(18 nodes) mRNA cis splicing, via spliceosome network (Anabas testudineus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wbp11	WW domain binding protein 11. (735 aa)
	dnajc8	DnaJ (Hsp40) homolog, subfamily C, member 8. (250 aa)
	prpf4b	Pre-mRNA processing factor 4Bb. (1017 aa)
	snrpc	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (148 aa)
	ncbp2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
	ENSATEP00000030753	Splicing factor 3a, subunit 1. (840 aa)
	sfswap	Splicing factor SWAP. (975 aa)
	prpf40a	PRP40 pre-mRNA processing factor 40 homolog A. (879 aa)
	LOC113160139	Uncharacterized protein. (330 aa)
	ENSATEP00000000818	PRP39 pre-mRNA processing factor 39 homolog (yeast). (815 aa)
	rbm17	RNA binding motif protein 17. (421 aa)
	rbm22	RNA binding motif protein 22. (427 aa)
	PSIP1	PC4 and SFRS1 interacting protein 1. (509 aa)
	sart1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (770 aa)
	LOC113160627	Si:ch211-114c17.1. (725 aa)
	ENSATEP00000025112	Uncharacterized protein. (350 aa)
	cwc15	CWC15 spliceosome associated protein homolog. (239 aa)
	cactin	Cactin. (859 aa)

Your Current Organism:

Anabas testudineus

NCBI taxonomy Id: 64144
Other names: A. testudineus, Amphiprion testudineus, Anthias testudineus, Antias testudineus, climbing perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSATEP00000000818	ENSATEP00000030753	ENSATEP00000000818	ENSATEP00000030753	PRP39 pre-mRNA processing factor 39 homolog (yeast).	Splicing factor 3a, subunit 1.	0.649
ENSATEP00000000818	ncbp2	ENSATEP00000000818	ENSATEP00000031397	PRP39 pre-mRNA processing factor 39 homolog (yeast).	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.900
ENSATEP00000000818	sart1	ENSATEP00000000818	ENSATEP00000015221	PRP39 pre-mRNA processing factor 39 homolog (yeast).	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.887
ENSATEP00000000818	snrpc	ENSATEP00000000818	ENSATEP00000036568	PRP39 pre-mRNA processing factor 39 homolog (yeast).	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...]	0.934
ENSATEP00000025112	ENSATEP00000030753	ENSATEP00000025112	ENSATEP00000030753	Uncharacterized protein.	Splicing factor 3a, subunit 1.	0.883
ENSATEP00000025112	cwc15	ENSATEP00000025112	ENSATEP00000019115	Uncharacterized protein.	CWC15 spliceosome associated protein homolog.	0.402
ENSATEP00000025112	prpf4b	ENSATEP00000025112	ENSATEP00000000114	Uncharacterized protein.	Pre-mRNA processing factor 4Bb.	0.403
ENSATEP00000025112	rbm22	ENSATEP00000025112	ENSATEP00000011883	Uncharacterized protein.	RNA binding motif protein 22.	0.476
ENSATEP00000025112	sart1	ENSATEP00000025112	ENSATEP00000015221	Uncharacterized protein.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.933
ENSATEP00000025112	snrpc	ENSATEP00000025112	ENSATEP00000036568	Uncharacterized protein.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...]	0.554
ENSATEP00000025112	wbp11	ENSATEP00000025112	ENSATEP00000014717	Uncharacterized protein.	WW domain binding protein 11.	0.787
ENSATEP00000030753	ENSATEP00000000818	ENSATEP00000030753	ENSATEP00000000818	Splicing factor 3a, subunit 1.	PRP39 pre-mRNA processing factor 39 homolog (yeast).	0.649
ENSATEP00000030753	ENSATEP00000025112	ENSATEP00000030753	ENSATEP00000025112	Splicing factor 3a, subunit 1.	Uncharacterized protein.	0.883
ENSATEP00000030753	LOC113160627	ENSATEP00000030753	ENSATEP00000020119	Splicing factor 3a, subunit 1.	Si:ch211-114c17.1.	0.649
ENSATEP00000030753	cwc15	ENSATEP00000030753	ENSATEP00000019115	Splicing factor 3a, subunit 1.	CWC15 spliceosome associated protein homolog.	0.947
ENSATEP00000030753	dnajc8	ENSATEP00000030753	ENSATEP00000012556	Splicing factor 3a, subunit 1.	DnaJ (Hsp40) homolog, subfamily C, member 8.	0.492
ENSATEP00000030753	ncbp2	ENSATEP00000030753	ENSATEP00000031397	Splicing factor 3a, subunit 1.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.989
ENSATEP00000030753	prpf40a	ENSATEP00000030753	ENSATEP00000028506	Splicing factor 3a, subunit 1.	PRP40 pre-mRNA processing factor 40 homolog A.	0.850
ENSATEP00000030753	rbm17	ENSATEP00000030753	ENSATEP00000006269	Splicing factor 3a, subunit 1.	RNA binding motif protein 17.	0.945
ENSATEP00000030753	rbm22	ENSATEP00000030753	ENSATEP00000011883	Splicing factor 3a, subunit 1.	RNA binding motif protein 22.	0.940