(34 nodes) Tryptophan metabolism network (Helobdella robusta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	T1ED92_HELRO	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
	T1EDA9_HELRO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (472 aa)
	T1EE50_HELRO	Transket_pyr domain-containing protein. (821 aa)
	T1EEF9_HELRO	Aminotran_1_2 domain-containing protein. (425 aa)
	T1EFM2_HELRO	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (490 aa)
	T1EJ26_HELRO	Uncharacterized protein; Belongs to the cytochrome P450 family. (435 aa)
	T1EMF7_HELRO	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
	T1EMK4_HELRO	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	T1EP92_HELRO	Abhydrolase_3 domain-containing protein. (315 aa)
	T1ERL7_HELRO	Uncharacterized protein. (379 aa)
	T1F193_HELRO	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (510 aa)
	T1F8Q1_HELRO	Uncharacterized protein. (377 aa)
	T1FM91_HELRO	Dihydrolipoyl dehydrogenase. (506 aa)
	T1FMR2_HELRO	Uncharacterized protein. (315 aa)
	T1FMR4_HELRO	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (505 aa)
	T1FMU4_HELRO	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (475 aa)
	T1FMW5_HELRO	Amine oxidase. (518 aa)
	T1FN07_HELRO	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (345 aa)
	T1FND8_HELRO	Uncharacterized protein. (314 aa)
	T1FNP3_HELRO	Uncharacterized protein. (472 aa)
	T1FP71_HELRO	Uncharacterized protein. (371 aa)
	T1FPA2_HELRO	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
	T1FPR7_HELRO	Aminotran_1_2 domain-containing protein. (442 aa)
	T1FPR8_HELRO	Aminotran_1_2 domain-containing protein. (451 aa)
	T1FQB2_HELRO	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (495 aa)
	T1FTU4_HELRO	Uncharacterized protein. (382 aa)
	T1FVK5_HELRO	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (523 aa)
	T1FW26_HELRO	Uncharacterized protein. (770 aa)
	T1FYF4_HELRO	Aminotran_1_2 domain-containing protein. (332 aa)
	T1G3Q0_HELRO	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	T1G3S8_HELRO	BH4_AAA_HYDROXYL_2 domain-containing protein. (340 aa)
	T1G421_HELRO	Lipoyl-binding domain-containing protein. (395 aa)
	T1G792_HELRO	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
	T1G9F2_HELRO	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family. (827 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ED92_HELRO	T1EDA9_HELRO	T1ED92	T1EDA9	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.562
T1ED92_HELRO	T1EE50_HELRO	T1ED92	T1EE50	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Transket_pyr domain-containing protein.	0.547
T1ED92_HELRO	T1EMK4_HELRO	T1ED92	T1EMK4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.466
T1ED92_HELRO	T1F193_HELRO	T1ED92	T1F193	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.469
T1ED92_HELRO	T1FMR4_HELRO	T1ED92	T1FMR4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.469
T1ED92_HELRO	T1FMW5_HELRO	T1ED92	T1FMW5	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Amine oxidase.	0.441
T1ED92_HELRO	T1FN07_HELRO	T1ED92	T1FN07	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.960
T1ED92_HELRO	T1FND8_HELRO	T1ED92	T1FND8	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.429
T1ED92_HELRO	T1FP71_HELRO	T1ED92	T1FP71	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.413
T1ED92_HELRO	T1G421_HELRO	T1ED92	T1G421	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Lipoyl-binding domain-containing protein.	0.413
T1ED92_HELRO	T1G792_HELRO	T1ED92	T1G792	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.466
T1EDA9_HELRO	T1ED92_HELRO	T1EDA9	T1ED92	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.562
T1EDA9_HELRO	T1EEF9_HELRO	T1EDA9	T1EEF9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.961
T1EDA9_HELRO	T1EFM2_HELRO	T1EDA9	T1EFM2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.565
T1EDA9_HELRO	T1EJ26_HELRO	T1EDA9	T1EJ26	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.463
T1EDA9_HELRO	T1EMF7_HELRO	T1EDA9	T1EMF7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.521
T1EDA9_HELRO	T1EP92_HELRO	T1EDA9	T1EP92	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Abhydrolase_3 domain-containing protein.	0.977
T1EDA9_HELRO	T1ERL7_HELRO	T1EDA9	T1ERL7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.942
T1EDA9_HELRO	T1FMR2_HELRO	T1EDA9	T1FMR2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.894
T1EDA9_HELRO	T1FMU4_HELRO	T1EDA9	T1FMU4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.737