(95 nodes) Meiotic cell cycle network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1ECZ1_HELRO	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (453 aa)
	T1EDL1_HELRO	TACC_C domain-containing protein. (161 aa)
	T1EE44_HELRO	Protein kinase domain-containing protein. (539 aa)
	T1EEQ9_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (404 aa)
	T1EEY5_HELRO	Uncharacterized protein. (1226 aa)
	T1EF80_HELRO	PLD phosphodiesterase domain-containing protein. (222 aa)
	T1EFD3_HELRO	FHA domain-containing protein. (769 aa)
	T1EG41_HELRO	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
	T1EG71_HELRO	Deacetylase sirtuin-type domain-containing protein. (312 aa)
	T1EGK8_HELRO	Uncharacterized protein. (738 aa)
	T1EI28_HELRO	NYN domain-containing protein. (122 aa)
	T1EJQ3_HELRO	AAA_23 domain-containing protein. (137 aa)
	T1EK67_HELRO	Fork-head domain-containing protein. (74 aa)
	T1EK71_HELRO	Fork-head domain-containing protein. (72 aa)
	T1EKM2_HELRO	Helicase ATP-binding domain-containing protein. (181 aa)
	T1EKX3_HELRO	Uncharacterized protein. (91 aa)
	T1ELV7_HELRO	WD_REPEATS_REGION domain-containing protein. (300 aa)
	T1EM64_HELRO	Uncharacterized protein. (599 aa)
	T1EM97_HELRO	Structural maintenance of chromosomes protein. (1222 aa)
	T1ENG1_HELRO	Peptidylprolyl isomerase. (422 aa)
	T1EP55_HELRO	C3H1-type domain-containing protein. (1156 aa)
	T1EP97_HELRO	RRM domain-containing protein. (545 aa)
	T1EPG0_HELRO	Uncharacterized protein. (622 aa)
	T1EQA5_HELRO	JmjC domain-containing protein. (685 aa)
	T1ER96_HELRO	Protein kinase domain-containing protein. (708 aa)
	T1ES65_HELRO	Uncharacterized protein. (408 aa)
	T1ET87_HELRO	SMP-LTD domain-containing protein. (445 aa)
	T1ETZ2_HELRO	Uncharacterized protein. (589 aa)
	T1EVY1_HELRO	Cnd1 domain-containing protein. (218 aa)
	T1EZ80_HELRO	Uncharacterized protein. (487 aa)
	T1EZ81_HELRO	HORMA domain-containing protein. (403 aa)
	T1F0N0_HELRO	Peptidylprolyl isomerase. (452 aa)
	T1F172_HELRO	Zinc-hook domain-containing protein. (1103 aa)
	T1F1B8_HELRO	Uncharacterized protein. (140 aa)
	T1F2J4_HELRO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (254 aa)
	T1F2R7_HELRO	Gamma-tubulin complex component. (679 aa)
	T1F2R8_HELRO	Uncharacterized protein. (229 aa)
	T1F5J4_HELRO	Uncharacterized protein. (377 aa)
	T1F7L5_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	T1F816_HELRO	Tudor domain-containing protein. (458 aa)
	T1F8M1_HELRO	Uncharacterized protein. (756 aa)
	T1F9H9_HELRO	Tyrosine-protein kinase. (558 aa)
	T1F9M4_HELRO	DUF3715 domain-containing protein. (532 aa)
	T1FAN9_HELRO	Uncharacterized protein. (244 aa)
	T1FIB1_HELRO	Gamma-tubulin complex component. (669 aa)
	T1FJ71_HELRO	Protein kinase domain-containing protein. (317 aa)
	T1FJT8_HELRO	Cyclin_C domain-containing protein. (134 aa)
	T1FNP4_HELRO	Uncharacterized protein. (569 aa)
	T1FNV3_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (447 aa)
	T1FP02_HELRO	Checkpoint protein; Belongs to the HUS1 family. (283 aa)
	T1FPE0_HELRO	Ubiquitin-like domain-containing protein. (557 aa)
	T1FPE1_HELRO	Uncharacterized protein. (529 aa)
	T1FPP7_HELRO	Uncharacterized protein. (598 aa)
	T1FR25_HELRO	RING-type domain-containing protein. (268 aa)
	T1FR75_HELRO	Uncharacterized protein. (409 aa)
	T1FR89_HELRO	ERCC4 domain-containing protein. (852 aa)
	T1FRR4_HELRO	Uncharacterized protein. (3542 aa)
	T1FRW1_HELRO	CENP-C_C domain-containing protein. (372 aa)
	T1FRX4_HELRO	Uncharacterized protein. (1919 aa)
	T1FSU8_HELRO	Protein kinase domain-containing protein. (684 aa)
	T1FSY7_HELRO	WD_REPEATS_REGION domain-containing protein. (666 aa)
	T1FT05_HELRO	Peptidase C50 domain-containing protein. (844 aa)
	T1FTI0_HELRO	Gamma-tubulin complex component. (1009 aa)
	T1FTP4_HELRO	Uncharacterized protein. (171 aa)
	T1FTR6_HELRO	Tower domain-containing protein. (3257 aa)
	T1FTS6_HELRO	BUB1 N-terminal domain-containing protein. (1612 aa)
	T1FTT8_HELRO	KIND domain-containing protein. (807 aa)
	T1FTZ4_HELRO	Rad21_Rec8_N domain-containing protein. (557 aa)
