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| | Daes_3341 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | Daes_0012 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: tte:TTE0770 NCAIR mutase (PurE)-related proteins. (261 aa) |
| | Daes_0043 | KEGG: dsa:Desal_1478 phosphate butyryltransferase; PFAM: phosphate acetyl/butaryl transferase. (320 aa) |
| | Daes_0074 | PFAM: Nucleotidyl transferase; KEGG: dma:DMR_p1_00350 nucleotidyl transferase domain protein. (245 aa) |
| | Daes_0075 | PFAM: GHMP kinase; GHMP kinase domain protein; KEGG: dma:DMR_p1_00290 putative galactokinase/mevalonate kinase. (354 aa) |
| | fcl | NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (308 aa) |
| | Daes_0103 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: dde:Dde_3686 NAD-dependent epimerase/dehydratase family protein. (298 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (182 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | Daes_0275 | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (244 aa) |
| | Daes_0377 | DNA-directed DNA polymerase; KEGG: dma:DMR_28930 UmuC protein; PFAM: UMUC domain protein DNA-repair protein. (426 aa) |
| | Daes_0413 | KEGG: dau:Daud_1318 hypothetical protein. (184 aa) |
| | Daes_0426 | KEGG: dvl:Dvul_2777 hypothetical protein. (893 aa) |
| | Daes_0479 | KEGG: dds:Ddes_2235 hypothetical protein. (493 aa) |
| | coaX | Transcriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (256 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | Daes_0535 | KEGG: bja:blr3694 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | Daes_0542 | PFAM: AMP-dependent synthetase and ligase; KEGG: dvu:DVU2250 AMP-binding protein. (545 aa) |
| | Daes_0612 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: dsa:Desal_3346 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (126 aa) |
| | Daes_0614 | DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: dsa:Desal_3345 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1173 aa) |
| | Daes_0665 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa) |
| | Daes_0720 | PFAM: CinA domain protein; KEGG: alv:Alvin_1664 CinA domain protein; Belongs to the CinA family. (161 aa) |
| | Daes_0724 | SMART: metal-dependent phosphohydrolase HD region; KEGG: dvl:Dvul_0799 metal dependent phosphohydrolase. (204 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (234 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (998 aa) |
| | hldD | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (326 aa) |
| | Daes_0839 | KEGG: dma:DMR_42310 RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (199 aa) |
| | Daes_0874 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: dsa:Desal_2931 riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; Belongs to the ribF family. (332 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (439 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | Daes_0905 | GCN5-related N-acetyltransferase; KEGG: cpb:Cphamn1_0760 putative anti-sigma regulatory factor, serine/threonine protein kinase; PFAM: GCN5-related N-acetyltransferase; SMART: ATP-binding region ATPase domain protein. (514 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa) |
| | Daes_1049 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: dsa:Desal_1457 IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region. (424 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | Daes_1072 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (705 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | Daes_1110 | Manually curated; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; KEGG: dsa:Desal_0939 transcriptional regulator, LuxR family; PFAM: sigma-70 region 4 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | Daes_1144 | Trimethylamine-N-oxide reductase (cytochrome c); KEGG: dvm:DvMF_1245 molybdopterin oxidoreductase; PFAM: molybdopterin oxidoreductase; glutamine amidotransferase class-I; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (896 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (470 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: dsa:Desal_2171 carbamoyl-phosphate synthase, large subunit; SMART: MGS domain protein; Belongs to the CarB family. (1078 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa) |
| | Daes_1211 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD-binding domain protein; KEGG: dde:Dde_0057 dihydroorotate oxidase B, electron transfer subunit. (261 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (305 aa) |
| | Daes_1226 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (481 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: dsa:Desal_2021 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (298 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (249 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (788 aa) |
| | Daes_1275 | KEGG: tbi:Tbis_1432 adenosine deaminase; PFAM: adenosine/AMP deaminase. (294 aa) |
| | Daes_1284 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: hya:HY04AAS1_1611 NAD-dependent epimerase/dehydratase. (319 aa) |
| | Daes_1285 | PFAM: 2-phosphosulfolactate phosphatase; KEGG: dma:DMR_44220 2-phosphosulfolactate phosphatase family protein; Belongs to the ComB family. (239 aa) |
| | Daes_1317 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (293 aa) |
| | Daes_1362 | RNA polymerase sigma factor, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (261 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (78 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (372 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (160 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (654 aa) |
| | Daes_1451 | PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region; KEGG: dsa:Desal_2328 acetyl-CoA carboxylase. (748 aa) |
| | Daes_1452 | KEGG: dsa:Desal_2327 pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein. (472 aa) |
| | Daes_1454 | CHASE2 domain protein; KEGG: dma:DMR_40230 putative adenylate cyclase; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (741 aa) |
| | Daes_1468 | KEGG: dsa:Desal_2262 phosphoribosylformylglycinamidine synthase. (271 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa) |
| | Daes_1475 | RNA polymerase sigma-54 factor, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (468 aa) |
| | Daes_1495 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (249 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa) |
| | Daes_3345 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: dsa:Desal_3834 NAD-dependent epimerase/dehydratase. (335 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (590 aa) |
