(122 nodes) Ion transport domain network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1EIB6_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (102 aa)
	T1EIH1_HELRO	Ion_trans domain-containing protein. (100 aa)
	T1EIJ2_HELRO	Ion_trans domain-containing protein. (70 aa)
	T1EIU9_HELRO	Ion_trans domain-containing protein. (52 aa)
	T1EJ29_HELRO	Ion_trans domain-containing protein. (346 aa)
	T1EJ30_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (452 aa)
	T1EJR2_HELRO	Ion_trans domain-containing protein. (110 aa)
	T1EJT0_HELRO	Ion_trans domain-containing protein. (152 aa)
	T1EKC2_HELRO	Uncharacterized protein. (1572 aa)
	T1EKD3_HELRO	Uncharacterized protein. (421 aa)
	T1EKP0_HELRO	Ion_trans domain-containing protein. (96 aa)
	T1ELQ3_HELRO	Uncharacterized protein. (1645 aa)
	T1ELX5_HELRO	Ion_trans domain-containing protein. (82 aa)
	T1EM08_HELRO	Ion_trans domain-containing protein. (116 aa)
	T1EMF9_HELRO	Uncharacterized protein. (673 aa)
	T1ENA5_HELRO	Ion_trans domain-containing protein. (217 aa)
	T1EQF1_HELRO	Ion_trans domain-containing protein. (283 aa)
	T1EQH1_HELRO	Ion_trans domain-containing protein. (517 aa)
	T1EQH2_HELRO	Ion_trans domain-containing protein. (394 aa)
	T1EQH3_HELRO	Uncharacterized protein. (625 aa)
	T1ER62_HELRO	Ion_trans domain-containing protein. (325 aa)
	T1ER63_HELRO	Ion_trans domain-containing protein. (261 aa)
	T1ESF0_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (482 aa)
	T1ESI5_HELRO	Uncharacterized protein. (598 aa)
	T1EU74_HELRO	Uncharacterized protein. (1226 aa)
	T1EYX6_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1420 aa)
	T1EZN9_HELRO	Ion_trans domain-containing protein. (268 aa)
	T1EZP0_HELRO	Ion_trans domain-containing protein. (457 aa)
	T1F057_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (528 aa)
	T1F230_HELRO	Ion_trans domain-containing protein. (1134 aa)
	T1F2D4_HELRO	Uncharacterized protein. (2128 aa)
	T1F3E3_HELRO	Uncharacterized protein. (2301 aa)
	T1F8D8_HELRO	Ion_trans domain-containing protein. (649 aa)
	T1F9F9_HELRO	Cyclic nucleotide-binding domain-containing protein. (580 aa)
	T1FPY1_HELRO	Uncharacterized protein. (1259 aa)
	T1EEH6_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (547 aa)
	T1EES7_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (349 aa)
	T1EEX7_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1792 aa)
	T1EFL1_HELRO	Uncharacterized protein. (1102 aa)
	T1EGK4_HELRO	Cyclic nucleotide-binding domain-containing protein. (796 aa)
	T1EGM2_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1864 aa)
	T1EGM4_HELRO	Uncharacterized protein. (1408 aa)
	T1EGN7_HELRO	Uncharacterized protein. (706 aa)
	T1EGN8_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (430 aa)
	T1EGP5_HELRO	Cyclic nucleotide-binding domain-containing protein. (519 aa)
	T1EGR4_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (387 aa)
	T1EGU0_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (269 aa)
	T1EGU8_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (372 aa)
	T1EGV3_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (287 aa)
	T1EGZ0_HELRO	Uncharacterized protein. (302 aa)
	T1EH36_HELRO	Ion_trans domain-containing protein. (226 aa)
	T1EH93_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (155 aa)
	T1EHI1_HELRO	Ion_trans domain-containing protein. (77 aa)
	T1EHL6_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (76 aa)
	T1EHR1_HELRO	Uncharacterized protein. (1602 aa)
	T1EHR2_HELRO	Uncharacterized protein. (677 aa)
	T1EHR3_HELRO	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1563 aa)
	T1EHT1_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (395 aa)
	T1EHT3_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (655 aa)
	T1EHU1_HELRO	Uncharacterized protein. (516 aa)
	T1G432_HELRO	Ion_trans domain-containing protein. (268 aa)
	T1G466_HELRO	Cyclic nucleotide-binding domain-containing protein. (516 aa)
	T1G4C6_HELRO	Uncharacterized protein. (717 aa)
	T1G4M2_HELRO	Cyclic nucleotide-binding domain-containing protein. (491 aa)
	T1G556_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (267 aa)
	T1G582_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (190 aa)
	T1G5A6_HELRO	Uncharacterized protein. (915 aa)
	T1G5I2_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (501 aa)
	T1G616_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (672 aa)
	T1G666_HELRO	Cyclic nucleotide-binding domain-containing protein. (440 aa)
	T1G6J5_HELRO	Cyclic nucleotide-binding domain-containing protein. (553 aa)
	T1G6L3_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (475 aa)
	T1G6L4_HELRO	Ion_trans domain-containing protein. (289 aa)
	T1G6M4_HELRO	Ion_trans domain-containing protein. (99 aa)
	T1G6U4_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (541 aa)
	T1G6U9_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (430 aa)
	T1G7B6_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1792 aa)
	T1G7X6_HELRO	Cyclic nucleotide-binding domain-containing protein. (471 aa)
	T1G821_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (496 aa)
