(19 nodes) Terpenoid backbone biosynthesis network (Helobdella robusta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	T1ED11_HELRO	3-hydroxy-3-methylglutaryl coenzyme A reductase. (932 aa)
	T1EDV4_HELRO	Protein-S-isoprenylcysteine O-methyltransferase. (274 aa)
	T1EE58_HELRO	Abhydrolase_3 domain-containing protein. (361 aa)
	T1EF39_HELRO	Uncharacterized protein. (320 aa)
	T1EFC0_HELRO	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (316 aa)
	T1EG91_HELRO	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (344 aa)
	T1EMF5_HELRO	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (295 aa)
	T1EMK4_HELRO	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	T1EY95_HELRO	Uncharacterized protein. (190 aa)
	T1FMH1_HELRO	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (406 aa)
	T1FMP5_HELRO	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (510 aa)
	T1FMY5_HELRO	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (422 aa)
	T1FN86_HELRO	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (411 aa)
	T1FUG3_HELRO	Uncharacterized protein. (279 aa)
	T1FX17_HELRO	Alkyl transferase; Belongs to the UPP synthase family. (277 aa)
	T1G0E5_HELRO	Uncharacterized protein. (207 aa)
	T1G0L7_HELRO	Nudix hydrolase domain-containing protein. (228 aa)
	T1G1F8_HELRO	GHMP_kinases_N domain-containing protein. (187 aa)
	T1G792_HELRO	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1ED11_HELRO	T1EFC0_HELRO	T1ED11	T1EFC0	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.548
T1ED11_HELRO	T1EG91_HELRO	T1ED11	T1EG91	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.771
T1ED11_HELRO	T1EMF5_HELRO	T1ED11	T1EMF5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.759
T1ED11_HELRO	T1EMK4_HELRO	T1ED11	T1EMK4	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.625
T1ED11_HELRO	T1EY95_HELRO	T1ED11	T1EY95	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.606
T1ED11_HELRO	T1FMH1_HELRO	T1ED11	T1FMH1	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.779
T1ED11_HELRO	T1FMP5_HELRO	T1ED11	T1FMP5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
T1ED11_HELRO	T1FMY5_HELRO	T1ED11	T1FMY5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.548
T1ED11_HELRO	T1FN86_HELRO	T1ED11	T1FN86	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.578
T1ED11_HELRO	T1FUG3_HELRO	T1ED11	T1FUG3	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.572
T1ED11_HELRO	T1FX17_HELRO	T1ED11	T1FX17	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.572
T1ED11_HELRO	T1G0L7_HELRO	T1ED11	T1G0L7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Nudix hydrolase domain-containing protein.	0.867
T1ED11_HELRO	T1G1F8_HELRO	T1ED11	T1G1F8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	GHMP_kinases_N domain-containing protein.	0.990
T1ED11_HELRO	T1G792_HELRO	T1ED11	T1G792	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.625
T1EDV4_HELRO	T1EF39_HELRO	T1EDV4	T1EF39	Protein-S-isoprenylcysteine O-methyltransferase.	Uncharacterized protein.	0.674
T1EDV4_HELRO	T1FMH1_HELRO	T1EDV4	T1FMH1	Protein-S-isoprenylcysteine O-methyltransferase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.479
T1EDV4_HELRO	T1FN86_HELRO	T1EDV4	T1FN86	Protein-S-isoprenylcysteine O-methyltransferase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.674
T1EDV4_HELRO	T1G0E5_HELRO	T1EDV4	T1G0E5	Protein-S-isoprenylcysteine O-methyltransferase.	Uncharacterized protein.	0.971
T1EE58_HELRO	T1G0E5_HELRO	T1EE58	T1G0E5	Abhydrolase_3 domain-containing protein.	Uncharacterized protein.	0.901
T1EF39_HELRO	T1EDV4_HELRO	T1EF39	T1EDV4	Uncharacterized protein.	Protein-S-isoprenylcysteine O-methyltransferase.	0.674