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| | Daes_1151 | FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; manually curated; KEGG: dvm:DvMF_1310 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (409 aa) |
| | Daes_3323 | PFAM: aminotransferase class IV; KEGG: dsa:Desal_1100 aminotransferase class IV. (256 aa) |
| | Daes_3322 | PFAM: protein of unknown function DUF39; KEGG: dvm:DvMF_1464 protein of unknown function DUF39. (389 aa) |
| | Daes_3309 | KEGG: dsa:Desal_3603 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase. (654 aa) |
| | Daes_3284 | TIGRFAM: glutamine synthetase, type I; KEGG: dsa:Desal_3792 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (447 aa) |
| | Daes_3239 | KEGG: ppd:Ppro_1523 phosphopantetheine-binding. (77 aa) |
| | Daes_3175 | KEGG: dds:Ddes_2008 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | Daes_3167 | PFAM: Acyl transferase; KEGG: dsa:Desal_3757 acyl transferase. (308 aa) |
| | Daes_3166 | TIGRFAM: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; KEGG: cag:Cagg_1999 hexapaptide repeat-containing transferase. (205 aa) |
| | Daes_3151 | KEGG: dsa:Desal_0283 hypothetical protein. (396 aa) |
| | Daes_3132 | PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: dsa:Desal_3661 homocysteine S-methyltransferase. (803 aa) |
| | Daes_3130 | PFAM: GCN5-related N-acetyltransferase; KEGG: dde:Dde_2113 acetyltransferase; Belongs to the acetyltransferase family. (152 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (413 aa) |
| | Daes_3077 | KEGG: dma:DMR_20900 selenide, water dikinase; TIGRFAM: selenide, water dikinase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (318 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (292 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | hisC | KEGG: dsa:Desal_0178 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | Daes_2928 | PFAM: ferredoxin-dependent glutamate synthase; KEGG: dsa:Desal_3587 ferredoxin-dependent glutamate synthase. (541 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (396 aa) |
| | Daes_2863 | PFAM: acyl-ACP thioesterase; KEGG: srm:SRM_00055 acyl-ACP thioesterase. (257 aa) |
| | Daes_2857 | KEGG: dat:HRM2_37910 HisC3; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II. (377 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (335 aa) |
| | Daes_2796 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Daes_2794 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | Daes_2738 | Manually curated; PFAM: Radical SAM domain protein; KEGG: dsa:Desal_3127 radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (420 aa) |
| | Daes_2676 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa) |
| | metE | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (761 aa) |
| | hisB | KEGG: dsa:Desal_1555 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: dsa:Desal_1557 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (244 aa) |
| | Daes_2365 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: chy:CHY_2698 D-3-phosphoglycerate dehydrogenase. (394 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | Daes_2350 | KEGG: dsa:Desal_2862 cysteine synthase; TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia. (771 aa) |
| | Daes_2330 | PFAM: alpha/beta hydrolase fold; KEGG: dde:Dde_1531 hypothetical protein. (326 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (279 aa) |
| | Daes_2300 | KEGG: dsa:Desal_2803 iron-sulfur cluster-binding protein, putative. (517 aa) |
| | carA | KEGG: dma:DMR_20320 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (374 aa) |
| | Daes_2212 | Aldehyde Dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1004 aa) |
| | Daes_2206 | KEGG: dsa:Desal_1240 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (389 aa) |
| | Daes_2204 | KEGG: dba:Dbac_2391 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (397 aa) |
| | Daes_2192 | KEGG: dvm:DvMF_3117 hypothetical protein. (179 aa) |
| | mtnA | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (346 aa) |
| | Daes_2081 | Pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: dma:DMR_12700 acetyl-CoA carboxylase biotin carboxylase subunit; SMART: biotin carboxylase domain protein. (472 aa) |
| | Daes_2080 | KEGG: dvl:Dvul_1016 acetyl-CoA carboxylase; PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region. (755 aa) |
| | Daes_2079 | KEGG: dsa:Desal_2840 hypothetical protein. (215 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | Daes_1993 | TIGRFAM: N-acetyl sugar amidotransferase; KEGG: lpa:lpa_01155 LPS biosynthesis protein, PseA-like protein. (404 aa) |
| | hisH-2 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (224 aa) |
| | Daes_1991 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (289 aa) |
| | Daes_1990 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: nwi:Nwi_2393 short-chain dehydrogenase/reductase SDR. (267 aa) |
| | Daes_1970 | KEGG: geo:Geob_0664 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (356 aa) |
| | Daes_1954 | PFAM: ferredoxin-dependent glutamate synthase; KEGG: dsa:Desal_3279 ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (544 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | Daes_1883 | PFAM: membrane bound O-acyl transferase MBOAT family protein; KEGG: dat:HRM2_03620 AlgI1; Belongs to the membrane-bound acyltransferase family. (484 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (259 aa) |
| | Daes_1774 | KEGG: dsa:Desal_2397 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | Daes_1744 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa) |
| | Daes_1743 | KEGG: dsa:Desal_1997 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (410 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (124 aa) |
| | Daes_1737 | TIGRFAM: nucleotide sugar dehydrogenase; KEGG: dde:Dde_2042 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation. (445 aa) |
| | Daes_1718 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (345 aa) |
| | Daes_1707 | KEGG: dma:DMR_17130 serine acetyltransferase. (306 aa) |
| | Daes_1706 | KEGG: dma:DMR_17120 cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | Daes_1695 | PFAM: amino acid-binding ACT domain protein; KEGG: app:CAP2UW1_0275 acetolactate synthase 1 regulatory subunit. (92 aa) |
| | Daes_1611 | Radical SAM domain protein; KEGG: clj:CLJU_c36250 putative Fe-S oxidoreductase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (350 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa) |
