(37 nodes) Amino sugar and nucleotide sugar metabolism network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1ED41_HELRO	NAD(P)-bd_dom domain-containing protein. (374 aa)
	T1EDP1_HELRO	Uncharacterized protein. (603 aa)
	T1EDV8_HELRO	Phosphotransferase. (445 aa)
	T1EE59_HELRO	NTP_transferase domain-containing protein. (360 aa)
	T1EEQ4_HELRO	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (442 aa)
	T1EES0_HELRO	Glucose-6-phosphate isomerase; Belongs to the GPI family. (559 aa)
	T1EFX3_HELRO	Uncharacterized protein. (703 aa)
	T1EGC6_HELRO	Uncharacterized protein. (466 aa)
	T1EIZ6_HELRO	Glyco_hydro_20 domain-containing protein. (391 aa)
	T1EMB4_HELRO	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (231 aa)
	T1EMG1_HELRO	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (371 aa)
	T1EY64_HELRO	Mannose-6-phosphate isomerase. (424 aa)
	T1F730_HELRO	Chitin-binding type-2 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (828 aa)
	T1FH77_HELRO	Uncharacterized protein. (1032 aa)
	T1FI44_HELRO	Uncharacterized protein. (941 aa)
	T1FM35_HELRO	Uncharacterized protein. (511 aa)
	T1FMY3_HELRO	Epimerase domain-containing protein. (319 aa)
	T1FN59_HELRO	NTP_transferase domain-containing protein. (481 aa)
	T1FNC4_HELRO	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (303 aa)
	T1FNY0_HELRO	BcrAD_BadFG domain-containing protein. (369 aa)
	T1FP09_HELRO	Glucosamine-6-phosphate isomerase. (274 aa)
	T1FP13_HELRO	UTP--glucose-1-phosphate uridylyltransferase. (484 aa)
	T1FP42_HELRO	Uncharacterized protein; Belongs to the phosphohexose mutase family. (560 aa)
	T1FRW7_HELRO	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (248 aa)
	T1FST5_HELRO	NAD(P)-bd_dom domain-containing protein. (382 aa)
	T1FU87_HELRO	Uncharacterized protein. (432 aa)
	T1FUZ2_HELRO	CHB_HEX domain-containing protein. (1540 aa)
	T1FWV2_HELRO	Uncharacterized protein. (754 aa)
	T1FYY1_HELRO	Fucokinase domain-containing protein. (555 aa)
	T1FZI3_HELRO	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (193 aa)
	T1G247_HELRO	NAD(P)-bd_dom domain-containing protein. (337 aa)
	T1G2G4_HELRO	Uncharacterized protein. (1028 aa)
	T1G407_HELRO	Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (363 aa)
	T1G427_HELRO	Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (375 aa)
	T1G513_HELRO	Uncharacterized protein. (391 aa)
	T1G6J7_HELRO	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (544 aa)
	T1G7R3_HELRO	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (491 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ED41_HELRO	T1EDP1_HELRO	T1ED41	T1EDP1	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.659
T1ED41_HELRO	T1EE59_HELRO	T1ED41	T1EE59	NAD(P)-bd_dom domain-containing protein.	NTP_transferase domain-containing protein.	0.986
T1ED41_HELRO	T1EES0_HELRO	T1ED41	T1EES0	NAD(P)-bd_dom domain-containing protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.618
T1ED41_HELRO	T1EFX3_HELRO	T1ED41	T1EFX3	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.500
T1ED41_HELRO	T1EMG1_HELRO	T1ED41	T1EMG1	NAD(P)-bd_dom domain-containing protein.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.779
T1ED41_HELRO	T1EY64_HELRO	T1ED41	T1EY64	NAD(P)-bd_dom domain-containing protein.	Mannose-6-phosphate isomerase.	0.731
T1ED41_HELRO	T1FH77_HELRO	T1ED41	T1FH77	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.709
T1ED41_HELRO	T1FM35_HELRO	T1ED41	T1FM35	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.552
T1ED41_HELRO	T1FMY3_HELRO	T1ED41	T1FMY3	NAD(P)-bd_dom domain-containing protein.	Epimerase domain-containing protein.	0.997
T1ED41_HELRO	T1FN59_HELRO	T1ED41	T1FN59	NAD(P)-bd_dom domain-containing protein.	NTP_transferase domain-containing protein.	0.971
T1ED41_HELRO	T1FST5_HELRO	T1ED41	T1FST5	NAD(P)-bd_dom domain-containing protein.	NAD(P)-bd_dom domain-containing protein.	0.721
T1ED41_HELRO	T1FWV2_HELRO	T1ED41	T1FWV2	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.500
T1ED41_HELRO	T1FYY1_HELRO	T1ED41	T1FYY1	NAD(P)-bd_dom domain-containing protein.	Fucokinase domain-containing protein.	0.617
T1ED41_HELRO	T1FZI3_HELRO	T1ED41	T1FZI3	NAD(P)-bd_dom domain-containing protein.	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.	0.572
T1ED41_HELRO	T1G247_HELRO	T1ED41	T1G247	NAD(P)-bd_dom domain-containing protein.	NAD(P)-bd_dom domain-containing protein.	0.721
T1ED41_HELRO	T1G6J7_HELRO	T1ED41	T1G6J7	NAD(P)-bd_dom domain-containing protein.	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.	0.679
T1ED41_HELRO	T1G7R3_HELRO	T1ED41	T1G7R3	NAD(P)-bd_dom domain-containing protein.	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.708
T1EDP1_HELRO	T1ED41_HELRO	T1EDP1	T1ED41	Uncharacterized protein.	NAD(P)-bd_dom domain-containing protein.	0.659
T1EDP1_HELRO	T1EDV8_HELRO	T1EDP1	T1EDV8	Uncharacterized protein.	Phosphotransferase.	0.971
T1EDP1_HELRO	T1EE59_HELRO	T1EDP1	T1EE59	Uncharacterized protein.	NTP_transferase domain-containing protein.	0.768