(37 nodes) Proteasome network (Helobdella robusta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1EDG5_HELRO	PCI domain-containing protein. (389 aa)
	T1EDH9_HELRO	Proteasome subunit beta. (282 aa)
	T1EE33_HELRO	Proteasome subunit alpha type. (247 aa)
	T1EFQ2_HELRO	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (909 aa)
	T1EFW7_HELRO	Uncharacterized protein. (2045 aa)
	T1EKI3_HELRO	Proteasome subunit alpha type. (232 aa)
	T1ELJ7_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (401 aa)
	T1ELQ4_HELRO	Proteasome subunit beta. (197 aa)
	T1ELT0_HELRO	Uncharacterized protein. (214 aa)
	T1ELX3_HELRO	PCI domain-containing protein. (381 aa)
	T1ELY7_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (436 aa)
	T1EYD7_HELRO	Proteasome subunit beta. (204 aa)
	T1FM20_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
	T1FML3_HELRO	Proteasome subunit alpha type. (255 aa)
	T1FMU3_HELRO	PCI domain-containing protein. (454 aa)
	T1FMV8_HELRO	Proteasome subunit alpha type. (252 aa)
	T1FN04_HELRO	Uncharacterized protein. (276 aa)
	T1FN26_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
	T1FN40_HELRO	MPN domain-containing protein. (311 aa)
	T1FN63_HELRO	Proteasome subunit alpha type. (242 aa)
	T1FND1_HELRO	Proteasome subunit beta. (205 aa)
	T1FNM4_HELRO	Uncharacterized protein. (261 aa)
	T1FNP8_HELRO	PCI domain-containing protein. (495 aa)
	T1FP84_HELRO	PCI domain-containing protein. (419 aa)
	T1FPT8_HELRO	PCI domain-containing protein. (273 aa)
	T1FY97_HELRO	Proteasome subunit beta; Belongs to the peptidase T1B family. (282 aa)
	T1FYB4_HELRO	Uncharacterized protein. (153 aa)
	T1FZL8_HELRO	PDZ domain-containing protein. (185 aa)
	T1FZV4_HELRO	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (311 aa)
	T1G0S8_HELRO	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
	T1G2I5_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (408 aa)
	T1G3M6_HELRO	VWFA domain-containing protein. (382 aa)
	T1G4Q2_HELRO	AAA domain-containing protein; Belongs to the AAA ATPase family. (374 aa)
	T1G4R9_HELRO	RPN13_C domain-containing protein. (375 aa)
	T1G548_HELRO	Proteasome subunit beta. (245 aa)
	T1G7X9_HELRO	Proteasome subunit beta. (203 aa)
	T1G9Q0_HELRO	MPN domain-containing protein. (336 aa)

Your Current Organism:

Helobdella robusta

NCBI taxonomy Id: 6412
Other names: H. robusta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1EDG5_HELRO	T1EDH9_HELRO	T1EDG5	T1EDH9	PCI domain-containing protein.	Proteasome subunit beta.	0.977
T1EDG5_HELRO	T1EE33_HELRO	T1EDG5	T1EE33	PCI domain-containing protein.	Proteasome subunit alpha type.	0.998
T1EDG5_HELRO	T1EFQ2_HELRO	T1EDG5	T1EFQ2	PCI domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
T1EDG5_HELRO	T1EFW7_HELRO	T1EDG5	T1EFW7	PCI domain-containing protein.	Uncharacterized protein.	0.798
T1EDG5_HELRO	T1EKI3_HELRO	T1EDG5	T1EKI3	PCI domain-containing protein.	Proteasome subunit alpha type.	0.998
T1EDG5_HELRO	T1ELJ7_HELRO	T1EDG5	T1ELJ7	PCI domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
T1EDG5_HELRO	T1ELQ4_HELRO	T1EDG5	T1ELQ4	PCI domain-containing protein.	Proteasome subunit beta.	0.972
T1EDG5_HELRO	T1ELT0_HELRO	T1EDG5	T1ELT0	PCI domain-containing protein.	Uncharacterized protein.	0.997
T1EDG5_HELRO	T1ELX3_HELRO	T1EDG5	T1ELX3	PCI domain-containing protein.	PCI domain-containing protein.	0.999
T1EDG5_HELRO	T1ELY7_HELRO	T1EDG5	T1ELY7	PCI domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
T1EDG5_HELRO	T1EYD7_HELRO	T1EDG5	T1EYD7	PCI domain-containing protein.	Proteasome subunit beta.	0.998
T1EDG5_HELRO	T1FM20_HELRO	T1EDG5	T1FM20	PCI domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
T1EDG5_HELRO	T1FML3_HELRO	T1EDG5	T1FML3	PCI domain-containing protein.	Proteasome subunit alpha type.	0.998
T1EDG5_HELRO	T1FMU3_HELRO	T1EDG5	T1FMU3	PCI domain-containing protein.	PCI domain-containing protein.	0.999
T1EDG5_HELRO	T1FMV8_HELRO	T1EDG5	T1FMV8	PCI domain-containing protein.	Proteasome subunit alpha type.	0.996
T1EDG5_HELRO	T1FN04_HELRO	T1EDG5	T1FN04	PCI domain-containing protein.	Uncharacterized protein.	0.638
T1EDG5_HELRO	T1FN26_HELRO	T1EDG5	T1FN26	PCI domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
T1EDG5_HELRO	T1FN40_HELRO	T1EDG5	T1FN40	PCI domain-containing protein.	MPN domain-containing protein.	0.999
T1EDG5_HELRO	T1FN63_HELRO	T1EDG5	T1FN63	PCI domain-containing protein.	Proteasome subunit alpha type.	0.999
T1EDG5_HELRO	T1FND1_HELRO	T1EDG5	T1FND1	PCI domain-containing protein.	Proteasome subunit beta.	0.996