa)
	T1FW09_HELRO	Uncharacterized protein. (486 aa)
	T1FS42_HELRO	Elongation of very long chain fatty acids protein. (458 aa)
	T1FRZ9_HELRO	AMP-binding domain-containing protein. (716 aa)
	T1FRT6_HELRO	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (421 aa)
	T1ED11_HELRO	3-hydroxy-3-methylglutaryl coenzyme A reductase. (932 aa)
	T1ED95_HELRO	Uncharacterized protein. (449 aa)
	T1EDC7_HELRO	Acetyl-coenzyme A synthetase. (678 aa)
	T1EDF7_HELRO	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (448 aa)
	T1EDX3_HELRO	Elongation of very long chain fatty acids protein. (197 aa)
	T1EER4_HELRO	DUF89 domain-containing protein. (834 aa)
	T1EF02_HELRO	AMP-binding domain-containing protein. (715 aa)
	T1EF58_HELRO	Uncharacterized protein. (953 aa)
	T1EFC1_HELRO	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (554 aa)
	T1FXP6_HELRO	Uncharacterized protein. (601 aa)
	T1G1F8_HELRO	GHMP_kinases_N domain-containing protein. (187 aa)
	T1G118_HELRO	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (542 aa)
	T1G0E1_HELRO	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (521 aa)
	T1G036_HELRO	Uncharacterized protein. (2126 aa)
	T1G034_HELRO	Flavoprotein domain-containing protein. (211 aa)
	T1G003_HELRO	Biotin carboxylation domain-containing protein. (154 aa)
	T1FZM3_HELRO	Lipoyl-binding domain-containing protein. (167 aa)
	T1EMJ6_HELRO	HD domain-containing protein. (186 aa)
	T1ELL0_HELRO	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (333 aa)
	T1G5R3_HELRO	Uncharacterized protein. (326 aa)
	T1ELJ3_HELRO	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1081 aa)
	T1EJ84_HELRO	Uncharacterized protein. (252 aa)
	T1FXK0_HELRO	Nudix hydrolase domain-containing protein. (178 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ED11_HELRO	T1EDC7_HELRO	T1ED11	T1EDC7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Acetyl-coenzyme A synthetase.	0.459
T1ED11_HELRO	T1EF02_HELRO	T1ED11	T1EF02	3-hydroxy-3-methylglutaryl coenzyme A reductase.	AMP-binding domain-containing protein.	0.410
T1ED11_HELRO	T1ELJ3_HELRO	T1ED11	T1ELJ3	3-hydroxy-3-methylglutaryl coenzyme A reductase.	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	0.405
T1ED11_HELRO	T1EY95_HELRO	T1ED11	T1EY95	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.606
T1ED11_HELRO	T1F0F5_HELRO	T1ED11	T1F0F5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	GHMP_kinases_C domain-containing protein.	0.907
T1ED11_HELRO	T1FMH1_HELRO	T1ED11	T1FMH1	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.779
T1ED11_HELRO	T1FMP5_HELRO	T1ED11	T1FMP5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
T1ED11_HELRO	T1FRZ9_HELRO	T1ED11	T1FRZ9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	AMP-binding domain-containing protein.	0.410
T1ED11_HELRO	T1G003_HELRO	T1ED11	T1G003	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Biotin carboxylation domain-containing protein.	0.445
T1ED11_HELRO	T1G036_HELRO	T1ED11	T1G036	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.445
T1ED11_HELRO	T1G1F8_HELRO	T1ED11	T1G1F8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	GHMP_kinases_N domain-containing protein.	0.990
T1ED11_HELRO	T1G1X4_HELRO	T1ED11	T1G1X4	3-hydroxy-3-methylglutaryl coenzyme A reductase.	AMP-binding domain-containing protein.	0.410
T1ED11_HELRO	T1G4V7_HELRO	T1ED11	T1G4V7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	CTP_transf_like domain-containing protein.	0.636
T1ED95_HELRO	T1FB48_HELRO	T1ED95	T1FB48	Uncharacterized protein.	Uncharacterized protein.	0.533
T1ED95_HELRO	T1FP71_HELRO	T1ED95	T1FP71	Uncharacterized protein.	Uncharacterized protein.	0.499
T1ED95_HELRO	T1FW09_HELRO	T1ED95	T1FW09	Uncharacterized protein.	Uncharacterized protein.	0.560
T1EDC7_HELRO	T1ED11_HELRO	T1EDC7	T1ED11	Acetyl-coenzyme A synthetase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.459
T1EDC7_HELRO	T1EDF7_HELRO	T1EDC7	T1EDF7	Acetyl-coenzyme A synthetase.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.874
T1EDC7_HELRO	T1EFC1_HELRO	T1EDC7	T1EFC1	Acetyl-coenzyme A synthetase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.944
T1EDC7_HELRO	T1EGG3_HELRO	T1EDC7	T1EGG3	Acetyl-coenzyme A synthetase.	Uncharacterized protein.	0.540