60 items (Helobdella robusta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1EE23_HELRO	Uncharacterized protein. (354 aa)
	T1EES6_HELRO	BRCT domain-containing protein. (410 aa)
	T1EG24_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
	T1EG29_HELRO	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1066 aa)
	T1EG41_HELRO	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
	T1EHU7_HELRO	Uncharacterized protein. (484 aa)
	T1EJQ3_HELRO	AAA_23 domain-containing protein. (137 aa)
	T1EK81_HELRO	Uncharacterized protein. (116 aa)
	T1EKH9_HELRO	MPN domain-containing protein. (264 aa)
	T1ELD1_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa)
	T1ELH2_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (259 aa)
	T1EM22_HELRO	Uncharacterized protein. (263 aa)
	T1EML4_HELRO	Histone H2B; Belongs to the histone H2B family. (120 aa)
	T1ES65_HELRO	Uncharacterized protein. (408 aa)
	T1EWB9_HELRO	Uncharacterized protein. (159 aa)
	T1F172_HELRO	Zinc-hook domain-containing protein. (1103 aa)
	T1F1B8_HELRO	Uncharacterized protein. (140 aa)
	T1F1C0_HELRO	Uncharacterized protein. (119 aa)
	T1F223_HELRO	ANK_REP_REGION domain-containing protein. (243 aa)
	T1F225_HELRO	Uncharacterized protein. (414 aa)
	T1F5Y5_HELRO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (115 aa)
	T1F5Y6_HELRO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (117 aa)
	T1FCP8_HELRO	Uncharacterized protein. (136 aa)
	T1FHA3_HELRO	Dna2 domain-containing protein. (345 aa)
	T1FHD6_HELRO	Uncharacterized protein. (114 aa)
	T1FHS6_HELRO	Endo/exonuclease/phosphatase domain-containing protein. (229 aa)
	T1FJ72_HELRO	Uncharacterized protein. (185 aa)
	T1FK29_HELRO	Uncharacterized protein. (101 aa)
	T1FMD5_HELRO	AAA domain-containing protein. (333 aa)
	T1FMJ7_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
	T1FMT1_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
	T1FNJ3_HELRO	Histone H2B; Belongs to the histone H2B family. (123 aa)
	T1FNT7_HELRO	AAA domain-containing protein. (355 aa)
	T1FNZ9_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa)
	T1FP02_HELRO	Checkpoint protein; Belongs to the HUS1 family. (283 aa)
	T1FQ99_HELRO	Uncharacterized protein. (408 aa)
	T1FQJ9_HELRO	zf-4CXXC_R1 domain-containing protein. (380 aa)
	T1FQW8_HELRO	Protein kinase domain-containing protein. (579 aa)
	T1FQZ1_HELRO	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (819 aa)
	T1FRW9_HELRO	Uncharacterized protein. (1019 aa)
	T1FS48_HELRO	3'-5' exonuclease domain-containing protein. (531 aa)
	T1FTJ5_HELRO	Uncharacterized protein. (791 aa)
	T1FU31_HELRO	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (756 aa)
	T1FUP2_HELRO	Uncharacterized protein. (418 aa)
	T1FWH7_HELRO	Uncharacterized protein. (430 aa)
	T1FX46_HELRO	Uncharacterized protein. (200 aa)
	T1FXW3_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	T1FZL0_HELRO	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (501 aa)
	T1G0C7_HELRO	Histone domain-containing protein; Belongs to the histone H2B family. (69 aa)
	T1G0D3_HELRO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	T1G1K7_HELRO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
	T1G259_HELRO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (251 aa)
	T1G3M0_HELRO	Histone H2B; Belongs to the histone H2B family. (64 aa)
	T1G3M1_HELRO	Histone H2B; Belongs to the histone H2B family. (49 aa)
	T1G3Q5_HELRO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (748 aa)
	T1G3S1_HELRO	Uncharacterized protein. (309 aa)
	T1G5M3_HELRO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	T1G6W5_HELRO	AAA domain-containing protein. (318 aa)
	T1G8J7_HELRO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	T1G935_HELRO	Uncharacterized protein. (700 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EE23_HELRO	T1EES6_HELRO	T1EE23	T1EES6	Uncharacterized protein.	BRCT domain-containing protein.	0.764
T1EE23_HELRO	T1EG29_HELRO	T1EE23	T1EG29	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.884
T1EE23_HELRO	T1EG41_HELRO	T1EE23	T1EG41	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.892
T1EE23_HELRO	T1EHU7_HELRO	T1EE23	T1EHU7	Uncharacterized protein.	Uncharacterized protein.	0.886
T1EE23_HELRO	T1EJQ3_HELRO	T1EE23	T1EJQ3	Uncharacterized protein.	AAA_23 domain-containing protein.	0.828
T1EE23_HELRO	T1EM22_HELRO	T1EE23	T1EM22	Uncharacterized protein.	Uncharacterized protein.	0.858
T1EE23_HELRO	T1ES65_HELRO	T1EE23	T1ES65	Uncharacterized protein.	Uncharacterized protein.	0.835
T1EE23_HELRO	T1F172_HELRO	T1EE23	T1F172	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.828
T1EE23_HELRO	T1F1B8_HELRO	T1EE23	T1F1B8	Uncharacterized protein.	Uncharacterized protein.	0.773
T1EE23_HELRO	T1F1C0_HELRO	T1EE23	T1F1C0	Uncharacterized protein.	Uncharacterized protein.	0.773
T1EE23_HELRO	T1F223_HELRO	T1EE23	T1F223	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.614
T1EE23_HELRO	T1F225_HELRO	T1EE23	T1F225	Uncharacterized protein.	Uncharacterized protein.	0.614
T1EE23_HELRO	T1FHA3_HELRO	T1EE23	T1FHA3	Uncharacterized protein.	Dna2 domain-containing protein.	0.965
T1EE23_HELRO	T1FHD6_HELRO	T1EE23	T1FHD6	Uncharacterized protein.	Uncharacterized protein.	0.728
T1EE23_HELRO	T1FMD5_HELRO	T1EE23	T1FMD5	Uncharacterized protein.	AAA domain-containing protein.	0.897
T1EE23_HELRO	T1FNT7_HELRO	T1EE23	T1FNT7	Uncharacterized protein.	AAA domain-containing protein.	0.836
T1EE23_HELRO	T1FP02_HELRO	T1EE23	T1FP02	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.899
T1EE23_HELRO	T1FQJ9_HELRO	T1EE23	T1FQJ9	Uncharacterized protein.	zf-4CXXC_R1 domain-containing protein.	0.826
T1EE23_HELRO	T1FQW8_HELRO	T1EE23	T1FQW8	Uncharacterized protein.	Protein kinase domain-containing protein.	0.936
T1EE23_HELRO	T1FQZ1_HELRO	T1EE23	T1FQZ1	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.997