| | rpoD | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (581 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | Daes_1520 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (152 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa) |
| | Daes_1584 | KEGG: deg:DehalGT_0233 hypothetical protein. (700 aa) |
| | Daes_1586 | KEGG: dde:Dde_1928 sigma-24 (FecI-like); TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein. (194 aa) |
| | Daes_1593 | PFAM: DNA primase catalytic core domain; KEGG: sfu:Sfum_3790 DNA primase catalytic core. (1104 aa) |
| | Daes_1626 | KEGG: dde:Dde_1885 hypothetical protein. (103 aa) |
| | Daes_1717 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: dsa:Desal_1976 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (289 aa) |
| | Daes_1718 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (345 aa) |
| | Daes_1719 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (533 aa) |
| | Daes_1737 | TIGRFAM: nucleotide sugar dehydrogenase; KEGG: dde:Dde_2042 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation. (445 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (172 aa) |
| | Daes_1977 | Cytidyltransferase-related domain protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (507 aa) |
| | Daes_1983 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: lic:LIC12176 UDP-glucose 4-epimerase. (336 aa) |
| | Daes_2007 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: dsa:Desal_1158 IMP cyclohydrolase; SMART: MGS domain protein. (198 aa) |
| | Daes_2015 | TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; KEGG: dsa:Desal_1150 ATPase, FliI/YscN family; SMART: AAA ATPase. (475 aa) |
| | Daes_2080 | KEGG: dvl:Dvul_1016 acetyl-CoA carboxylase; PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region. (755 aa) |
| | Daes_2081 | Pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: dma:DMR_12700 acetyl-CoA carboxylase biotin carboxylase subunit; SMART: biotin carboxylase domain protein. (472 aa) |
| | Daes_2107 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa) |
| | Daes_2112 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: dsa:Desal_0291 metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (374 aa) |
| | nadK-2 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (293 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (466 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (244 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (346 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1382 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1367 aa) |
| | nusG | Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (185 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (246 aa) |
| | carA | KEGG: dma:DMR_20320 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (374 aa) |
| | Daes_2282 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: dvm:DvMF_2358 fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (492 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (213 aa) |
| | coaE | Pseudouridine synthase, RluA family; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (596 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (514 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (218 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (887 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa) |
| | Daes_2508 | KEGG: dsa:Desal_3228 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | Daes_2545 | Phosphoribulokinase; KEGG: min:Minf_1261 phosphoribulokinase. (308 aa) |
| | Daes_2670 | Adenylate cyclase; KEGG: dsa:Desal_0704 putative adenylate cyclase; PFAM: adenylate cyclase class-I; pentapeptide repeat protein. (1291 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: dsa:Desal_3132 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (353 aa) |
| | nusB | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (151 aa) |
| | Daes_2826 | PFAM: DNA polymerase III delta; KEGG: dsa:Desal_0648 DNA polymerase III delta. (330 aa) |
| | Daes_2870 | KEGG: sfu:Sfum_3887 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (201 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (392 aa) |
| | Daes_3011 | KEGG: dba:Dbac_0141 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (179 aa) |
| | cmk | TIGRFAM: cytidylate kinase; KEGG: dsa:Desal_0177 cytidylate kinase; PFAM: cytidylate kinase region; shikimate kinase. (220 aa) |
| | Daes_3048 | PFAM: DRTGG domain protein; KEGG: dsa:Desal_3001 DRTGG domain protein. (354 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (458 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (465 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (183 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (190 aa) |
| | atpF-2 | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (140 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (102 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (240 aa) |
| | Daes_3129 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: dsa:Desal_3658 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | Daes_3133 | RNA polymerase sigma factor, sigma-70 family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (397 aa) |
| | Daes_3151 | KEGG: dsa:Desal_0283 hypothetical protein. (396 aa) |
| | Daes_3153 | PFAM: SMC domain protein; KEGG: ana:alr0507 hypothetical protein. (395 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (427 aa) |
| | pyrB | KEGG: dsa:Desal_0017 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa) |
| | Daes_3218 | KEGG: rxy:Rxyl_1598 hypothetical protein. (365 aa) |
| | Daes_3227 | KEGG: dat:HRM2_43520 RsbW; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (141 aa) |
| | Daes_3247 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: dat:HRM2_38010 CoxL. (769 aa) |
| | Daes_3249 | PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: dat:HRM2_37990 two-component fusion protein (N:molybdopterin dehydrogenase, FAD-binding domain-C:carbon monoxide dehydrogenase medium chain). (282 aa) |
| | Daes_3270 | KEGG: slt:Slit_2897 dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 35-epimerase related. (183 aa) |
| | Daes_3275 | KEGG: dol:Dole_1963 NAD-dependent epimerase/dehydratase; manually curated; PFAM: NAD-dependent epimerase/dehydratase. (282 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (556 aa) |
| | Daes_3320 | SMART: DNA polymerase III beta chain; TIGRFAM: DNA polymerase III, beta subunit; KEGG: dsa:Desal_3784 DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta chain. (389 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (425 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (364 aa) |