	T1FU31_HELRO	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (756 aa)
	T1FUB6_HELRO	Uncharacterized protein. (1337 aa)
	T1FUH3_HELRO	INCENP_ARK-bind domain-containing protein. (1692 aa)
	T1FV59_HELRO	ERCC4 domain-containing protein. (393 aa)
	T1FWH7_HELRO	Uncharacterized protein. (430 aa)
	T1FX52_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
	T1FXE8_HELRO	Uncharacterized protein. (184 aa)
	T1FXU5_HELRO	Uncharacterized protein. (212 aa)
	T1FY54_HELRO	Gamma-tubulin complex component. (593 aa)
	T1FZ58_HELRO	RING-type domain-containing protein. (139 aa)
	T1FZE9_HELRO	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1223 aa)
	T1FZG5_HELRO	Uncharacterized protein. (476 aa)
	T1FZU9_HELRO	RRM domain-containing protein. (122 aa)
	T1G000_HELRO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (253 aa)
	T1G0A3_HELRO	Uncharacterized protein. (190 aa)
	T1G315_HELRO	DNA_MISMATCH_REPAIR_2 domain-containing protein. (645 aa)
	T1G328_HELRO	Uncharacterized protein. (231 aa)
	T1G3Q5_HELRO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (748 aa)
	T1G459_HELRO	Protein kinase domain-containing protein. (220 aa)
	T1G4M0_HELRO	Protein kinase domain-containing protein. (139 aa)
	T1G524_HELRO	TP6A_N domain-containing protein. (297 aa)
	T1G5B7_HELRO	Helicase C-terminal domain-containing protein. (595 aa)
	T1G5T7_HELRO	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa)
	T1G5U1_HELRO	Uncharacterized protein. (282 aa)
	T1G805_HELRO	CENP-C_C domain-containing protein. (218 aa)
	T1G922_HELRO	Uncharacterized protein. (838 aa)
	T1G9P7_HELRO	ERCC4 domain-containing protein. (940 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ECZ1_HELRO	T1F2R7_HELRO	T1ECZ1	T1F2R7	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	Gamma-tubulin complex component.	0.987
T1ECZ1_HELRO	T1F2R8_HELRO	T1ECZ1	T1F2R8	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	Uncharacterized protein.	0.974
T1ECZ1_HELRO	T1FIB1_HELRO	T1ECZ1	T1FIB1	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	Gamma-tubulin complex component.	0.992
T1ECZ1_HELRO	T1FSY7_HELRO	T1ECZ1	T1FSY7	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	WD_REPEATS_REGION domain-containing protein.	0.820
T1ECZ1_HELRO	T1FTI0_HELRO	T1ECZ1	T1FTI0	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	Gamma-tubulin complex component.	0.990
T1ECZ1_HELRO	T1FY54_HELRO	T1ECZ1	T1FY54	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	Gamma-tubulin complex component.	0.999
T1EE44_HELRO	T1EEQ9_HELRO	T1EE44	T1EEQ9	Protein kinase domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.556
T1EE44_HELRO	T1F2J4_HELRO	T1EE44	T1F2J4	Protein kinase domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.556
T1EE44_HELRO	T1FJT8_HELRO	T1EE44	T1FJT8	Protein kinase domain-containing protein.	Cyclin_C domain-containing protein.	0.556
T1EE44_HELRO	T1FT05_HELRO	T1EE44	T1FT05	Protein kinase domain-containing protein.	Peptidase C50 domain-containing protein.	0.498
T1EE44_HELRO	T1FTZ4_HELRO	T1EE44	T1FTZ4	Protein kinase domain-containing protein.	Rad21_Rec8_N domain-containing protein.	0.522
T1EE44_HELRO	T1G3Q5_HELRO	T1EE44	T1G3Q5	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.439
T1EEQ9_HELRO	T1EE44_HELRO	T1EEQ9	T1EE44	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.556
T1EEQ9_HELRO	T1F2J4_HELRO	T1EEQ9	T1F2J4	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.547
T1EEQ9_HELRO	T1FJT8_HELRO	T1EEQ9	T1FJT8	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin_C domain-containing protein.	0.544
T1EEQ9_HELRO	T1FX52_HELRO	T1EEQ9	T1FX52	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.556
T1EEY5_HELRO	T1EKM2_HELRO	T1EEY5	T1EKM2	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.421
T1EEY5_HELRO	T1EKX3_HELRO	T1EEY5	T1EKX3	Uncharacterized protein.	Uncharacterized protein.	0.702
T1EEY5_HELRO	T1EP55_HELRO	T1EEY5	T1EP55	Uncharacterized protein.	C3H1-type domain-containing protein.	0.482
T1EEY5_HELRO	T1EP97_HELRO	T1EEY5	T1EP97	Uncharacterized protein.	RRM domain-containing protein.	0.483