(22 nodes) Phosphatidylinositol-mediated signaling network (Helobdella robusta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	T1FY69_HELRO	Phosphoinositide phospholipase C. (1030 aa)
	T1EFT4_HELRO	G_PROTEIN_RECEP_F1_2 domain-containing protein. (333 aa)
	T1EFP5_HELRO	Phosphatidylinositol 3-kinase catalytic subunit type 3. (915 aa)
	T1EEX3_HELRO	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
	T1EDJ0_HELRO	TPR_REGION domain-containing protein. (1054 aa)
	T1G2I0_HELRO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (885 aa)
	T1G143_HELRO	G_PROTEIN_RECEP_F1_2 domain-containing protein. (372 aa)
	T1G0G0_HELRO	Phosphoinositide phospholipase C. (390 aa)
	T1FX15_HELRO	Phosphoinositide phospholipase C. (468 aa)
	T1FWM7_HELRO	Uncharacterized protein. (1250 aa)
	T1EFY2_HELRO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (321 aa)
	T1ERP3_HELRO	Uncharacterized protein. (1646 aa)
	T1FQ83_HELRO	Ras-GEF domain-containing protein. (426 aa)
	T1EGJ8_HELRO	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (441 aa)
	T1FQR0_HELRO	Phosphoinositide phospholipase C. (1506 aa)
	T1EGP2_HELRO	Uncharacterized protein. (284 aa)
	T1EK23_HELRO	PLCXc domain-containing protein. (70 aa)
	T1EKN1_HELRO	Phosphatase tensin-type domain-containing protein. (171 aa)
	T1ELN4_HELRO	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1060 aa)
	T1G9A0_HELRO	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1049 aa)
	T1G934_HELRO	Phosphoinositide phospholipase C. (450 aa)
	T1G8B5_HELRO	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1112 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EEX3_HELRO	T1EFP5_HELRO	T1EEX3	T1EFP5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.650
T1EEX3_HELRO	T1EGJ8_HELRO	T1EEX3	T1EGJ8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.655
T1EEX3_HELRO	T1EGP2_HELRO	T1EEX3	T1EGP2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Uncharacterized protein.	0.901
T1EEX3_HELRO	T1EKN1_HELRO	T1EEX3	T1EKN1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphatase tensin-type domain-containing protein.	0.901
T1EEX3_HELRO	T1ELN4_HELRO	T1EEX3	T1ELN4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.903
T1EEX3_HELRO	T1FQR0_HELRO	T1EEX3	T1FQR0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.905
T1EEX3_HELRO	T1FWM7_HELRO	T1EEX3	T1FWM7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Uncharacterized protein.	0.655
T1EEX3_HELRO	T1FX15_HELRO	T1EEX3	T1FX15	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.769
T1EEX3_HELRO	T1G0G0_HELRO	T1EEX3	T1G0G0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.772
T1EEX3_HELRO	T1G2I0_HELRO	T1EEX3	T1G2I0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.650
T1EEX3_HELRO	T1G8B5_HELRO	T1EEX3	T1G8B5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.902
T1EEX3_HELRO	T1G934_HELRO	T1EEX3	T1G934	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.774
T1EEX3_HELRO	T1G9A0_HELRO	T1EEX3	T1G9A0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.903
T1EFP5_HELRO	T1EEX3_HELRO	T1EFP5	T1EEX3	Phosphatidylinositol 3-kinase catalytic subunit type 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.650
T1EFP5_HELRO	T1EFY2_HELRO	T1EFP5	T1EFY2	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.855
T1EFP5_HELRO	T1EGJ8_HELRO	T1EFP5	T1EGJ8	Phosphatidylinositol 3-kinase catalytic subunit type 3.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.917
T1EFP5_HELRO	T1EGP2_HELRO	T1EFP5	T1EGP2	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein.	0.929
T1EFP5_HELRO	T1EKN1_HELRO	T1EFP5	T1EKN1	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatase tensin-type domain-containing protein.	0.929
T1EFP5_HELRO	T1ELN4_HELRO	T1EFP5	T1ELN4	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.816
T1EFP5_HELRO	T1FQR0_HELRO	T1EFP5	T1FQR0	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphoinositide phospholipase C.	0.650