| | Daes_1551 | KEGG: dsa:Desal_1952 LL-diaminopimelate aminotransferase; TIGRFAM: LL-diaminopimelate aminotransferase; PFAM: aminotransferase class I and II. (388 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | Daes_1528 | PFAM: glutamate synthase alpha subunit domain protein; KEGG: dvm:DvMF_0544 glutamate synthase alpha subunit domain protein. (252 aa) |
| | Daes_1524 | KEGG: dsa:Desal_1630 glutamate synthase (NADPH); PFAM: ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (508 aa) |
| | argD | KEGG: dsa:Desal_1626 acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa) |
| | Daes_1495 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (249 aa) |
| | Daes_1492 | KEGG: dma:DMR_26040 diaminopimelate aminotransferase; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein. (408 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | Daes_1452 | KEGG: dsa:Desal_2327 pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein. (472 aa) |
| | Daes_1451 | PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region; KEGG: dsa:Desal_2328 acetyl-CoA carboxylase. (748 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | Daes_1440 | PFAM: aminotransferase class I and II; KEGG: dsa:Desal_2439 aminotransferase class I and II. (403 aa) |
| | Daes_1439 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; KEGG: dsa:Desal_2440 homoserine dehydrogenase. (432 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | Daes_1312 | KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa) |
| | Daes_1303 | PFAM: aminoglycoside phosphotransferase; KEGG: dat:HRM2_00370 conserved hypothetical protein (putative phosphotransferase). (318 aa) |
| | Daes_1276 | KEGG: gme:Gmet_2664 radical SAM family protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (315 aa) |
| | Daes_1256 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa) |
| | argH | KEGG: dvm:DvMF_0048 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (462 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: dsa:Desal_1785 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (410 aa) |
| | Daes_1252 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (300 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | Daes_1223 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (482 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: dsa:Desal_2171 carbamoyl-phosphate synthase, large subunit; SMART: MGS domain protein; Belongs to the CarB family. (1078 aa) |
| | Daes_1196 | SMART: beta-lactamase domain protein; KEGG: rfr:Rfer_1985 beta-lactamase-like. (293 aa) |
| | Daes_1143 | PFAM: Radical SAM domain protein; KEGG: cce:Ccel_2352 radical SAM domain protein. (325 aa) |
| | Daes_1136 | Glutamate--putrescine ligase; KEGG: rpa:RPA1401 putative glutamine synthetase III; PFAM: glutamine synthetase catalytic region. (458 aa) |
| | Daes_1020 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (377 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (125 aa) |
| | Daes_0964 | PFAM: Methyltransferase type 11; KEGG: dsa:Desal_1449 methyltransferase type 11. (256 aa) |
| | Daes_0961 | PFAM: aminotransferase class-III; KEGG: dap:Dacet_1109 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (198 aa) |
| | Daes_0955 | PFAM: 3-dehydroquinate synthase; KEGG: dsa:Desal_3064 3-dehydroquinate synthase. (327 aa) |
| | Daes_0954 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase, type II; KEGG: dvl:Dvul_2475 chorismate mutase; SMART: Chorismate mutase. (367 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (452 aa) |
| | Daes_0952 | PFAM: Prephenate dehydrogenase; KEGG: dsa:Desal_3061 prephenate dehydrogenase. (256 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | Daes_0948 | KEGG: dma:DMR_05280 indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: dba:Dbac_2816 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (208 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | Daes_0896 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: dba:Dbac_2124 alcohol dehydrogenase zinc-binding domain protein. (338 aa) |
| | Daes_0846 | PFAM: GCN5-related N-acetyltransferase; KEGG: dde:Dde_0188 hypothetical protein. (279 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: dsa:Desal_3776 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | Daes_0817 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (384 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (232 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (341 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | Daes_0716 | Manually curated; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: nde:NIDE2699 asparagine synthase; PFAM: asparagine synthase; glutamine amidotransferase class-II. (626 aa) |
| | Daes_0715 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: nde:NIDE2699 asparagine synthase; PFAM: asparagine synthase. (630 aa) |
| | Daes_0710 | PFAM: Radical SAM domain protein; KEGG: dfe:Dfer_0205 radical SAM domain protein. (325 aa) |
| | Daes_0700 | PFAM: asparagine synthase; glutamine amidotransferase class-II; manually curated; KEGG: mag:amb0119 asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (631 aa) |
| | Daes_0658 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: dma:DMR_33050 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase. (404 aa) |
| | Daes_0649 | SMART: beta-lactamase domain protein; KEGG: mem:Memar_2194 beta-lactamase domain-containing protein. (278 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa) |
| | Daes_0593 | KEGG: dsa:Desal_1338 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (332 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | Daes_0408 | KEGG: fpl:Ferp_0339 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (271 aa) |
| | Daes_0407 | Hypothetical protein; KEGG: cbh:CLC_2591 radical SAM domain-containing protein. (289 aa) |
| | Daes_0296 | KEGG: dsa:Desal_1338 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (332 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (296 aa) |
| | Daes_0102 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: neu:NE1688 D-isomer specific 2-hydroxyacid dehydrogenase. (308 aa) |
| | Daes_0090 | KEGG: ava:Ava_1119 glycosyl transferase family protein; PFAM: glycosyl transferase family 2; SMART: Tetratricopeptide repeat. (733 aa) |
| | Daes_0042 | KEGG: dsa:Desal_1479 acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (159 aa) |