	T1G8I9_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (420 aa)
	T1G8N9_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (226 aa)
	T1G8Y8_HELRO	Uncharacterized protein; Belongs to the potassium channel family. (517 aa)
	T1G9K3_HELRO	Cyclic nucleotide-binding domain-containing protein. (638 aa)
	T1G411_HELRO	Ion_trans domain-containing protein. (205 aa)
	T1G3U9_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (374 aa)
	T1G398_HELRO	Cyclic nucleotide-binding domain-containing protein. (475 aa)
	T1G339_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (645 aa)
	T1G2V1_HELRO	Cyclic nucleotide-binding domain-containing protein. (550 aa)
	T1G2C2_HELRO	Uncharacterized protein; Belongs to the potassium channel family. (622 aa)
	T1G267_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (481 aa)
	T1G1F3_HELRO	Ca_chan_IQ domain-containing protein. (1418 aa)
	T1G161_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (767 aa)
	T1G151_HELRO	Cyclic nucleotide-binding domain-containing protein. (651 aa)
	T1G0W6_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (507 aa)
	T1G0P3_HELRO	Cyclic nucleotide-binding domain-containing protein. (486 aa)
	T1G0H5_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1722 aa)
	T1FZX6_HELRO	Cyclic nucleotide-binding domain-containing protein. (473 aa)
	T1FZJ7_HELRO	Uncharacterized protein. (1616 aa)
	T1FYV9_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (255 aa)
	T1FYV2_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (452 aa)
	T1FYP8_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (805 aa)
	T1FYN9_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (466 aa)
	T1FYK0_HELRO	Uncharacterized protein. (1581 aa)
	T1FYI8_HELRO	Ion_trans domain-containing protein; Belongs to the potassium channel family. (317 aa)
	T1FYE4_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (399 aa)
	T1FXY9_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (491 aa)
	T1FXX2_HELRO	Uncharacterized protein. (1174 aa)
	T1FXW1_HELRO	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1823 aa)
	T1FXP5_HELRO	Cyclic nucleotide-binding domain-containing protein. (504 aa)
	T1FXG5_HELRO	BTB domain-containing protein; Belongs to the potassium channel family. (497 aa)
	T1FXG3_HELRO	Cyclic nucleotide-binding domain-containing protein. (502 aa)
	T1FXF7_HELRO	Ion_trans domain-containing protein. (80 aa)
	T1FXF2_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (967 aa)
	T1FXE0_HELRO	Ion_trans domain-containing protein. (56 aa)
	T1FX70_HELRO	Uncharacterized protein. (1200 aa)
	T1FX16_HELRO	Cyclic nucleotide-binding domain-containing protein. (509 aa)
	T1FVZ2_HELRO	Uncharacterized protein. (1740 aa)
	T1FT85_HELRO	Ion_trans domain-containing protein. (1163 aa)
	T1FSZ8_HELRO	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1071 aa)
	T1FS99_HELRO	Uncharacterized protein. (1621 aa)
	T1FRM4_HELRO	Uncharacterized protein. (1663 aa)
	T1FPB2_HELRO	Uncharacterized protein; Belongs to the potassium channel family. (458 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EEX7_HELRO	T1EGM2_HELRO	T1EEX7	T1EGM2	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.551
T1EEX7_HELRO	T1EGZ0_HELRO	T1EEX7	T1EGZ0	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.547
T1EEX7_HELRO	T1EH36_HELRO	T1EEX7	T1EH36	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.544
T1EEX7_HELRO	T1EH93_HELRO	T1EEX7	T1EH93	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.544
T1EEX7_HELRO	T1EHI1_HELRO	T1EEX7	T1EHI1	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.664
T1EEX7_HELRO	T1EIJ2_HELRO	T1EEX7	T1EIJ2	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.543
T1EEX7_HELRO	T1EIU9_HELRO	T1EEX7	T1EIU9	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.544
T1EEX7_HELRO	T1EJ29_HELRO	T1EEX7	T1EJ29	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.547
T1EEX7_HELRO	T1EJR2_HELRO	T1EEX7	T1EJR2	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.682
T1EEX7_HELRO	T1EKC2_HELRO	T1EEX7	T1EKC2	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.684
T1EEX7_HELRO	T1EM08_HELRO	T1EEX7	T1EM08	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.664
T1EEX7_HELRO	T1F3E3_HELRO	T1EEX7	T1F3E3	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.689
T1EEX7_HELRO	T1FXE0_HELRO	T1EEX7	T1FXE0	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.546
T1EEX7_HELRO	T1FXF7_HELRO	T1EEX7	T1FXF7	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.547
T1EEX7_HELRO	T1FXW1_HELRO	T1EEX7	T1FXW1	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.552
T1EEX7_HELRO	T1FYK0_HELRO	T1EEX7	T1FYK0	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.684
T1EEX7_HELRO	T1G0H5_HELRO	T1EEX7	T1G0H5	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.554
T1EEX7_HELRO	T1G411_HELRO	T1EEX7	T1G411	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.682
T1EEX7_HELRO	T1G432_HELRO	T1EEX7	T1G432	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.685
T1EEX7_HELRO	T1G6L3_HELRO	T1EEX7	T1G6L3	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.551